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判断主动脉瓣反流严重程度有简单指标!JACC研究:舒张压低和心率快的患者,要引起警惕

2020-01-14 xujing 中国循环杂志

近日,JACC上发表的一项研究提示,对于中重度主动脉瓣反流患者,如果舒张压低于70 mmHg和静息心率高于60次/分,死亡风险均显着增加。研究者建议,对于这类患者,应常规监测心率和舒张压,对于合并高血压的主动脉瓣反流的患者,应避免强化降低舒张压。研究者发现,基础舒张压、静息心率均与患者的死亡风险独立相关,舒张压每增加10 mmHg,死亡风险降低21%,静息心率每增加10次/分,死亡风险增加23%。

近日,JACC上发表的一项研究提示,对于中重度主动脉瓣反流患者,如果舒张压低于70 mmHg和静息心率高于60次/分,死亡风险均显着增加。

研究者建议,对于这类患者,应常规监测心率和舒张压,对于合并高血压的主动脉瓣反流的患者,应避免强化降低舒张压。

研究者发现,基础舒张压、静息心率均与患者的死亡风险独立相关,舒张压每增加10 mmHg,死亡风险降低21%,静息心率每增加10次/分,死亡风险增加23%。

研究发现,主动脉瓣反流患者的死亡风险随着静息心率的增加和舒张压的降低而上升。

研究数据显示,舒张压与死亡率呈非线性的负相关,在舒张压为70 mmHg时死亡率开始上升,在55 mmHg时达到高峰。

而静息心率与死亡率呈线性正相关,心率在60次/分时死亡率开始上升。

此外,研究还发现,主动脉瓣手术后,舒张压不能预测死亡率,而静息心率仍可预测术后的死亡率。

研究连续入选2006-2017年820例中重度主动脉瓣反流患者,平均随访5.5年。400例患者接受了手术治疗,153例患者死亡。药物治疗的1年、5年和10年生存率分别为94%、79%、 63%。

来源:Li-Tan Yang,et al. Diastolic Blood Pressure and Heart Rate Are Independently Associated With Mortality in Chronic Aortic Regurgitation.J Am Coll Cardiol, 2020; 75: 29–39.

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    2021-04-22 Doctoryangbai

    学习了

    0

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    2020-09-04 hbwxf
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    2020-01-16 feifers

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