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Sci Rep:系统性红斑狼疮的胃肠道受累

2020-04-18 xiangting MedSci原创

基于CT的评分系统有助于更准确地评估和个性化治疗GI受累的SLE患者。

系统性红斑狼疮(SLE)胃肠道(GI)并发症的特征是多节段和多器官受累。这项研究目的是建立一种基于计算机断层扫描(CT)图像的系统来进行疾病评估。

研究回顾性纳入来自两个独立队列的伴GI受累SLE患者。基线时每名患者均接受静脉和口服造影剂的腹部CT扫描。建立并验证CT评分系统,该评分系统包括GI受累的程度、肠壁厚度以及GI外器官受累。结局指标是GI功能恢复的时间,定义为到摄入量≥50%理想卡路里(PO50)可耐受的时间。

分别有54名和37名伴GI受累的SLE患者被纳入推导和验证队列。SLE GI受累的CT评分与患者达到PO50的时间呈正相关(r=0.57,p<0.0001,推导队列;r=0.42,p=0.0093,验证队列)。汇总队列中CT评分≤3的患者达到PO50的时间较短(中位时间为0天),而CT评分>3的患者达到PO50的中位时间明显延长至13天(p<0.0001)。

基于CT的评分系统有助于更准确地评估和个性化治疗GI受累的SLE患者。

原始出处:

Zhiwei Chen. Systemic lupus erythematosus gastrointestinal involvement: a computed tomography-based assessment. Sci Rep. 14 April 2020.

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    2020-04-20 zhouqu_8

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