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JAHA:血栓闭塞性脉管炎的远期预后及影响因素

2018-12-01 MedSci MedSci原创

目前,尚缺乏血栓闭塞性脉管炎的远期预后资料,本研究的目的旨在评估血栓闭塞性脉管炎的远期预后和影响预后的因素。本研究纳入分析了224名血栓闭塞性脉管炎患者,并对血管事件和截肢相关危险因素进行了分析。患者的平均诊断年龄为38.5 (32–46)岁,女性占23.8%,白种人占81.7%。经过平均5.7年时间的随访,有58.9%的患者发生血管疾病,21.4%的患者接受了截肢,1.4%的患者死亡。无血管疾病

目前,尚缺乏血栓闭塞性脉管炎的远期预后资料,本研究的目的旨在评估血栓闭塞性脉管炎的远期预后和影响预后的因素。

本研究纳入分析了224名血栓闭塞性脉管炎患者,并对血管事件和截肢相关危险因素进行了分析。患者的平均诊断年龄为38.5 (32–46)岁,女性占23.8%,白种人占81.7%。经过平均5.7年时间的随访,有58.9%的患者发生血管疾病,21.4%的患者接受了截肢,1.4%的患者死亡。无血管疾病的生存率的独立预测因素有非白种人(HR:2.35 [1.30–4.27] P=0.005)和四肢感染(HR:3.29 [1.02–10.6] P=0.045),与截肢相关的因素为肢体感染(HR:12.1 [3.5–42.1], P<0.001)。另外,戒烟的患者截肢风险较没有戒烟的更低(P=0.001)。

研究结果显示,血栓闭塞性脉管炎有34%的患者会在诊断后的15年内发生截肢事件。

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    2018-12-03 zhaohui6731
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    2018-12-01 天地飞扬

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