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Int J Cardiol:D-二聚体阴性对急性主动脉夹层早期评估的影响!

2018-02-02 xing.T MedSci原创

由此可见,该研究发现高血小板计数和低扩张分数是导致D-二聚体阴性结果的独立因素。即使夹层长度很短,对于一些D-二聚体阴性的病人,急诊手术也是必要的。医生应该认识到血浆D-二聚体阴性结果的患者不能排除致命性AAD的情况。

二聚体具有很高的灵敏度,但对急性主动脉夹层(AAD)诊断的特异性较低。已有报道表明D-二聚体阴性患者的夹层长度较短。然而,D-二聚体阴性患者预后是否良好尚不清楚。近日,心血管领域权威杂志International Journal of Cardiology上发表了一篇研究文章,该研究旨在探讨D-二聚体阴性结果对AAD诊断临床意义。

该研究纳入了在2009年4月和2015年3月之间入住研究者所在医疗机构的126例AAD患者(男性71例,女性55例;平均年龄为69±11岁)。就诊时采用血标本进行D-二聚体测定,并评估患者临床特征和结局。

分别有9例(7.1%)和117例(92.9%)患者D-二聚体表现为阴性和阳性。阴性组扩张评分明显低于阳性组,而血小板计数则高于阳性组。多因素分析表明,血小板计数(比值比为1.31(1.09-1.58),P=0.003)和扩展评分(比值比为0.56(0.33-0.96),P=0.03)是阴性结果显著相关。值得注意的是,阴性组中有44%的患者为A型夹层,33%的患者因心脏压塞而接受紧急手术。

由此可见,该研究发现高血小板计数和低扩张分数是导致D-二聚体阴性结果的独立因素。即使夹层长度很短,对于一些D-二聚体阴性的病人,急诊手术也是必要的。医生应该认识到血浆D-二聚体阴性结果的患者不能排除致命性AAD的情况。

原始出处:

Kenichi Nitta,et al. Impact of a negative D-dimer result on the initial assessment of acute aortic dissection.International Journal of Cardiology.2017. https://doi.org/10.1016/j.ijcard.2018.01.104

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    2018-09-29 hxj0117
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    2018-02-03 大爰

    学习并分享!!

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1781856, encodeId=0f431e81856a8, content=<a href='/topic/show?id=5db8409ed8' target=_blank style='color:#2F92EE;'>#Cardiol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4097, encryptionId=5db8409ed8, topicName=Cardiol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Sat Dec 29 14:35:00 CST 2018, time=2018-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1950357, encodeId=e3a5195035eda, content=<a href='/topic/show?id=bfc624041dc' target=_blank style='color:#2F92EE;'>#二聚体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24041, encryptionId=bfc624041dc, topicName=二聚体)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ac59108, createdName=hxj0117, createdTime=Sat Sep 29 12:35:00 CST 2018, time=2018-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1949255, encodeId=57e01949255c1, content=<a href='/topic/show?id=88e0521825b' target=_blank style='color:#2F92EE;'>#急性主动脉夹层#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52182, encryptionId=88e0521825b, topicName=急性主动脉夹层)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=shuangle, createdTime=Fri Jun 01 20:35:00 CST 2018, time=2018-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1310847, encodeId=395c131084ece, content=<a href='/topic/show?id=b15c5628e9' target=_blank style='color:#2F92EE;'>#D-二聚体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5628, encryptionId=b15c5628e9, topicName=D-二聚体)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e093393, createdName=luwei00, createdTime=Sat Feb 03 22:35:00 CST 2018, time=2018-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415264, encodeId=d9321415264c6, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Sat Feb 03 22:35:00 CST 2018, time=2018-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1519560, encodeId=a5e5151956078, content=<a href='/topic/show?id=b63a3323558' target=_blank style='color:#2F92EE;'>#动脉夹层#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33235, encryptionId=b63a3323558, topicName=动脉夹层)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ae5711287462, createdName=mhzhuang@stu.e, createdTime=Sat Feb 03 22:35:00 CST 2018, time=2018-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=284698, encodeId=910028469854, content=学习并分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sat Feb 03 08:07:05 CST 2018, time=2018-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=284459, encodeId=3a75284459b3, content=学习了., beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b4b12216028, createdName=120e71dcm28暂无昵称, createdTime=Fri Feb 02 11:32:26 CST 2018, time=2018-02-02, status=1, ipAttribution=)]
    2018-02-02 120e71dcm28暂无昵称

    学习了.

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