Sci Rep：转录因子谱分析将Sox9鉴定为角膜上皮干细胞中增殖和分化的调节剂

2018-07-14 cuiguizhong MedSci原创

德国纽伦堡大学眼科学系的Menzel-Severing J近日在Sci Rep发表了一篇重要的文章，该研究通过激光捕获显微切割技术，从人供体眼中分离LEPC，并鉴定其特异性表达的TF基因。

德国纽伦堡大学眼科学系的Menzel-Severing J近日在Sci Rep发表了一篇重要的文章，该研究通过激光捕获显微切割技术，从人供体眼中分离LEPC，并鉴定其特异性表达的TF基因。

研究角膜缘上皮干或祖细胞（LEPCs）的转录调控因子（TF）对使用非眼细胞进行再生角膜具有重要的意义。他们发现SoxE和SoxF基因特异在角膜缘表达，特别是Sox9。Sox9在基底LEPC中定位在细胞质中，在角膜上皮细胞中定位在核内，这表明在LEPC增殖和分化期间，Sox9存在核质转运过程，并得到激活。在扩增和角膜上皮伤口愈合后，活化的LEPC中也观察到Sox9的核定位增加。通过RNAi技术，敲除LEPC中SOX9的表达，导致祖细胞标记物角蛋白15等表达降低，角蛋白3等分化标志物的表达增加。SOX9沉默后显着抑制了LEPCs的增殖能力，降低了糖原合酶激酶3β（GSK-3β）的水平，而GSK-3β是Wnt /β-catenin信号传导的负调节因子。相反，通过用外源GSK-3β抑制剂处理LEPC后Sox9表达显着较低，通过Wnt信号传导的小分子抑制剂处理后Sox9的表达显着增强。

他们的研究结果表明，Sox9和Wnt /β-catenin信号在相互抑制的作用过程中，维持角膜缘微环境中的LEPCs在静息、增殖和分化不同状态之间的平衡。 Sox9-Wnt相互作用的分子机制和Sox9的核质穿梭机制可能对改善LEPCs的再生潜力和非眼细胞重编程产生角膜具有巨大启示意义。

原文出处：

Menzel-Severing， J.， et al.， Transcription factor profiling identifies Sox9 as regulator of proliferation and differentiation in corneal epithelial stem/progenitor cells. Sci Rep， 2018. 8(1)： p. 10268.

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2019-04-01 zhangyxzsh

#角膜上皮#

58 0
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2018-09-13 mjldent

#转录#

73 0
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2018-07-19 12296b8em38暂无昵称

牛掰

102 0
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attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sat Jul 14 23:41:04 CST 2018, time=2018-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=331637, encodeId=717e33163ec4, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Jul 14 23:25:50 CST 2018, time=2018-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=331628, encodeId=49453316286e, content=一起学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/TDiaAWyicHgedzX3wKo3qcxudVJib7AfibfvNeufHRF2jG3Bw8MmZyWjIhtBV1mpJI7Sy9n7RcBKK5t3CuOKuOFxkg/0, createdBy=dd702206933, createdName=wzb521zf, createdTime=Sat Jul 14 23:19:44 CST 2018, time=2018-07-14, status=1, ipAttribution=)]
2018-07-16 snowpeakxu

#角膜#

83 0
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attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sat Jul 14 23:41:04 CST 2018, time=2018-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=331637, encodeId=717e33163ec4, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Jul 14 23:25:50 CST 2018, time=2018-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=331628, encodeId=49453316286e, content=一起学习学习, beContent=null, objectType=article, channel=null, 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2018-07-16 lanyan20020090

#转录因子#

49 0
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attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sat Jul 14 23:41:04 CST 2018, time=2018-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=331637, encodeId=717e33163ec4, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Jul 14 23:25:50 CST 2018, time=2018-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=331628, encodeId=49453316286e, content=一起学习学习, beContent=null, objectType=article, channel=null, 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2018-07-15 飛歌

学习了很有用

0 0
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2018-07-14 天地飞扬

了解一下.谢谢分享!

80 0
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2018-07-14 1ddf0692m34(暂无匿称)

学习了.谢谢分享

74 0
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attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sat Jul 14 23:41:04 CST 2018, time=2018-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=331637, encodeId=717e33163ec4, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat Jul 14 23:25:50 CST 2018, time=2018-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=331628, encodeId=49453316286e, content=一起学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/TDiaAWyicHgedzX3wKo3qcxudVJib7AfibfvNeufHRF2jG3Bw8MmZyWjIhtBV1mpJI7Sy9n7RcBKK5t3CuOKuOFxkg/0, createdBy=dd702206933, createdName=wzb521zf, createdTime=Sat Jul 14 23:19:44 CST 2018, time=2018-07-14, status=1, ipAttribution=)]
2018-07-14 清风拂面

谢谢分享学习

89 0
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2018-07-14 wzb521zf

一起学习学习

37 0