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NATURE:外泌体PD-L1助力免疫抑制

2018-08-11 海北 MedSci原创

抗PD-1抗体在治疗肿瘤方面显示出值得瞩目的前景,包括转移性黑素瘤。但是,患者的反应率很低。因此,我们需要更好地了解PD-L1介导的免疫逃避,以预测患者反应,并提高治疗效果。

肿瘤细胞通过上调程序性死亡配体1(PD-L1)的表面表达来逃避免疫监视,其与T细胞上的程序性死亡-1(PD-1)受体相互作用以引发免疫检查点反应。抗PD-1抗体在治疗肿瘤方面显示出值得瞩目的前景,包括转移性黑素瘤。但是,患者的反应率很低。因此,我们需要更好地了解PD-L1介导的免疫逃避,以预测患者反应,并提高治疗效果。
最近,来自宾夕法尼亚大学的研究人员发现,转移性黑色素瘤释放的细胞外囊泡,主要是外泌体形式,表面携带PD-L1。用干扰素-γ(IFN-γ)刺激增加了这些囊泡上PD-L1的量,这抑制了CD8T细胞的功能并促进肿瘤生长。
在患有转移性黑素瘤的患者中,循环外泌体PD-L1的水平与IFN-γ的水平正相关,并且在抗PD-1疗法的过程中变化。在治疗的早期阶段,循环外泌体PD-L1的增加幅度,作为肿瘤细胞对T细胞再生的适应性反应的指标,可以作为分离临床应答者与非应答者的指标。
因此,该研究揭示了肿瘤细胞系统性抑制免疫系统的机制,并为外源性PD-L1作为抗PD-1治疗预测因子的应用提供了理论依据。

原始出处:

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    2019-06-14 liye789132251
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    2018-08-26 zwjnj2

    好好学习天天学习认真的学习

    0

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    2018-08-12 smartjoy
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    2018-08-11 惠映实验室

    学习了,谢谢分享。

    0

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    2018-08-11 惠映实验室

    学习了,谢谢分享。

    0

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    2018-08-11 zwjnj2

    好好学习天天学习认真的学习

    0

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    2018-08-11 lietome15

    好文,值得点赞!认真学习了,把经验应用于实践,为患者解除病痛。

    0

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    2018-08-11 九九消寒

    优质资源,共同学习

    0

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