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J Viral Hepat:瞬时弹性成像中弹性成像质量评价得分:与慢性丙型肝炎肝活检的数字形态学分析相比较

2017-11-26 MedSci MedSci原创

VCTE的性能受个体测量质量评价的影响,考虑到这些标准,在临床实践中可能会提高准确性。

研究背景:瞬时弹性成像(VCTE)被广泛地用于HCV患者无创肝纤维化分期检测;然而,内部验证仅仅基于变化和成功率,缺乏可再生的质量指标。

研究方法:研究分析了剪切波传播的图示,与肝脏组织活检的图像测量结果进行了比较,以消除观察者观察偏差。根据两个形态学标准,个体弹性图像被分层:波的延伸和剪切波传播。然后,基于这些标准分数,在I至III类中分层次(最高到最低的技术质量)。每种检测方法的肝硬度检测结果都与肝组织活检的胶原含量进行比较。

研究结果:3243例弹性成像图纳入研究分析(316例患者)。通过形态学检测肝组织活检,发现66%的样本有显著性肝纤维化,31%的样本有进展性肝纤维化。弹力图质量分析结果:1438例I类检测(44%),1070例II类检测(34%)和735例III类检测。根据class (I, II, III)的严重肝纤维化的受试工作曲线下面积分别是0.941, 0.887和0.766。进展期肝纤维化受试工作曲线下面积分别是0.977, 0.883和0.781。斯皮尔曼相关检测表明,所有分类和纤维化分期是独立相关的(r2=-0.95, p<0.01)。此研究是第一个提出可测量的VTCE质量标准的研究,并通过数字形态学分析来验证它们对肝脏活检的客观评估。

研究结论:VCTE的性能受个体测量质量评价的影响,考虑到这些标准,在临床实践中可能会提高准确性。

原始出处

Mendes LC, Ferreira PA, Miotto N, et al. Transient Elastography: Diagnostic performance compared to digital morphometric analysis of liver biopsy in chronic hepatitis C. J Viral Hepat, 2017, Nov 1. doi: 10.1111/jvh.12822.

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  5. [GetPortalCommentsPageByObjectIdResponse(id=1647899, encodeId=12c6164e89976, content=<a href='/topic/show?id=ac125345160' target=_blank style='color:#2F92EE;'>#慢性丙型肝炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53451, encryptionId=ac125345160, topicName=慢性丙型肝炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d24523536533, createdName=zjubiostat, createdTime=Sat Jul 28 15:36:00 CST 2018, time=2018-07-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1645961, encodeId=7ebc1645961b3, content=<a href='/topic/show?id=663550088ef' target=_blank style='color:#2F92EE;'>#弹性成像#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50088, encryptionId=663550088ef, topicName=弹性成像)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0eb23278887, createdName=tamgche, createdTime=Wed May 09 05:36:00 CST 2018, time=2018-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2005262, encodeId=4cba2005262d9, content=<a href='/topic/show?id=9fcfe3118bb' target=_blank style='color:#2F92EE;'>#瞬时弹性成像#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73118, encryptionId=9fcfe3118bb, topicName=瞬时弹性成像)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e572480, createdName=旅苦化文_208, createdTime=Fri Feb 02 11:36:00 CST 2018, time=2018-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1274609, encodeId=7f8712e4609b6, content=<a href='/topic/show?id=30872089e03' target=_blank style='color:#2F92EE;'>#丙型肝炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20897, encryptionId=30872089e03, topicName=丙型肝炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f503121, createdName=zjubiostat, createdTime=Tue Nov 28 11:36:00 CST 2017, time=2017-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1278053, encodeId=958b12e805316, content=<a href='/topic/show?id=d34e6523544' target=_blank style='color:#2F92EE;'>#活检#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65235, encryptionId=d34e6523544, topicName=活检)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c39f145, createdName=smlt2008, createdTime=Tue Nov 28 11:36:00 CST 2017, time=2017-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1426908, encodeId=089d142690815, content=<a href='/topic/show?id=221d685172' target=_blank style='color:#2F92EE;'>#EPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6851, encryptionId=221d685172, topicName=EPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4a9b4077760, createdName=gwc384, createdTime=Tue Nov 28 11:36:00 CST 2017, time=2017-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1444298, encodeId=f7ae144429863, content=<a href='/topic/show?id=3d9291459d1' target=_blank style='color:#2F92EE;'>#评价#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91459, encryptionId=3d9291459d1, topicName=评价)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1fee5134542, createdName=huagfeg, createdTime=Tue Nov 28 11:36:00 CST 2017, time=2017-11-28, status=1, ipAttribution=)]
    2017-11-28 smlt2008
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    2017-11-28 gwc384
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    2017-11-28 huagfeg
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