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NEJM:广东学者:新冠病毒感染早期,病毒载量就很高,无症状和有症状的感染者病毒载量相似!

2020-02-21 xujing 中国循环杂志

近日,广东学者在《新英格兰医学杂志》发表通讯文章称,新冠病毒传播发生在感染早期,无症状者的病毒传播能力与有症状者相似。

近日,广东学者在《新英格兰医学杂志》发表通讯文章称,新冠病毒传播发生在感染早期,无症状者的病毒传播能力与有症状者相似。

研究发现,新冠病毒患者在症状发作后早期就可检测到较高的病毒载量。

研究者分析,这与流感相似,与SARS不同。根据以往研究,SARS感染发病早期呼吸道病毒载量适中,发病后10天左右病毒载量达到高峰。

研究还发现,新冠病毒患者鼻部中的病毒载量高于咽喉部。

研究者监测了中国广东省珠海市18例新冠病毒患者的呼吸道标本中的新冠病毒病毒载量,包括17例症状者和1例有接触史但无症状者。

研究者共分析了72个鼻拭子和72个咽拭子,每位患者获得1-9个连续样本。所有患者均使用聚脂棉签。

共有14名刚从武汉回到珠海发烧并确诊新冠病毒感染。症状发作前14天内,没有人去武汉的华南海鲜批发市场。14例患者中13例有肺炎CT表现。

三例患者E、I和P病情严重,入住重症监护病房,其他患者病情呈轻-中度。

与患者E、I和P的密切接触者中有发生感染者。患者E于1月17日在珠海与其妻子(患者L),母亲(患者D)和朋友(患者Z)接触。患者L、患者D分别于1月20日和1月23日出现症状,在症状发作后不久在其鼻和咽拭子中检测到病毒RNA。Z患者无症状,但在接触后第7、10和11天,鼻拭子和咽拭子呈阳性。

患者 I和患者P于1月11日症状首次出现时在珠海探望了他们的女儿(患者H)。1月17日,患者H发烧,症状发作后第1天在鼻和咽拭子中检测到病毒。


图 有症状的新冠病毒患者的咽拭子、鼻拭子的病毒载量

研究发现,新冠病毒患者在症状发作后不久就检测到较高的病毒载量。

而且,研究还发现,在无症状患者中检测到的病毒载量与有症状患者相似,这表明无症状或症状轻微患者存在较强的传播潜力。

原始出处:Lirong Zou, Feng Ruan, Mingxing Huang, et al. SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients. NEJM,February 19, 2020.

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    2020-02-21 wy8611meng

    在无症状患者中检测到的病毒载量与有症状患者相似,这表明无症状或症状轻微患者存在较强的传播潜力。 这点比较吓人

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1485067, encodeId=de06148506eeb, content=<a href='/topic/show?id=4bbe5902ed2' target=_blank style='color:#2F92EE;'>#无症状#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59027, encryptionId=4bbe5902ed2, topicName=无症状)], attachment=null, authenticateStatus=null, createdAvatar=Bioon/avatar/20180429/70baad2aa5a046c5aa2914d262de7d37.jpg, createdBy=bd077990475, createdName=12498da4m34(暂无昵称), createdTime=Sat Feb 22 17:25:00 CST 2020, time=2020-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1491155, encodeId=c4fa149115592, content=<a href='/topic/show?id=fb94e0991b3' target=_blank style='color:#2F92EE;'>#病毒载量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70991, encryptionId=fb94e0991b3, topicName=病毒载量)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c1e8876950, createdName=grace5703, createdTime=Sat Feb 22 17:25:00 CST 2020, time=2020-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=379472, encodeId=86d43e94729f, content=在无症状患者中检测到的病毒载量与有症状患者相似,这表明无症状或症状轻微患者存在较强的传播潜力。 这点比较吓人, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d71e2631096, createdName=wy8611meng, createdTime=Fri Feb 21 09:26:29 CST 2020, time=2020-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1027234, encodeId=a22e102e234c1, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Fri Feb 21 05:25:00 CST 2020, time=2020-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035144, encodeId=cac210351444d, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Fri Feb 21 05:25:00 CST 2020, time=2020-02-21, status=1, ipAttribution=)]
    2020-02-21 公卫新人

    新冠肺炎,疫情何时才能消失

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1485067, encodeId=de06148506eeb, content=<a href='/topic/show?id=4bbe5902ed2' target=_blank style='color:#2F92EE;'>#无症状#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59027, encryptionId=4bbe5902ed2, topicName=无症状)], attachment=null, authenticateStatus=null, createdAvatar=Bioon/avatar/20180429/70baad2aa5a046c5aa2914d262de7d37.jpg, createdBy=bd077990475, createdName=12498da4m34(暂无昵称), createdTime=Sat Feb 22 17:25:00 CST 2020, time=2020-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1491155, encodeId=c4fa149115592, content=<a href='/topic/show?id=fb94e0991b3' target=_blank style='color:#2F92EE;'>#病毒载量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70991, encryptionId=fb94e0991b3, topicName=病毒载量)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c1e8876950, createdName=grace5703, createdTime=Sat Feb 22 17:25:00 CST 2020, time=2020-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=379472, encodeId=86d43e94729f, content=在无症状患者中检测到的病毒载量与有症状患者相似,这表明无症状或症状轻微患者存在较强的传播潜力。 这点比较吓人, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d71e2631096, createdName=wy8611meng, createdTime=Fri Feb 21 09:26:29 CST 2020, time=2020-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1027234, encodeId=a22e102e234c1, content=新冠肺炎,疫情何时才能消失, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=公卫新人, createdTime=Fri Feb 21 05:25:00 CST 2020, time=2020-02-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1035144, encodeId=cac210351444d, content=顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=旺医, createdTime=Fri Feb 21 05:25:00 CST 2020, time=2020-02-21, status=1, ipAttribution=)]
    2020-02-21 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

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