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JACC:LVEF降低的主动脉瓣狭窄患者预后更差

2018-03-26 MedSci MedSci原创

对于部分严重的主动脉瓣狭窄(AS)患者,其左室射血分数(LVEF)有所降低。本研究的目的旨在评估LVEF降低对严重AS患者预后的影响以及预测其的因素。本研究纳入了938例诊断为严重AS的患者,并对所有患者进行了一系列的心超检查,在随访的10年期间,共获得3684个(平均3个/患者)心超图像。分析结果发现,在最初的诊断中,有196例(21%)患者的LVEF<50% (35.1 ± 9.7%),对于这

对于部分严重的主动脉瓣狭窄(AS)患者,其左室射血分数(LVEF)有所降低。本研究的目的旨在评估LVEF降低对严重AS患者预后的影响以及预测其的因素。

本研究纳入了938例诊断为严重AS的患者,并对所有患者进行了一系列的心超检查,在随访的10年期间,共获得3684个(平均3个/患者)心超图像。分析结果发现,在最初的诊断中,有196例(21%)患者的LVEF<50% (35.1 ± 9.7%),对于这些诊断为AS之前LVEF就已经<50%的患者,其LVEF恶化速度更快,而最初LVEF≥50%的患者随访后的平均LVEF>60%,预测LVEF恶化的关联性最强的因子是诊断AS前3年患者的LVEF<60%(OR:0.86; 95% Cl: 0.83 - 0.89; p < 0.001)。在平均3.3年的随访时间里,与LVEF≥60%的患者相比,LVEF<60%患者的死亡率明显更高((p < 0.001)。

研究结果显示,在严重主动脉瓣狭窄患者中,诊断AS前LVEF就有所下降的患者预后更差,LVEF<60%患者的死亡率要更高。

原始出处:

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    2018-11-08 hbwxf
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