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J Periodontol:骨碎补提取物在犬Ⅱ类根分叉缺损治疗中的免疫组织病理学评价

2018-11-16 MedSci MedSci原创

在牙周治疗中,根分叉缺损仍然是一个具有挑战性的课题。骨碎补(Dryfaria fortunei,Df)是骨科和创伤学领域中常见的中草药。体外和组织工程研究表明,Df诱导成骨细胞增殖并促进人牙周膜细胞的分化。本研究使用引导组织再生(GTR)和与β-磷酸三钙(β-TCP)同种异体混合的Df颗粒研究犬II类根分叉缺损的处理。

在牙周治疗中,根分叉缺损仍然是一个具有挑战性的课题。骨碎补(Dryfaria fortunei,Df)是骨科和创伤学领域中常见的中草药。体外和组织工程研究表明,Df诱导成骨细胞增殖并促进人牙周膜细胞的分化。本研究使用引导组织再生(GTR)和与β-磷酸三钙(β-TCP)同种异体混合的Df颗粒研究犬II类根分叉缺损的处理。

方法:在4只杂种狗中通过外科手术创建了16个II级临界大小的根分叉缺损:8个缺损用GTR处理,Df颗粒与(β-TCP)异质体混合作为实验组,而其他8个用GTR和同质异形体治疗,作为对照。在第4周和第8周处死狗并处理前磨牙以评估治疗结果,包括:成骨细胞计数(OC),牙骨质层厚度(CLT),骨基质中的胶原蛋白百分比(CBM)和碱性磷酸酶(ALP)免疫反应。

结果:与治疗后4周和8周的对照相比,用Df处理实验组的OC,CLT,CBM和ALP免疫反应性值显着增加(P <0.001)。

骨碎补(Drynaria fortunei)治疗犬模型中的根分叉缺损时会促进再生和骨形成。

原始出处:

Marwa M. Afifi, et al.Immunohistopathologic evaluation of Drynaria?fortuneirhizome extract in the management of Class II furcation defects in a canine model.Journal of Periodontology.2018 November. Doi:10.1002/JPER.17-0655

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    2019-05-06 feather89
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    2018-11-17 huagfeg
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    2018-11-17 jktdtl
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