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Heart:非ST段抬高急性冠脉综合征老年患者常规介入治疗与药物治疗比较!

2017-06-17 xing.T MedSci原创

由此可见,常规介入治疗可减少心肌梗死和重复血运重建的发生,可能降低NSTEACS老年患者死亡率但以大出血为代价。该研究的发现强调需要进行进一步的随机对照试验,以更好地确定对死亡率和出血风险的影响。

无论是在非ST段抬高急性冠脉综合征(NSTEACS)的老年人群中血管重建是否优于药物治疗仍存在争议,从随机试验中获得的证据并不太明确。近日,在心脏病领域权威杂志Heart上发表了一篇荟萃分析文章,研究人员旨在比较NSTEACS的老年患者常规介入治疗与初始药物治疗之间的疗效。

研究人员检索了MEDLINE、EMBASE和Cochrane对照试验登记中心,检索了比较≥75岁的NSTEACS患者接受常规介入治疗和初始药物治疗的研究文献。该研究的终点包括长期死亡率、心肌梗死(MI)、血运重建、再住院、卒中和大出血,并报道了比值比。

该分析共纳入了四个符合标准的随机对照试验和三项观察性研究,共包含20540例患者,随访了6个月至5年。常规介入疗法可降低死亡率(比值比为0.67,95%可信区间为0.61-0.74),MI(比值比为0.56,95%可信区间为0.45-0.70)和卒中(比值比为0.53,95%可信区间为0.30-0.95)。仅限于随机对照试验(RCT)的分析证实心肌梗死(比值比为0.51,95%可信区间为0.40-0.66)、血运重建(比值比为0.27,95%可信区间为0.13-0.56)有所减少,死亡率有降低的趋势(比值比为0.84,95%可信区间为0.66-1.06),但以大出血的风险为代价(比值比为2.19,95%可信区间为1.12-4.28)。在最近的研究中大出血的差异并不很明显。

由此可见,常规介入治疗可减少心肌梗死和重复血运重建的发生,可能降低NSTEACS老年患者死亡率但以大出血为代价。该研究的发现强调需要进行进一步的随机对照试验,以更好地确定对死亡率和出血风险的影响。

原始出处:

Sonali R Gnanenthiran,et al. Revascularisation compared with initial medical therapy for non-ST-elevation acute coronary syndromes in the elderly: a meta-analysis. Heart. 2017. http://dx.doi.org/10.1136/heartjnl-2017-311233

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    2017-11-14 lxg951
  4. 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encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Jun 19 07:02:00 CST 2017, time=2017-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1423028, encodeId=2b6b142302881, content=<a href='/topic/show?id=936c16863b5' target=_blank style='color:#2F92EE;'>#ST段抬高#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16863, encryptionId=936c16863b5, topicName=ST段抬高)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=91d33758978, createdName=gdsun, createdTime=Mon Jun 19 07:02:00 CST 2017, time=2017-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1430853, encodeId=7283143085314, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1624352, encodeId=a4c516243527a, content=<a href='/topic/show?id=f27b16862d9' target=_blank style='color:#2F92EE;'>#ST段#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16862, encryptionId=f27b16862d9, topicName=ST段)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=676820671866, createdName=hyf035, createdTime=Mon Jun 19 07:02:00 CST 2017, time=2017-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1630242, encodeId=82f51630242ff, content=<a href='/topic/show?id=7d2764661f6' target=_blank style='color:#2F92EE;'>#治疗比较#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64661, encryptionId=7d2764661f6, topicName=治疗比较)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cbf021471003, createdName=zhangyxzsh, createdTime=Mon Jun 19 07:02:00 CST 2017, time=2017-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212027, encodeId=91d021202ec6, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Sat Jun 17 20:34:45 CST 2017, time=2017-06-17, status=1, ipAttribution=)]
    2017-06-19 zhaojie88
  5. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1624352, encodeId=a4c516243527a, content=<a href='/topic/show?id=f27b16862d9' target=_blank style='color:#2F92EE;'>#ST段#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16862, encryptionId=f27b16862d9, topicName=ST段)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=676820671866, createdName=hyf035, createdTime=Mon Jun 19 07:02:00 CST 2017, time=2017-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1630242, encodeId=82f51630242ff, content=<a href='/topic/show?id=7d2764661f6' target=_blank style='color:#2F92EE;'>#治疗比较#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64661, encryptionId=7d2764661f6, topicName=治疗比较)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cbf021471003, createdName=zhangyxzsh, createdTime=Mon Jun 19 07:02:00 CST 2017, time=2017-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212027, encodeId=91d021202ec6, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Sat Jun 17 20:34:45 CST 2017, time=2017-06-17, status=1, ipAttribution=)]
    2017-06-19 gdsun
  6. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1624352, encodeId=a4c516243527a, content=<a href='/topic/show?id=f27b16862d9' target=_blank style='color:#2F92EE;'>#ST段#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16862, encryptionId=f27b16862d9, topicName=ST段)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=676820671866, createdName=hyf035, createdTime=Mon Jun 19 07:02:00 CST 2017, time=2017-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1630242, encodeId=82f51630242ff, content=<a href='/topic/show?id=7d2764661f6' target=_blank style='color:#2F92EE;'>#治疗比较#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64661, encryptionId=7d2764661f6, topicName=治疗比较)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cbf021471003, createdName=zhangyxzsh, createdTime=Mon Jun 19 07:02:00 CST 2017, time=2017-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212027, encodeId=91d021202ec6, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Sat Jun 17 20:34:45 CST 2017, time=2017-06-17, status=1, ipAttribution=)]
    2017-06-19 zhouqu_8
  7. 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encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Jun 19 07:02:00 CST 2017, time=2017-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1423028, encodeId=2b6b142302881, content=<a href='/topic/show?id=936c16863b5' target=_blank style='color:#2F92EE;'>#ST段抬高#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16863, encryptionId=936c16863b5, topicName=ST段抬高)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=91d33758978, createdName=gdsun, createdTime=Mon Jun 19 07:02:00 CST 2017, time=2017-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1430853, encodeId=7283143085314, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1624352, encodeId=a4c516243527a, content=<a href='/topic/show?id=f27b16862d9' target=_blank style='color:#2F92EE;'>#ST段#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16862, encryptionId=f27b16862d9, topicName=ST段)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=676820671866, createdName=hyf035, createdTime=Mon Jun 19 07:02:00 CST 2017, time=2017-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1630242, encodeId=82f51630242ff, content=<a href='/topic/show?id=7d2764661f6' target=_blank style='color:#2F92EE;'>#治疗比较#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64661, encryptionId=7d2764661f6, topicName=治疗比较)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cbf021471003, createdName=zhangyxzsh, createdTime=Mon Jun 19 07:02:00 CST 2017, time=2017-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212027, encodeId=91d021202ec6, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Sat Jun 17 20:34:45 CST 2017, time=2017-06-17, status=1, ipAttribution=)]
    2017-06-19 slcumt
  8. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1624352, encodeId=a4c516243527a, content=<a href='/topic/show?id=f27b16862d9' target=_blank style='color:#2F92EE;'>#ST段#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16862, encryptionId=f27b16862d9, topicName=ST段)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=676820671866, createdName=hyf035, createdTime=Mon Jun 19 07:02:00 CST 2017, time=2017-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1630242, encodeId=82f51630242ff, content=<a href='/topic/show?id=7d2764661f6' target=_blank style='color:#2F92EE;'>#治疗比较#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64661, encryptionId=7d2764661f6, topicName=治疗比较)], attachment=null, authenticateStatus=null, 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    2017-06-19 hyf035
  9. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1624352, encodeId=a4c516243527a, content=<a href='/topic/show?id=f27b16862d9' target=_blank style='color:#2F92EE;'>#ST段#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16862, encryptionId=f27b16862d9, topicName=ST段)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=676820671866, createdName=hyf035, createdTime=Mon Jun 19 07:02:00 CST 2017, time=2017-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1630242, encodeId=82f51630242ff, content=<a href='/topic/show?id=7d2764661f6' target=_blank style='color:#2F92EE;'>#治疗比较#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64661, encryptionId=7d2764661f6, topicName=治疗比较)], attachment=null, authenticateStatus=null, 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  10. 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createdAvatar=null, createdBy=cbf021471003, createdName=zhangyxzsh, createdTime=Mon Jun 19 07:02:00 CST 2017, time=2017-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=212027, encodeId=91d021202ec6, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Sat Jun 17 20:34:45 CST 2017, time=2017-06-17, status=1, ipAttribution=)]
    2017-06-17 wxl882001

    学习一下

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