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Antinociceptive properties of an isoform-selective inhibitor of Na(v)1.7 derived from saxitoxin in mouse models of pain

Beckley, JT; Pajouhesh, H; Luu, G; Klas, S; Delwig, A; Monteleone, D; Zhou, X; Giuvelis, D; Meng, ID; Yeomans, DC; Hunter, JC; Mulcahy, JV

Mulcahy, JV (corresponding author), SiteOne Therapeut Inc, 280 Utah Ave,Suite 250, San Francisco, CA 94080 USA.

PAIN, 2021; 162 (4): 1250

Abstract

The voltage-gated sodium channel Na(v)1.7 is highly expressed in nociceptive afferents and is critically involved in pain signal transmission. Na(v)1.......

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