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Trigeminal neuralgia diffusivities using Gaussian process classification and merged group tractography

期刊: PAIN, 2021; 162 (2)

Imaging of trigeminal neuralgia (TN) has demonstrated key diffusion tensor imaging-based diffusivity alterations in the trigeminal nerve; however, ima......

Foxo1 selectively regulates static mechanical pain by interacting with Na(v)1.7

期刊: PAIN, 2021; 162 (2)

Mechanical allodynia is a debilitating condition for millions of patients with chronic pain. Mechanical allodynia can manifest in distinct forms, incl......

Optimized acupuncture treatment (acupuncture and intradermal needling) for cervical spondylosis-related neck pain: a multicenter randomized controlled trial

期刊: PAIN, 2021; 162 (3)

Cervical spondylosis (CS)-related neck pain is difficult to treat because of its degenerative nature. The aim of this 9-center, single-blinded, random......

G protein-coupled receptor GPR151 is involved in trigeminal neuropathic pain through the induction of G beta gamma/extracellular signal-regulated kinase-mediated neuroinflammation in the trigeminal ganglion

期刊: PAIN, 2021; 162 (5)

Trigeminal nerve injury-induced neuropathic pain is a debilitating chronic orofacial pain syndrome but lacks effective treatment. G protein-coupled re......

Metabolomic analysis coupled with extreme phenotype sampling identified that lysophosphatidylcholines are associated with multisite musculoskeletal pain

期刊: PAIN, 2021; 162 (2)

Musculoskeletal pain often occurs simultaneously at multiple anatomical sites. The aim of the study was to identify metabolic biomarkers for multisite......

Calcium imaging in population of dorsal root ganglion neurons unravels novel mechanisms of visceral pain sensitization and referred somatic hypersensitivity

期刊: PAIN, 2021; 162 (4)

Mechanisms of visceral pain sensitization and referred somatic hypersensitivity remain unclear. We conducted calcium imaging in Pirt-GCaMP6s mice to g......

Increase in trigeminal ganglion neurons that respond to both calcitonin gene-related peptide and pituitary adenylate cyclase-activating polypeptide in mouse models of chronic migraine and posttraumatic headache

期刊: PAIN, 2021; 162 (5)

A large body of animal and human studies indicates that blocking peripheral calcitonin gene-related peptide (CGRP) and pituitary adenylate cyclase-act......

Histone deacetylase 3 in hippocampus contributes to memory impairment after chronic constriction injury of sciatic nerve in mice

期刊: PAIN, 2021; 162 (2)

Chronic neuropathic pain is frequently accompanied by memory impairment, yet the underlying mechanisms remain unclear. Here, we showed that mice displ......

Hippocampus shape deformation: a potential diagnostic biomarker for chronic back pain in women

期刊: PAIN, 2021; 162 (5)

Sex differences in the quality and prevalence of chronic pain are manifold, with women generally presenting higher incidence and severity. Uncovering ......

Neuropathic pain generates silent synapses in thalamic projection to anterior cingulate cortex

期刊: PAIN, 2021; 162 (5)

Pain experience can change the central processing of nociceptive inputs, resulting in persistent allodynia and hyperalgesia. However, the underlying c......

Antinociceptive properties of an isoform-selective inhibitor of Na(v)1.7 derived from saxitoxin in mouse models of pain

期刊: PAIN, 2021; 162 (4)

The voltage-gated sodium channel Na(v)1.7 is highly expressed in nociceptive afferents and is critically involved in pain signal transmission. Na(v)1.......

Activation of the Notch signaling pathway in the anterior cingulate cortex is involved in the pathological process of neuropathic pain

期刊: PAIN, 2021; 162 (1)

Plastic changes in the anterior cingulate cortex (ACC) are critical in pain hypersensitivity caused by peripheral nerves injury. The Notch signaling p......

Effect of combined pharmacological, behavioral, and physical interventions for procedural pain on salivary cortisol and neurobehavioral development in preterm infants: a randomized controlled trial

期刊: PAIN, 2021; 162 (1)

Repeated procedural pain may lead to increased secretion of cortisol and future neurobehavioral development disorders in preterm infants. Changes in t......

Nociceptor-localized cGMP-dependent protein kinase I is a critical generator for central sensitization and neuropathic pain

期刊: PAIN, 2021; 162 (1)

Patients with neuropathic pain often experience exaggerated pain and anxiety. Central sensitization has been linked with the maintenance of neuropathi......

Spinal caspase-6 regulates AMPA receptor trafficking and dendritic spine plasticity through netrin-1 in postoperative pain after orthopedic surgery for tibial fracture in mice

期刊: PAIN, 2021; 162 (1)

Chronic postoperative pain hinders functional recovery after bone fracture and orthopedic surgery. Recently reported evidence indicates that caspase-6......

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