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Diabetes:MondoA是人类胰岛β细胞的主要的葡萄糖应答转录因子。

2018-01-01 MedSci MedSci原创

虽然葡萄糖调节胰岛β细胞分泌胰岛素的机制现已被清楚阐明,但葡萄糖调节这些细胞中基因表达的方式仍需要进行深入研究。在人类胰岛βEndoC-βH1细胞和人类胰岛中,MondoA是主要的葡萄糖反应性转录因子,而其类似物chREBP不是。高血糖时,MondoA进入细胞核,诱导葡萄糖反应性基因ARRDC4和TXNIP的表达,TXNIP编码一种与β细胞功能异常和糖尿病密切相关的蛋白质。重要的是,人类β细胞中增

虽然葡萄糖调节胰岛β细胞分泌胰岛素的机制现已被清楚阐明,但葡萄糖调节这些细胞中基因表达的方式仍需要进行深入研究。

在人类胰岛βEndoC-βH1细胞和人类胰岛中,MondoA是主要的葡萄糖反应性转录因子,而其类似物chREBP不是。高血糖时,MondoA进入细胞核,诱导葡萄糖反应性基因ARRDC4和TXNIP的表达,TXNIP编码一种与β细胞功能异常和糖尿病密切相关的蛋白质。

重要的是,人类β细胞中增强的cAMP信号,利用毛喉素或GLP-1类似物Exendin-4,抑制MondoA入核,并有效地抑制TXNIP和ARRDC4表达。此外,研究人员还证实沉默掉Mondoa表达,可提高EndoC-βH1细胞的葡萄糖摄取。
本研究结果强调了MondoA可作为β细胞的新靶点,用以协调对高血糖水平的转录应答。

原始出处:

Paul Richards,et al.MondoA is an Essential Glucose Responsive Transcription Factor in Human Pancreatic Beta Cells.Diabetes  2017 Dec;  db170595.  https://doi.org/10.2337/db17-0595

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    2018-02-24 baoya
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    2018-08-07 mjldent
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  5. 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  8. 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  9. 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createdBy=b8282062892, createdName=changjiu, createdTime=Mon Jan 01 23:47:07 CST 2018, time=2018-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=274558, encodeId=7f2a2e455885, content=学习了.谢谢., beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Mon Jan 01 20:14:23 CST 2018, time=2018-01-01, status=1, ipAttribution=)]
    2018-01-01 changjiu

    学习一下谢谢

    0

  10. 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createdBy=b8282062892, createdName=changjiu, createdTime=Mon Jan 01 23:47:07 CST 2018, time=2018-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=274558, encodeId=7f2a2e455885, content=学习了.谢谢., beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Mon Jan 01 20:14:23 CST 2018, time=2018-01-01, status=1, ipAttribution=)]
    2018-01-01 惠映实验室

    学习了.谢谢.

    0

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Pain:疼痛和葡萄糖影响早产儿的脑发育!

近期,一项发表在杂志Pain上的研究旨在确定程序性疼痛和葡萄糖暴露是否与早产男女儿的结构性和功能性大脑发育发生改变相关联,同时评估了在18个月校正年龄时的神经发育情况。此项研究共51例极早产新生儿(22例男性;平均[IQR]胎龄27.6 [2.0]周),分别在中位月经周数:29.4,31.9 ,和41.1周时接受三次连续扫描,包括T1加权和休息状态功能磁共振成像(MRI)。分别分割了丘脑、基底节和

Chest:小儿并发肺炎后住院时间延长的预测因子。

小儿社区获得性复杂性肺炎(pcacp)的特点是其临床过程延长,但这根据不同情况可能存在很大的可变性。

Free Radic Biol Med:活性氧竟能提高衰老小鼠模型中骨骼肌细胞的适应性

与SAMR1相比,SAMP8中肌肉的黄嘌呤氧化酶ROS产量较高,高ROS产生与更高的胰岛素敏感性和葡萄糖摄取有关并导致较低的线粒体复合物I活性,高ROS生产导致线粒体呼吸链的内在调节,这种生物能量适应可能有助于保持肌肉代谢的灵活性,这为老年相关疾病的治疗提供重要参考。

Am J Clin Nutr:在十二指肠和回肠输注葡萄糖 食欲反应大不同?

2017年9月,发表在《Am J Clin Nutr》一项研究调查了在十二指肠和回肠注入葡萄糖改变食欲反应、食物摄入和分泌饱腹感相关的胃肠肽的差异。调查结果显示,大量营养素输送到近端和远端小肠会引起不同的结局。

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