前沿专利成分- MitoQ 分子 全球首款线粒体靶向抗氧化剂的科学突破与创新应用

上世纪90年代，英国剑桥大学的线粒体项目负责人Mike Murphy教授与新西兰奥塔哥大学的Robin Smith教授共同研发了一种革新的靶向抗氧化分子，旨在深入细胞内部，解决深层次的健康问题。经过不懈努力，他们成功将这一构想付诸实践，创造出了MitoQ（Mitoquinol Mesylate）这一突破性分子。 

MitoQ能够直接作用于细胞的能量核心——线粒体，标志着全球领先的靶向抗氧化科技的诞生。如今，MitoQ经过全球数百家医学科研机构的验证与探索，其在健康领域的巨大潜力也得到了广泛认可。 

MitoQ（Mitoquinol Mesylate）专利分子的研究与临床试验 

以科学为基础，MitoQ的研究和临床试验展现了其在人体健康各方面的显著益处。MitoQ不仅鼓励和支持科学界的研究，还通过实际行动推动相关领域的探索。 

独立科研：迄今为止，MitoQ已进行23项临床试验，并得到了超过810篇科研论文的支持，研发投入已超过6000万美元。这些独立科研成果为MitoQ的有效性和安全性提供了坚实的科学依据。 

顶尖学府：MitoQ的研究得到了全球顶尖学府和科研机构的认可，包括哈佛大学、剑桥大学、约翰斯·霍普金斯大学医学院以及美国国立卫生研究院抗衰老研究中心等。这些机构对MitoQ分子在细胞健康优化方面进行了深入的研究，验证了其对细胞功能的积极影响。 

持续创新：MitoQ的科研团队不断探索细胞健康的前沿领域，并已获得超过60项全球专利。这些专利进一步推动了MitoQ分子技术的创新，体现了其在细胞健康领域中的持续进步和突破。 

研究成果 

截至目前，MitoQ的科研成果已在超过810篇高影响力的同行评审期刊上发表，并通过23项临床试验验证其效果。这些成果不仅体现了MitoQ在科学研究中的重要地位，也为其在健康管理领域的应用奠定了坚实的基础。 

查看MitoQ相关研究报告 

*适用于科研人群，仅供研究用途

血管功能 （25项）

HIF-1α promotes cellular growth in lymphatic endothelial cells exposed to chronically elevated pulmonary lymph flow. Boehme JT et al. Scientific Reports. 2016DOI: 10.1038/s41598-020-80882-1 Source

Mitoquinone (MitoQ) Inhibits Platelet Activation Steps by Reducing ROS Levels. Méndez D et al. International Journal of Molecular Sciences. 2021DOI: 10.3390/ijms21176192 Source

心脏健康（27项）

Prohibitin-1 Is a Dynamically Regulated Blood Protein With Cardioprotective Effects in Sepsis. Mattox TA et al. Journal of the American Heart Association. 2021DOI: 10.1161/JAHA.120.019877 Source

Ceramide modulates electrophysiological characteristics and oxidative stress of pulmonary vein cardiomyocytes. Huang SY et al. European Journal of Clinical Investigation. 2022DOI: 10.1111/eci.13690 Source

神经健康（46项）

Generation of mitochondrial reactive oxygen species is controlled by ATPase inhibitory factor 1 and regulates cognition. Esparza-Moltó PB et al. PLoS biology. 2021DOI: 10.1371/journal.pbio.3001252 Source

Preeclamptic placentae release factors that damage neurons: implications for foetal programming of disease. Scott H et al. Neuronal Signaling. 2018DOI: 10.1042/NS20180139 Source

肝脏健康（18项）

Oxidative stress-mediated mitochondrial fission promotes hepatic stellate cell activation via stimulating oxidative phosphorylation. Zhou et al. Cell Death & Disease. 2022DOI: 10.1038/s41419-022-05088-x Source

Down regulation of NDUFS1 is involved in the progression of parenteral-nutrition-associated liver disease by increasing Oxidative stress. Wan et al. The Journal of Nutritional Biochemistry. 2023DOI: 10.1016/j.jnutbio.2022.109221 Source

肾脏健康（18项）

Wnt/β‐catenin/RAS signaling mediates age‐related renal fibrosis and is associated with mitochondrial dysfunction. Miao J et al. Aging Cell. 2019DOI: 10.1111/acel.13004 Source

Evaluation of a novel mitochondria‐targeted anti-­oxidant therapy for ischaemia-­reperfusion injury in renal transplantation. Hamed M. 2017Source

代谢健康（17项）

Parkin regulates adiposity by coordinating mitophagy with mitochondrial biogenesis in white adipocytes. Moore TM et al. Nature Communications. 2022DOI: 10.1038/s41467-022-34468-2 Source

Fgr kinase is required for proinflammatory macrophage activation during diet-induced obesity. Acín-Pérez R et al. Nature Metabolism. 2020DOI: 10.1038/s42255-020-00273-8 Source

肌肉骨骼健康与运动表现（11项）

Programmed NP Cell Death Induced by Mitochondrial ROS in a One-Strike Loading Disc Degeneration Organ Culture Model. Li, Bao-Liang et al. Oxidative Medicine and Cellular Longevity. 2021DOI: 10.1155/2021/5608133 Source

507 Late-Breaking: Heat Stress and Mitoq Supplementation Impact Skeletal Muscle Mitochondrial Capacities in Pigs. Wesolowski, Lauren T et al. Journal of Animal Science. 2021DOI: 10.1093/jas/skab235.371 Source

皮肤健康（8项）

Mitochondria-targeted antioxidant MitoQ ameliorates ROS production and improves cell viability in cryopreserved buffalo fibroblasts. Punetha, Meeti et al. Tissue and Cell. 2023DOI: 10.1016/j.tice.2023.102067 Source

Mitochondrial Activity Is Upregulated in Nonlesional Atopic Dermatitis and Amenable to Therapeutic Intervention. Leman, Geraldine et al. Journal of Investigative Dermatology. 2022DOI: 10.1016/j.jid.2022.01.035 Source

免疫功能（26项）

The mitochondrial gene-CMPK2 functions as a rheostat for macrophage homeostasis. Arumugam, Prabhakar et al. Frontiers in Immunology. 2022DOI: 10.3389/fimmu.2022.935710 Source

Tumor Microenvironment following Gemcitabine Treatment Favors Differentiation of Immunosuppressive Ly6Chigh Myeloid Cells. Wu, Caijun et al. The Journal of Immunology. 2020DOI: 10.4049/jimmunol.1900930 Source

遗传健康（7项）

Human microvascular dysfunction and apoptotic injury induced by AL amyloidosis light chain proteins. Migrino RQ et al. American Journal of Physiology-Heart and Circulatory Physiology. 2011DOI: 10.1152/ajpheart.00503.2011 Source

Misfolding of short-chain acyl-CoA dehydrogenase leads to mitochondrial fission and oxidative stress. Schmidt SP et al. Molecular Genetics and Metabolism. 2010DOI: 10.1016/j.ymgme.2010.03.009 Source

眼部健康（5项）

Mitochondrial ROS in Slc4a11 KO Corneal Endothelial Cells Lead to ER Stress. Shyam, Rajalekshmy et al. Frontiers in Cell and Developmental Biology. 2022DOI: 10.3389/fcell.2022.878395 Source

MitoROS due to loss of Slc4a11 in corneal endothelial cells induces ER stress, lysosomal dysfunction and impairs autophagy. Shyam, Rajalekshmy et al. 2020DOI: 10.1101/2020.08.27.250977 Source

呼吸健康（14项）

Regulatory effect of mitoQ on the mtROS-NLRP3 inflammasome pathway in leptin-pretreated BEAS-2 cells. Chong, Lei et al. Experimental and Therapeutic Medicine. 2021.DOI: 10.3892/etm.2021.9897 Source

[Mitochondrial coenzyme Q attenuates lipopolysaccharide-induced mitochondria-dependent apoptosis in type II alveolar epithelial cells via phosphatidylinositol 3-kinase/Akt pathway]. Zhou, Jiaqi et al. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2022.DOI: 10.3760/cma.j.cn121430-20211221-01899 Source

生殖与发育生物学（40项）

Antioxidant mitoquinone suppresses benign prostatic hyperplasia by regulating the AR–NLRP3 pathway. Jin, Bo-Ram et al. Redox Biology. 2023.DOI: 10.1016/j.redox.2023.102816 Source

Hypoxia-induced mitochondrial abnormalities in cells of the placenta. Vangrieken, Philippe et al. PLOS ONE. 2021.DOI: 10.1371/journal.pone.0245155 Source

毒性研究（20项）

Microbe-derived antioxidants attenuate cobalt chloride-induced mitochondrial function, autophagy and BNIP3-dependent mitophagy pathways in BRL3A cells. Luo, Zhen et al. Ecotoxicology and Environmental Safety. 2022.DOI: 10.1016/j.ecoenv.2022.113219 Source

Iron-Dependent Mitochondrial Dysfunction Contributes to the Pathogenesis of Pulmonary Fibrosis. Takahashi, Mai et al. Frontiers in Pharmacology. 2022.DOI: 10.3389/fphar.2021.643980 Source

氧化还原生物学（26项）

Ubiquitination and receptor-mediated mitophagy converge to eliminate oxidation-damaged mitochondria during hypoxia. Sulkshane, Prasad et al. Redox Biology. 2021.DOI: 10.1016/j.redox.2021.102047 Source

Detection of 8-oxoguanine and apurinic/apyrimidinic sites using a fluorophore-labeled probe with cell-penetrating ability. Kang, Dong Min et al. BMC Molecular and Cell Biology. 2019.DOI: 10.1186/s12860-019-0236-x Source

细胞健康（41项）

The role of docosahexaenoic acid in mediating mitochondrial membrane lipid oxidation and apoptosis in colonocytes. Ng, Yeevoon et al. Carcinogenesis. 2005.DOI: 10.1093/carcin/bgi163 Source

Targeting glutamine utilization to block metabolic adaptation of tumor cells under the stress of carboxyamidotriazole-induced nutrients unavailability. Shi, Jing et al. Acta Pharmaceutica Sinica. B. 2022.DOI: 10.1016/j.apsb.2021.07.008 Source

评论、社论与快报（158篇）

Oxidative Stress at the Crossroads of Aging, Stroke and Depression. Shao, Anwen et al. Aging and Disease. 2020.DOI: 10.14336/AD.2020.0225 Source

Mitochondrial Dysfunction in Intervertebral Disc Degeneration: From Pathogenesis to Therapeutic Target. Li, Danni; Tao, Fenghua; Jin, Lin. Oxidative Medicine and Cellular Longevity. 2020.DOI: 10.1155/2020/8880320 Source

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