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JAHA:血红蛋白浓度与心血管和全因死亡率的关系!

2018-01-30 xing.T MedSci原创

由此可见,低水平或高水平血红蛋白浓度与心血管和全因死亡率升高有关。将血红蛋白浓度维持在正常范围内与全因死亡率降低相关。

贫血被认为会增加死亡率风险,但高血红蛋白浓度对生存率的影响尚不清楚。血红蛋白浓度变化对普通人群生存率的影响也是未知的。近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,该研究旨在探讨血红蛋白浓度及其变化对心血管和全因死亡风险的影响。

研究人员回顾性地分析了来自NHIS-HEALS(国家健康保险服务-国家健康筛查队列)数据库的一个队列,其中包括170078名男性和122116名没有心血管疾病的女性,基线年龄>40岁,第一次和第二次健康检查时血红蛋白浓度可用。研究人员评估了2个独立变量:“一次性”血红蛋白浓度和血红蛋白从第一次到第二次检查的变化值。

参与者中位随访时间为8年,以确定与心肌梗塞、卒中、所有心血管疾病和所有原因有关的死亡率。校正心血管危险因素后,血红蛋白浓度与心血管和全因死亡率呈U或J形关系。当贫血男性达到正常血红蛋白浓度时,与那些持续贫血的患者相比,全因死亡风险下降,调整后的风险比为0.67(95%可信区间为0.59-0.77)。血红蛋白浓度在正常范围之外的升高和降低均使全因死亡率风险升高(校正后的风险比分别为1.39[95%可信区间为1.28-1.49]和1.10[95%可信区间,1.01-1.20]),相比于持续正常的血红蛋白浓度。女性的趋势相似,但不太显著。

由此可见,低水平或高水平血红蛋白浓度与心血管和全因死亡率升高有关。将血红蛋白浓度维持在正常范围内与全因死亡率降低相关。

原始出处:

Gyeongsil Lee, et al. Association of Hemoglobin Concentration and Its Change With Cardiovascular and All‐Cause Mortality.JAHA.2018. https://doi.org/10.1161/JAHA.117.007723

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    2018-01-31 zhaohui6731
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    2018-01-31 虈亣靌

    谢谢分享学习了

    0

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    2018-01-30 sunfeifeiyang

    0

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