Arthritis & Rheumatol：类风湿关节炎患者胰岛素抵抗增加

2014-12-29 佚名生物谷

类风湿关节炎（RA）患者具有胰岛素抵抗（IR）升高现象，但这类患者胰岛素抵抗升高是不与动脉粥样硬化风险增加相关联，相关研究刊登在Arthritis & Rheumatology杂志上。哥伦比亚大学Jon T. Giles，MD和同事比较95例RA患者和统计学匹配的98名非RA对照组之间IR情况，使用HOMA胰岛素抵抗(HOMA-IR)指数评价胰岛素抵抗程度，HOMA-IR即稳态模型胰

类风湿关节炎（RA）患者具有胰岛素抵抗（IR）升高现象，但这类患者胰岛素抵抗升高是不与动脉粥样硬化风险增加相关联，相关研究刊登在Arthritis & Rheumatology杂志上。

哥伦比亚大学Jon T. Giles，MD和同事比较95例RA患者和统计学匹配的98名非RA对照组之间IR情况，使用HOMA胰岛素抵抗(HOMA-IR)指数评价胰岛素抵抗程度，HOMA-IR即稳态模型胰岛素抵抗指数。

研究人员发现，平均HOMA-IR水平在RA组中高出31％，在对照组中，HOMA-IR和与C-反应蛋白和白细胞介素-6水平有关，但这种关联在RA组中较弱。

在那些类风湿性关节炎患者中，HOMA-IR升高与男性和女性的类风湿因子阳性相关，以及与妇女是否使用泼尼松相关。在平均3.2年的随访中，RA患者之间，基线和平均HOMA-IR都不与动脉粥样硬化风险增加相关。虽然RA的IR高于非RA，但更高水平的IR可能不会单独增加动脉粥样硬化风险。

原始出处

Jon T Giles, et al. Insulin resistance in rheumatoid arthritis: Disease related indicators and associations with the presence and progression of subclinical atherosclerosis.Arthritis & Rheumatol.2014

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2015-09-06 shenxlcyp

#类风湿关节炎患者#

73 0
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2015-05-18 baoya

#胰岛#

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2015-10-21 ms6390871039024434

#Arthritis#

57 0
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2014-12-31 lmm397

#关节炎#

64 0
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2014-12-31 ms4964546379600229

#类风湿#

63 0
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2014-12-31 智智灵药

#ART#

54 0
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2014-12-31 xuruicheng

#风湿关节炎#

53 0

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