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J CLIN ENDOCR METAB :适当治疗睡眠呼吸暂停综合征或可降低心脏病和糖尿病风险

2017-07-27 坚尚 中华医学信息导报

美国一项研究表明,适当治疗阻塞性睡眠呼吸暂停综合征(OSA)可能降低心脏病和糖尿病风险。(J Clin Endocr Metab 2017年6月在线版)

美国一项研究表明,适当治疗阻塞性睡眠呼吸暂停综合征(OSA)可能降低心脏病和糖尿病风险。(J Clin Endocr Metab 2017年6月在线版)

研究人员发现,如果OSA患者夜间不使用持续气道正压通气治疗(CPAP)来帮助保持呼吸道畅通,那么他们的心脏健康和血糖情况可能会发生恶化。

这项新研究招募了31例有CPAP使用史的中重度OSA患者。参试者在实验室休息两晚,其中1晚使用CPAP。患者每晚均进行多导睡眠图检查。研究人员在参试者睡眠时每20分钟抽取一次患者血样。
研究发现,未使用CPAP的夜晚,患者出现OSA复发、血氧含量较低、睡眠质量差、心率加快,且血样检查显示,患者的脂肪酸、血糖和皮质醇水平升高。此外,研究人员还发现,参试者在未使用CPAP时血压和动脉僵硬度水平升高,但不影响胰岛素、甘油三酯、葡萄糖生产、口服葡萄糖耐量、胆固醇或超敏C反应蛋白水平。

作者称,因未使用CPAP导致的OSA复发会增加睡眠期间的血浆游离脂肪酸和葡萄糖水平,这与交感神经和肾上腺皮质活化有关。反复暴露于这些代谢变化,可能会导致糖尿病和心血管疾病的发生。

原始出处:
Swati Chopra,Aman Rathore ,Haris Younas,et al.Obstructive Sleep Apnea Dynamically Increases Nocturnal Plasma Free Fatty Acids, Glucose, and Cortisol during Sleep .J Clin Endocrinol Metab. 08 June 2017 ,jc.2017-00619. DOI: https://doi.org/10.1210/jc.2017-00619

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    2018-06-08 一闲
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    2017-11-07 guojianrong
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