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JAMA子刊:儿童期开始吸烟(电子烟、香烟和其他烟草产品)与神经认知功能降低相关

2022-08-11 liangying MedSci原创

易受电子烟和烟草产品影响的青少年应被视为烟草预防的重点人群。

在过去十年中,烟草的使用情况发生了重大变化,越来越多的青少年使用电子烟和其他非酒精烟草产品。电子香烟是由电池供电的设备,使用者可以通过加热元件吸入气溶胶。自2014年以来,电子烟的使用已经超过了香烟的使用,成为美国年轻人使用的最流行的烟草产品。其他替代烟草产品,包括雪茄、水烟和无烟烟草产品,也在美国青少年中受到欢迎。

然而,关于早期吸烟与认知表现之间的联系的信息是有限的,特别是对于新兴烟草产品,如电子烟(电子烟)。本研究的目的是评估早期开始吸烟与认知表现之间的相关性。

这项观察性队列研究使用多元线性混合模型研究了开始吸烟与神经认知的纵向关联。来自21个美国网站的9至10岁儿童被纳入第1批次(2016年10月1日至2018年10月31日[n = 11729])并进行了2年的随访(2018年8月1日至2021年1月31日[n] = 10081])。主要结局是神经认知和大脑结构的形态测量以及从结构磁共振成像分析皮层的兴趣区域。

在第1批的11729名参与者中,116名儿童报告曾使用过烟草制品。控制混杂因素后,在第1批的2年随访中,烟草使用者和非使用者在图片词汇测试中表现出较低的分数,吸烟者的结晶认知综合得分低于非吸烟者,且大脑皮层区域和体积的整体测量值显著低于非吸烟者。

烟草使用者与非使用者sMRI形态测量值比较

总之,这项队列研究表明,儿童晚期开始吸烟与较差的认知能力和大脑结构减少有关,并在2年随访中产生持续影响。易受电子烟和烟草产品影响的青少年应被视为烟草预防的重点人群。

参考文献:Dai HD, Doucet GE, Wang Y, et al. Longitudinal Assessments of Neurocognitive Performance and Brain Structure Associated With Initiation of Tobacco Use in Children, 2016 to 2021. JAMA Netw Open. 2022;5(8):e2225991. doi:10.1001/jamanetworkopen.2022.25991

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    2022-08-13 mnda
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    2022-08-11 肿瘤克星

    JAMA上文章都是顶级的,谢谢梅斯及时上新

    0

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