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Diabetes Care:强化血糖控制可降低手术部位感染发生率

2014-04-09 佚名 丁香园

降低外科重症监护病房(ICU)患者手术部位感染(SSI)的最佳围手术期血糖范围仍不清楚。为此,来自日本高知大学医学院的Okabayashi教授及其团队进行了一项研究,试图明确围手术期强化胰岛素治疗(IT)是否可以减少患者手术部位感染发生率。该研究结果在线发表在2014年03月21日的Diabetes Care杂志上。 该研究中,447例外科重症监护病房患者被随机分到接受强化胰岛素治疗(血糖目标范

降低外科重症监护病房(ICU)患者手术部位感染(SSI)的最佳围手术期血糖范围仍不清楚。为此,来自日本高知大学医学院的Okabayashi教授及其团队进行了一项研究,试图明确围手术期强化胰岛素治疗(IT)是否可以减少患者手术部位感染发生率。该研究结果在线发表在2014年03月21日的Diabetes Care杂志上。

该研究中,447例外科重症监护病房患者被随机分到接受强化胰岛素治疗(血糖目标范围为4.4-6.1mmol/l)或普通胰岛素治疗(血糖目标范围为7.7-10.0mmol/l)。研究主要终点为手术部位感染发生率。

研究结果中,分别有225例患者和222例患者被分到普通胰岛素治疗组和强化胰岛素治疗组。在外科重症监护病房治疗期间,两个治疗组中没有患者发生低血糖症(<4。4mmol/l)。整个研究期间,肝胆胰术后手术部位感染的发生率为6.7%。与普通胰岛素治疗组相比,强化胰岛素治疗组患者术后手术部位感染发生率较低,而且,胰腺切除术后胰漏发生率也较低。与普通胰岛素治疗组相比,强化胰岛素治疗组患者所需的住院时间明显缩短。

该研究提示,强化胰岛素治疗可降低肝胆胰手术患者术后手术部位感染发生率,而且,与血糖目标范围7.7-10.0mmol/l患者相比,血糖目标范围4.4-6.1mmol/l患者有较低的手术部位感染发生率。

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    2014-05-09 智智灵药
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