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PNAS:双阴性T细胞显着促进缺血性中风后的神经炎症

2019-03-02 海北 MedSci原创

已有的研究显示,CD3 + CD4-CD8-T细胞(双阴性T细胞; DNT)通过调节免疫和炎性体内平衡在外周免疫相关疾病中具有多种功能。

已有的研究显示,CD3 + CD4-CD8-T细胞(双阴性T细胞; DNT)通过调节免疫和炎性体内平衡在外周免疫相关疾病中具有多种功能。然而,至今为止,DNT在中枢神经系统中的功能仍然未知。

最近,研究人员发现,中风患者的脑和外周血以及小鼠模型中DNT的水平以时间依赖性方式显着增加。 渗透性DNT通过调节FasL / PTPN2 / TNF-α信号传导途径增强脑免疫和炎症反应,并加剧缺血性脑损伤。

阻断该途径限制了DNT介导的神经炎症,并改善了中风的结果。

因此,该研究结果确定了DNT在缺血性脑中的关键功能,表明这种独特的细胞群是治疗缺血性中风的有吸引力的靶标。


原始出处:

Meng H et al. Double-negative T cells remarkably promote neuroinflammation after ischemic stroke. PNAS, 2019; doi: 10.1073/pnas.1814394116


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    2019-12-14 drwjr
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    2019-03-03 1ddf0692m34(暂无匿称)

    学习了,涨知识

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1717511, encodeId=4fee1e17511d3, content=<a href='/topic/show?id=1a47e436211' target=_blank style='color:#2F92EE;'>#神经炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74362, encryptionId=1a47e436211, topicName=神经炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=662f32423113, createdName=liye789132262, createdTime=Sun Nov 24 10:51:00 CST 2019, time=2019-11-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1856280, encodeId=aafb1856280a3, content=<a href='/topic/show?id=f32014428fc' target=_blank style='color:#2F92EE;'>#PNAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14428, encryptionId=f32014428fc, topicName=PNAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=08e964, createdName=drwjr, createdTime=Sat Dec 14 04:51:00 CST 2019, time=2019-12-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1893158, encodeId=df9a1893158de, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Fri Mar 29 02:51:00 CST 2019, time=2019-03-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1500603, encodeId=af11150060331, content=<a href='/topic/show?id=a1d3e93536b' target=_blank style='color:#2F92EE;'>#缺血性中风#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79353, encryptionId=a1d3e93536b, topicName=缺血性中风)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c54f9440276, createdName=hywen7329, createdTime=Mon Mar 04 10:51:00 CST 2019, time=2019-03-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=361882, encodeId=49b4361882c6, content=学习了,涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Mar 03 09:07:42 CST 2019, time=2019-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1045841, encodeId=a9261045841d5, content=中风是俗称,应该称为缺血性卒中吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=guging, createdTime=Sat Mar 02 22:51:00 CST 2019, time=2019-03-02, status=1, ipAttribution=)]
    2019-03-02 guging

    中风是俗称,应该称为缺血性卒中吧

    0

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