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JACC:LFLG主动脉瓣狭窄患者瓣膜置换术后的预后研究

2018-03-22 MedSci MedSci原创

近日,在国际心血管权威杂志JACC上发表了一篇临床研究,旨在评估低流量低压差主动脉瓣狭窄(LFLG-AS)患者经皮主动脉瓣置换术(TAVR)后的临床预后及左室射血分数(LVEF)的变化。本研究纳入了多中心数据库中287例接受有TAVR治疗的LFLG-AS患者,其中有234例患者在术前接受了多巴酚丁胺负荷超声心动图(DSE)检查,在患者出院时和随访1年后对所有患者进行了经胸超声心动图检查。分析结果发

近日,在国际心血管权威杂志JACC上发表了一篇临床研究,旨在评估低流量低压差主动脉瓣狭窄(LFLG-AS)患者经皮主动脉瓣置换术(TAVR)后的临床预后及左室射血分数(LVEF)的变化。

本研究纳入了多中心数据库中287例接受有TAVR治疗的LFLG-AS患者,其中有234例患者在术前接受了多巴酚丁胺负荷超声心动图(DSE)检查,在患者出院时和随访1年后对所有患者进行了经胸超声心动图检查。分析结果发现,研究对象的平均胸外科医师协会评分为7.7%,平均LVEF和压差分别是30.1 ± 9.7% 和25.4 ± 6.6 mm Hg。术后30天、1年和2年的患者死亡率分别为3.8%, 20.1%和32.3%。经多因素分析后,发现慢性阻塞性肺疾病和低血红蛋白与患者的全因死亡率相关,低血红蛋白值和中到重度术后反流是心衰源性死亡和再住院复合终点事件的预测因子。此外,术后随访1年后,患者的LVEF增高了8.3%(95% Cl:6%-11%)。

研究结果显示,经皮主动脉瓣置换术在低流量低压差主动脉瓣狭窄患者中的围手术期疗效较好,但是在术后2年,有近三分之一的患者出现死亡,慢性阻塞性肺疾病、贫血和反流与差的预后呈相关性。

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    2019-02-06 hbwxf
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    2018-05-03 yxch48
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