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Allergy Asthma Clin Immunol:中国北方一个乡村地区过敏性和非过敏性鼻炎流行度分析

2018-12-09 AlexYang MedSci原创

大多数流行病学研究报道过敏性鼻炎(AR)和非过敏性鼻炎(NAR)时只评估了自我报道的流行度,并没有进行客观的测量确定。更多的是,关于中国人口的NAR流行度报道非常少见。因此,最近有研究人员探索了中国人口中AR和NAR的流行度和风险因子,且主要基于临床表现和过敏状态。研究人员进行的是一个基于群体的代表性调查,包括了中国北京的1084名当地居民。研究发现,自我报道的AR流行度为46.8%。基于SPT结

大多数流行病学研究报道过敏性鼻炎(AR)和非过敏性鼻炎(NAR)时只评估了自我报道的流行度,并没有进行客观的测量确定。更多的是,关于中国人口的NAR流行度报道非常少见。因此,最近有研究人员探索了中国人口中AR和NAR的流行度和风险因子,且主要基于临床表现和过敏状态。

研究人员进行的是一个基于群体的代表性调查,包括了中国北京的1084名当地居民。研究发现,自我报道的AR流行度为46.8%。基于SPT结果,确定的AR和NAR标准流行度分别为16.78%和24.60%。鼻痒、打喷嚏、鼻漏和充血严重度得分在AR患者中均鼻NAR患者显著更高(P<0.05)。其中在AR自我报道群组中,3种最常见的过敏原为德国小蠊 (16.6%), 粉尘螨(14.6%)和屋尘螨(13.9%)。AR的家族历史和过敏性皮肤炎与AR显著相关(调整后OR:分别为3.53和2.45)。相似的是,并发症、CRS和过敏性皮肤炎为AR和NAR的显著风险因子。

最后,研究人员指出,标准调查问卷和特异性过敏原测试的组合能够为AR和NAR流行度和相关风险因素的评估提供更加准确的结果。

原始出处:


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    2018-12-19 skhzy
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    2018-12-11 膀胱癌
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    2018-12-10 1dde8844m30(暂无匿称)

    学习了

    0

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Notch信号途径在调控人类免疫功能中具有重要的作用,但是过敏性鼻炎(AR)与Ntoch信号途径之间的关系仍旧不清楚。最近,有研究人员调查了Notch信号途径在AR致病和Foxp-3Treg 细胞调控中的作用。研究包括了100名AR患者和50名健康对照。研究发现,与对照组相比,Notch1和Jagged1在AR患者中的表达显著提高(p<0.05)。Notch1和Jagged1在患有重度AR患

Allergol Immunopathol (Madr):过敏性鼻炎中,B细胞OX40配体与CD4+ T细胞血清总lgE和IL-4水平相关性分析

过敏性鼻炎(AR)是一种经典的Th2调节的疾病,能够引起重要的白介素4、5和13的病理性变化。OX40共刺激分子和它的配体互作参与了Th1/Th2细胞平衡调控的免疫响应。考虑到OX40配体(OX40L)与AR之间相关信息的缺乏,最近,有研究人员调查了OX40配体在B淋巴细胞中的表达。研究包括了20名AR患者和20名健康参与者。研究人员利用电化学发光免疫检测(ECL)技术对总血清lgE水平进行测量,

Eur Arch Otorhinolaryngol: 过敏性鼻炎对鼻粘膜重建的不同影响研究

过敏性鼻炎(AR)已经报道与慢性鼻窦炎(CRS)相关。最近,有研究人员调查了AR对CRS鼻粘膜重建的影响。研究人员将募集的患者分成不同的小组:具有鼻息肉(NP)和过敏性鼻炎(AR)的CRS患者(CRSwNPwAR,n=20)、具有NP,不具有AR的CRS患者(CRSwNPsAR; n?=?20)、不具有NP,具有AR的CRS患者(CRSsNPwAR; n?=?20)、不具有NP和AR的CRS患者(

Int Arch Allergy Immunol:在过敏性鼻炎中,MiR-202-5p能够促进M2极化

最近,有研究人员调查了MiR-202-5p对过敏性鼻炎中巨噬细胞的影响。研究包括了30名过敏性鼻炎的患者和10名健康的对照。研究人员利用鼻腔灌洗来收集鼻组织和来源于粘液的巨噬细胞,并利用流式细胞仪检测和分选了2型巨噬细胞,并且还利用qRT-PCR和蛋白免疫印迹来确定MiR-202-5p和MATN2的表达情况。研究人员还利用荧光素酶和生物素RNA-pulldown试验测试了miR-202-5p与MA

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