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JUM:青少年乳房肿物?少“动”为妙

2015-04-04 Zhang JL译 MedSci原创

乳腺癌是威胁女性健康的最常见恶性肿瘤之一,多见于中老年人群。我国的高发年龄段与西方国家不同,呈现双峰分布,分别集中在绝经前期和绝经后期,即41~45岁和56~60岁。研究发现,不同年龄层次乳腺癌患者生物学特点及临床病理特征不同,与青年乳腺癌相比,老年乳腺癌的侵袭性较低,发展缓慢,恶性程度低,预后好。青年乳腺癌是指年龄≤35岁的乳腺癌病例,国内文献报道占全部乳腺癌的0.3%~11.2%。近年来青年乳

乳腺癌是威胁女性健康的最常见恶性肿瘤之一,多见于中老年人群。我国的高发年龄段与西方国家不同,呈现双峰分布,分别集中在绝经前期和绝经后期,即41~45岁和56~60岁。研究发现,不同年龄层次乳腺癌患者生物学特点及临床病理特征不同,与青年乳腺癌相比,老年乳腺癌的侵袭性较低,发展缓慢,恶性程度低,预后好。青年乳腺癌是指年龄≤35岁的乳腺癌病例,国内文献报道占全部乳腺癌的0.3%~11.2%。近年来青年乳腺癌发病率增高,乳腺癌有年青化倾向,这可能与年青患者体内雌激素水平高有关。


正是因为青年乳腺癌误诊误治的代价较大,因此如果在一个青春期女孩的乳房中发现肿物,她常常将接受乳房肿物活检检查。然而,乳腺癌在青少年中是罕见的,绝大多数的青少年乳腺肿块是良性肿瘤,而那些肿块通常是与荷尔蒙相关的并且随着时间的流逝而消失。

Loyola大学卫生系统最近的一项发表在Journal of Ultrasound in Medicine杂志上的研究表明,在很多情况下,乳房超声检查可以取代乳房肿物活检的需要。

Loyola的放射科医生以37名少女共45个乳房肿块为研究对象,通过超声波检查对乳房肿物初始大小以及后续增长进行检测,以确定乳房肿块是应该进行保守治疗还是进行更为积极的侵入性组织活检。

该女性群体被分成三组。第一组(n = 9)进行了后续的超声波检查以及活检,第二组(n = 13)只进行活检而第三组(n = 23)则只进行了超声检测随访而没有进行活检。在后续随访的超声检查中,并没有发现一块肿物的外形出现变化,而且所有肿块的活检结果均是良性。

研究人员也对其他因素进行了研究,包括肿块大小、体积以及体积的变化。研究结果指出,如果只对乳房肿块直径大于3厘米以及体积变化每月超过16%的患者进行乳房肿物活检,那么活检数量能够减少第一组中的89%和第三组中的96%。

该研究作者、Loyola大学Chicago Stritch医学院放射学系的教授Aruna Vade博士说:“这些发现表明,如果在后续随访乳房超声检查中,发现良性肿物没有符合总直径最大尺寸大于3厘米和体积变化每月超过16%,那么不需要进行活检。”

在切除活检中,医生通常作一个沿乳房轮廓进行的切口来对肿块进行切除。然而,这个过程有导致疼痛、伤疤和乳房畸形的可能。

Vade和她的同事建议切除活检是用于那些高度怀疑恶性的乳房肿块,这些肿块是利用超声诊断可疑恶性、乳房肿块生长变大或病人肿物以及发现有恶性肿瘤或具有癌症的家族病史。


原始出处:
Jawahar, A. Vade, K. Ward, G. Okur, P. Subbaiah. Biopsy Versus Conservative Management of Sonographically Benign-Appearing Solid Breast Masses in Adolescents. Journal of Ultrasound in Medicine, 2015; 34 (4): 617 DOI: 10.7863/ultra.34.4.617

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    2017-03-19 laymankey

    感谢分享一下!

    0

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    2015-10-27 LSJ120
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    2015-05-24 ljjj1053

    不错,学习了

    0

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    2015-04-11 twostops

    非常好噢!

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=180999, encodeId=fc261809997e, content=感谢分享一下!, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=20971999626, createdName=laymankey, createdTime=Sun Mar 19 00:04:07 CST 2017, time=2017-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1680057, encodeId=7026168005e48, content=<a href='/topic/show?id=67e282e66d8' target=_blank style='color:#2F92EE;'>#肿物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82766, encryptionId=67e282e66d8, topicName=肿物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=179b27837900, createdName=LSJ120, createdTime=Tue Oct 27 12:13:00 CST 2015, time=2015-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=24726, encodeId=054224e262f, content=不错,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=ac181616815, createdName=ljjj1053, createdTime=Sun May 24 12:50:00 CST 2015, time=2015-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=20161, encodeId=dd56201613a, content=非常好噢!, beContent=null, objectType=article, channel=null, level=null, likeNumber=166, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=28c01618629, createdName=twostops, createdTime=Sat Apr 11 11:55:00 CST 2015, time=2015-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19877, encodeId=37b2198e749, content=还是先做无创性的吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=184, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8b26101142, createdName=leaderbilly, createdTime=Tue Apr 07 16:17:00 CST 2015, time=2015-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19608, encodeId=2d88196085b, content=b超的功能还是很强大的!, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=70121620568, createdName=jiasha, createdTime=Mon Apr 06 11:32:00 CST 2015, time=2015-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19525, encodeId=12cb1952577, content=深有同感!, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f0a31620495, createdName=fengcongzhilei, createdTime=Sun Apr 05 14:36:00 CST 2015, time=2015-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19483, encodeId=45901948312, content=你不做…………会被告的, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=hbwang006, createdTime=Sun Apr 05 07:48:00 CST 2015, time=2015-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19453, encodeId=809a1945321, content=这个。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/03/28/a28e8ea268716dfc601012321847bccf.jpg, createdBy=e21a1620364, createdName=清氺訫, createdTime=Sun Apr 05 00:12:00 CST 2015, time=2015-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19454, encodeId=2f3e1945442, content=有点吓人, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/03/28/a28e8ea268716dfc601012321847bccf.jpg, createdBy=e21a1620364, createdName=清氺訫, createdTime=Sun Apr 05 00:12:00 CST 2015, time=2015-04-05, status=1, ipAttribution=)]
    2015-04-07 leaderbilly

    还是先做无创性的吧

    0

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    2015-04-06 jiasha

    b超的功能还是很强大的!

    0

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    2015-04-05 fengcongzhilei

    深有同感!

    0

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    2015-04-05 hbwang006

    你不做…………会被告的

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=180999, encodeId=fc261809997e, content=感谢分享一下!, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=20971999626, createdName=laymankey, createdTime=Sun Mar 19 00:04:07 CST 2017, time=2017-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1680057, encodeId=7026168005e48, content=<a href='/topic/show?id=67e282e66d8' target=_blank style='color:#2F92EE;'>#肿物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82766, encryptionId=67e282e66d8, topicName=肿物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=179b27837900, createdName=LSJ120, createdTime=Tue Oct 27 12:13:00 CST 2015, time=2015-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=24726, encodeId=054224e262f, content=不错,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=ac181616815, createdName=ljjj1053, createdTime=Sun May 24 12:50:00 CST 2015, time=2015-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=20161, encodeId=dd56201613a, content=非常好噢!, beContent=null, objectType=article, channel=null, level=null, likeNumber=166, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=28c01618629, createdName=twostops, createdTime=Sat Apr 11 11:55:00 CST 2015, time=2015-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19877, encodeId=37b2198e749, content=还是先做无创性的吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=184, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8b26101142, createdName=leaderbilly, createdTime=Tue Apr 07 16:17:00 CST 2015, time=2015-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19608, encodeId=2d88196085b, content=b超的功能还是很强大的!, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=70121620568, createdName=jiasha, createdTime=Mon Apr 06 11:32:00 CST 2015, time=2015-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19525, encodeId=12cb1952577, content=深有同感!, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f0a31620495, createdName=fengcongzhilei, createdTime=Sun Apr 05 14:36:00 CST 2015, time=2015-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19483, encodeId=45901948312, content=你不做…………会被告的, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=hbwang006, createdTime=Sun Apr 05 07:48:00 CST 2015, time=2015-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19453, encodeId=809a1945321, content=这个。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/03/28/a28e8ea268716dfc601012321847bccf.jpg, createdBy=e21a1620364, createdName=清氺訫, createdTime=Sun Apr 05 00:12:00 CST 2015, time=2015-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19454, encodeId=2f3e1945442, content=有点吓人, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/03/28/a28e8ea268716dfc601012321847bccf.jpg, createdBy=e21a1620364, createdName=清氺訫, createdTime=Sun Apr 05 00:12:00 CST 2015, time=2015-04-05, status=1, ipAttribution=)]
    2015-04-05 清氺訫

    这个。。。

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=180999, encodeId=fc261809997e, content=感谢分享一下!, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=20971999626, createdName=laymankey, createdTime=Sun Mar 19 00:04:07 CST 2017, time=2017-03-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1680057, encodeId=7026168005e48, content=<a href='/topic/show?id=67e282e66d8' target=_blank style='color:#2F92EE;'>#肿物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82766, encryptionId=67e282e66d8, topicName=肿物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=179b27837900, createdName=LSJ120, createdTime=Tue Oct 27 12:13:00 CST 2015, time=2015-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=24726, encodeId=054224e262f, content=不错,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=ac181616815, createdName=ljjj1053, createdTime=Sun May 24 12:50:00 CST 2015, time=2015-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=20161, encodeId=dd56201613a, content=非常好噢!, beContent=null, objectType=article, channel=null, level=null, likeNumber=166, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=28c01618629, createdName=twostops, createdTime=Sat Apr 11 11:55:00 CST 2015, time=2015-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19877, encodeId=37b2198e749, content=还是先做无创性的吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=184, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8b26101142, createdName=leaderbilly, createdTime=Tue Apr 07 16:17:00 CST 2015, time=2015-04-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19608, encodeId=2d88196085b, content=b超的功能还是很强大的!, beContent=null, objectType=article, channel=null, level=null, likeNumber=135, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=70121620568, createdName=jiasha, createdTime=Mon Apr 06 11:32:00 CST 2015, time=2015-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19525, encodeId=12cb1952577, content=深有同感!, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f0a31620495, createdName=fengcongzhilei, createdTime=Sun Apr 05 14:36:00 CST 2015, time=2015-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19483, encodeId=45901948312, content=你不做…………会被告的, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=hbwang006, createdTime=Sun Apr 05 07:48:00 CST 2015, time=2015-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19453, encodeId=809a1945321, content=这个。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/03/28/a28e8ea268716dfc601012321847bccf.jpg, createdBy=e21a1620364, createdName=清氺訫, createdTime=Sun Apr 05 00:12:00 CST 2015, time=2015-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=19454, encodeId=2f3e1945442, content=有点吓人, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/03/28/a28e8ea268716dfc601012321847bccf.jpg, createdBy=e21a1620364, createdName=清氺訫, createdTime=Sun Apr 05 00:12:00 CST 2015, time=2015-04-05, status=1, ipAttribution=)]
    2015-04-05 清氺訫

    有点吓人

    0

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