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Pain:疼痛和葡萄糖影响早产儿的脑发育!

2017-12-16 MedSci MedSci原创

近期,一项发表在杂志Pain上的研究旨在确定程序性疼痛和葡萄糖暴露是否与早产男女儿的结构性和功能性大脑发育发生改变相关联,同时评估了在18个月校正年龄时的神经发育情况。此项研究共51例极早产新生儿(22例男性;平均[IQR]胎龄27.6 [2.0]周),分别在中位月经周数:29.4,31.9 ,和41.1周时接受三次连续扫描,包括T1加权和休息状态功能磁共振成像(MRI)。分别分割了丘脑、基底节和

近期,一项发表在杂志Pain上的研究旨在确定程序性疼痛和葡萄糖暴露是否与早产男女儿的结构性和功能性大脑发育发生改变相关联,同时评估了在18个月校正年龄时的神经发育情况。

此项研究共51例极早产新生儿(22例男性;平均[IQR]胎龄27.6 [2.0]周),分别在中位月经周数:29.4,31.9 ,和41.1周时接受三次连续扫描,包括T1加权和休息状态功能磁共振成像(MRI)。分别分割了丘脑、基底节和总脑容量。从独立分量图中提取功能性静息状态的MRI数据。NICU管理的侵入性操作的总数视为疼痛。使用贝利婴儿发育量表(第二版)评估18个月矫正年龄的神经发育结局。使用广义估计方程评估疼痛和葡萄糖暴露与大脑结构和功能发展的关联。

此项研究结果显示:更多的侵入性操作与丘脑(p <0.001),基底节(p = 0.028)和总脑容量(p = 0.001)的生长缓慢独立相关,特别是在女性中。在葡萄糖暴露和大脑体积之间也观察到类似的相关性。丘脑和感觉运动皮层之间的功能连接与侵入性程序的数目呈负相关。较大的程序性疼痛以及较高的葡萄糖暴露与较差的神经发育结果有关。

这些发现表明:结构性和功能性的大脑发育很容易受到程序性疼痛的影响。用于镇痛的葡萄糖似乎不能缓解疼痛对脑发育的不利影响。女性脑部早期疼痛发展的脆弱性与其他新生儿疾病不同。疼痛和葡萄糖与神经发育之间的关系表明这些因素具有长期的影响。

原始出处:
Schneider J, Duerden EG, et al. PROCEDURAL PAIN AND ORAL GLUCOSE IN PRETERM NEONATES: BRAIN DEVELOPMENT AND SEX-SPECIFIC EFFECTS. Pain. 2017 Dec 1. doi: 10.1097/j.pain.0000000000001123.

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1950534, encodeId=a616195053486, content=<a href='/topic/show?id=24aa84e7146' target=_blank style='color:#2F92EE;'>#脑发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84771, encryptionId=24aa84e7146, topicName=脑发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8ebc122, createdName=yankaienglish, createdTime=Tue Nov 20 22:11:00 CST 2018, time=2018-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270311, encodeId=435d2e0311dd, content=疼痛和葡萄糖与神经发育之间的关系表明这些因素具有长期的影响., beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/30yrQPYKndeHChDiaiaxia9cGlrfibfht87aw13tZ9Uibdql4ibxeovoZJDoBWhQpwsuO2tL8MHicYAbI5Gsa5ic97eBGA/132, createdBy=0ddc2188194, createdName=董海鹏, createdTime=Mon Dec 18 10:26:06 CST 2017, time=2017-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347247, encodeId=43d4134e247ee, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Mon Dec 18 03:11:00 CST 2017, time=2017-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=269850, encodeId=5bee269850d5, content=涨知识.好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sat Dec 16 12:49:35 CST 2017, time=2017-12-16, status=1, ipAttribution=)]
    2017-12-18 董海鹏

    疼痛和葡萄糖与神经发育之间的关系表明这些因素具有长期的影响.

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1950534, encodeId=a616195053486, content=<a href='/topic/show?id=24aa84e7146' target=_blank style='color:#2F92EE;'>#脑发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84771, encryptionId=24aa84e7146, topicName=脑发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8ebc122, createdName=yankaienglish, createdTime=Tue Nov 20 22:11:00 CST 2018, time=2018-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270311, encodeId=435d2e0311dd, content=疼痛和葡萄糖与神经发育之间的关系表明这些因素具有长期的影响., beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/30yrQPYKndeHChDiaiaxia9cGlrfibfht87aw13tZ9Uibdql4ibxeovoZJDoBWhQpwsuO2tL8MHicYAbI5Gsa5ic97eBGA/132, createdBy=0ddc2188194, createdName=董海鹏, createdTime=Mon Dec 18 10:26:06 CST 2017, time=2017-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347247, encodeId=43d4134e247ee, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Mon Dec 18 03:11:00 CST 2017, time=2017-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=269850, encodeId=5bee269850d5, content=涨知识.好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sat Dec 16 12:49:35 CST 2017, time=2017-12-16, status=1, ipAttribution=)]
    2017-12-18 neurowu
  4. [GetPortalCommentsPageByObjectIdResponse(id=1950534, encodeId=a616195053486, content=<a href='/topic/show?id=24aa84e7146' target=_blank style='color:#2F92EE;'>#脑发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84771, encryptionId=24aa84e7146, topicName=脑发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8ebc122, createdName=yankaienglish, createdTime=Tue Nov 20 22:11:00 CST 2018, time=2018-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=270311, encodeId=435d2e0311dd, content=疼痛和葡萄糖与神经发育之间的关系表明这些因素具有长期的影响., beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/30yrQPYKndeHChDiaiaxia9cGlrfibfht87aw13tZ9Uibdql4ibxeovoZJDoBWhQpwsuO2tL8MHicYAbI5Gsa5ic97eBGA/132, createdBy=0ddc2188194, createdName=董海鹏, createdTime=Mon Dec 18 10:26:06 CST 2017, time=2017-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1347247, encodeId=43d4134e247ee, content=<a href='/topic/show?id=88713e938c1' target=_blank style='color:#2F92EE;'>#发育#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37938, encryptionId=88713e938c1, topicName=发育)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f4c124, createdName=neurowu, createdTime=Mon Dec 18 03:11:00 CST 2017, time=2017-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=269850, encodeId=5bee269850d5, content=涨知识.好文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sat Dec 16 12:49:35 CST 2017, time=2017-12-16, status=1, ipAttribution=)]
    2017-12-16 1ddf0692m34(暂无匿称)

    涨知识.好文章

    0

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