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JGH:梅奥评分和总胆固醇水平可以作为急性中重度溃疡性结肠炎患者诱导治疗期间粘膜愈合的预测因子

2019-06-28 不详 MedSci原创

粘膜愈合是溃疡性结肠炎治疗的最终目的,本项研究旨在确定在开始诱导治疗的3个月和12个月时预测溃疡性结肠炎粘膜愈合的标记物。

背景和目的
粘膜愈合是溃疡性结肠炎治疗的最终目的,本项研究旨在确定在开始诱导治疗的3个月和12个月时预测溃疡性结肠炎粘膜愈合的标记物。

方法
本项单中心前瞻性观察研究纳入了61例因疾病恶化而住院的溃疡性结肠炎成年患者,收集了部分Mayo评分,溃疡性结肠炎内镜下严重程度指数,粪便标记物和开始诱导的实验室数据(0天,2周,3个月和12个月)。

结果
在2周时,3个月时粘膜愈合的患者具有较低的局部Mayo和溃疡性结肠炎内镜指数,并且比没有粘膜愈合的患者具有更高的白细胞计数和总胆固醇。在3个月时,12个月时粘膜愈合的患者的部分Mayo和溃疡性结肠炎内镜指数的严重程度评分低于没有粘膜愈合的患者。

结论
在急性溃疡性结肠炎患者的诱导治疗期间,部分梅奥评分和总胆固醇水平可作为短期治疗靶点。3个月的粘膜愈合与较长时间的粘膜愈合相关。

原始出处:

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    2020-05-14 nymo
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    2020-02-09 guoyibin
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