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PNAS:细菌产生的吲哚可以延长健康寿命

2017-08-22 海北 MedSci原创

已有的多个研究表明,在不同的生物体中,有保守的遗传途径以及小分子能够延长机体寿命。但是,寿命的延长并不意味着健康寿命的延长。健康寿命指的是动物保持健康,没有发生与年龄相关的疾病的时间。相反,现有的延长寿命的突变往往伴随着健康寿命的减少,以及机体的虚弱。因此,一直以来人们都在好奇,是否存在这样的因素或机制,能够独立于机体寿命,延长健康寿命,减少机体的虚弱。

已有的多个研究表明,在不同的生物体中,有保守的遗传途径以及小分子能够延长机体寿命。但是,寿命的延长并不意味着健康寿命的延长。健康寿命指的是动物保持健康,没有发生与年龄相关的疾病的时间。相反,现有的延长寿命的突变往往伴随着健康寿命的减少,以及机体的虚弱。因此,一直以来人们都在好奇,是否存在这样的因素或机制,能够独立于机体寿命,延长健康寿命,减少机体的虚弱。

来自埃默里大学医学院的研究人员发现,共生微生物群产生的吲哚可以在多种生物中延长健康寿命,包括秀丽隐杆线虫,黑腹果蝇和小鼠,但其对最大寿命的影响可以忽略不计。吲哚对于线虫和果蝇健康寿命的影响取决于芳烃受体(AHR),一种保守的异种小分子检测器。在线虫中,吲哚能够在老年个体中诱导和年轻个体相似的基因表达谱,和正常老化相关的基因表达不同。此外,在老年动物中,吲哚能够诱导和卵子发生相关的基因,延长个体的繁殖力和生殖年限。

因此,这些数据表明,吲哚相关的衍生物,以及共生微生物产生的物质能够通过保守的分子途径促进健康的衰老过程。这些数据帮助我们开发基于微生物产生的吲哚及其衍生物,作为治疗手段,帮助延长人类健康寿命,改善体质。


原始出处:

Robert Sonowal et al.  Indoles from commensal bacteria extend healthspanPNAS, August 21, 2017 DOI: 10.1073/pnas.1706464114


本文系梅斯医学(MedSci)原创编译整理,转载需授权


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    2018-07-09 drwjr
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    2017-08-23 lyh994

    开发基于微生物产生的吲哚及其衍生物.作为治疗手段.帮助延长人类健康寿命.改善体质.

    0

  4. 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level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Wed Aug 23 05:43:38 CST 2017, time=2017-08-23, status=1, ipAttribution=)]
    2017-08-23 执着追梦

    学习.谢谢分享

    0

  5. 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    2017-08-23 明月清辉

    谢谢分享.学习了

    0

  6. 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level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Wed Aug 23 05:43:38 CST 2017, time=2017-08-23, status=1, ipAttribution=)]
    2017-08-23 Y—xianghai

    学习了新知识

    0

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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Wed Aug 23 07:12:13 CST 2017, time=2017-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236230, encodeId=1d05236230a0, content=学习受益匪浅.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Wed Aug 23 07:04:01 CST 2017, time=2017-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236202, encodeId=460c236202d3, content=内容丰富.值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Wed Aug 23 06:47:02 CST 2017, time=2017-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236191, encodeId=15b223619103, content=值得推荐一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBWOEtiahpXHGVdbFId5PLgK775YNA1ria3lM9KsJT6iczgIhov5sobd1Nr0raUBP58GkUDzvfDic9RCg/0, createdBy=0d021989245, createdName=189****1577, createdTime=Wed Aug 23 06:33:20 CST 2017, time=2017-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236178, encodeId=4c882361e818, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Wed Aug 23 05:43:38 CST 2017, time=2017-08-23, status=1, ipAttribution=)]
    2017-08-23 清风拂面

    学习受益匪浅.谢谢分享

    0

  8. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201006/4db877c2887649beb09cb5effd0b38c7/916f66edd48a4e77b20ebc3e14b6e45c.jpg, createdBy=141e1980133, createdName=Y—xianghai, createdTime=Wed Aug 23 07:12:13 CST 2017, time=2017-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236230, encodeId=1d05236230a0, content=学习受益匪浅.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Wed Aug 23 07:04:01 CST 2017, time=2017-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236202, encodeId=460c236202d3, content=内容丰富.值得学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Wed Aug 23 06:47:02 CST 2017, time=2017-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236191, encodeId=15b223619103, content=值得推荐一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBWOEtiahpXHGVdbFId5PLgK775YNA1ria3lM9KsJT6iczgIhov5sobd1Nr0raUBP58GkUDzvfDic9RCg/0, createdBy=0d021989245, createdName=189****1577, createdTime=Wed Aug 23 06:33:20 CST 2017, time=2017-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=236178, encodeId=4c882361e818, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Wed Aug 23 05:43:38 CST 2017, time=2017-08-23, status=1, ipAttribution=)]
    2017-08-23 忠诚向上

    内容丰富.值得学习

    0

  9. 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level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Wed Aug 23 05:43:38 CST 2017, time=2017-08-23, status=1, ipAttribution=)]
    2017-08-23 189****1577

    值得推荐一下

    0

  10. 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    2017-08-23 刘煜

    学习了谢谢分享

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