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J Clin Virol:低出生体重和头围是感音神经性耳聋的潜在生物标记

2020-06-25 AlexYang MedSci原创

先天性巨细胞病毒感染(cCMV)是最常见的先天性病毒感染,且是儿童感音神经性听力损失(SNHL)的非遗传病因。有症状cCMV感染疾病新生儿具有长期神经后遗症高风险。然而,大多数cCMV感染是无症状的,

先天性巨细胞病毒感染(cCMV)是最常见的先天性病毒感染,且是儿童感音神经性听力损失(SNHL)的非遗传病因。有症状cCMV感染疾病新生儿具有长期神经后遗症高风险。然而,大多数cCMV感染是无症状的,且预后较好。大约10%的会有后遗症,主要是SNHL。

最近,有研究人员评估了无症状先天CMV感染儿童中,发展为感音神经性听力损失的相关风险因素。研究包括了70名无症状cCMV患者,并将孕产妇年龄、孕产妇感染的类型和孕期、孕产妇或新生儿的治疗以及孕龄和新生儿的人体测量作为SNHL的预测因素进行了研究。研究发现,无症状先天CMV感染儿童的SNHL发生率与低出生体重、调整孕龄后的出生体重和头围低z得分有关。逻辑回归分析确认了上述结果。母亲感染的类型和妊娠期与SNHL的发生没有关联。

最后,研究人员指出,他们的研究结果强调了对鉴定无症状cCMV婴儿SNHL发展风险生物标记的需求。调整了孕龄后的出生体重和头围的z得分需要在更大的群体中进一步调查。

原始出处:

Dimitra Dimopoulou , Georgia Kourlaba , Anastasia Antoniadou et al. Low Birth Weight and Head Circumference as Potential Biomarkers of Sensorineural Hearing Loss in Asymptomatic Congenitally CMV-infected Infants. J Clin Virol. 29 May 2020.

 

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    2020-06-25 mswert122

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