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Free Radic Biol Med:活性氧竟能提高衰老小鼠模型中骨骼肌细胞的适应性

2017-10-21 Emma MedSci原创

与SAMR1相比,SAMP8中肌肉的黄嘌呤氧化酶ROS产量较高,高ROS产生与更高的胰岛素敏感性和葡萄糖摄取有关并导致较低的线粒体复合物I活性,高ROS生产导致线粒体呼吸链的内在调节,这种生物能量适应可能有助于保持肌肉代谢的灵活性,这为老年相关疾病的治疗提供重要参考。

研究显示ROS(活性氧)对胰岛素信号具有相反的影响,主要与骨骼肌的线粒体功能障碍有关,有研究分析SAMP8(衰老加速小鼠易发系)骨骼肌中这三种物质之间的关系,显示其特点是比SAMR1(SAM抗性)小鼠具有更高的氧化应激水平。

研究人员在腓肠肌和股四头肌中调查了氧化应激水平、ROS产生、抗氧化系统、线粒体含量和功能、体外和体内胰岛素信号传导的情况。结果显示,与SAMR1相比,SAMP8中肌肉的黄嘌呤氧化酶ROS产量较高,高ROS产生与更高的胰岛素敏感性和葡萄糖摄取有关并导致较低的线粒体复合物I活性,高ROS生产导致线粒体呼吸链的内在调节,这种生物能量适应可能有助于保持肌肉代谢的灵活性,这为老年相关疾病的治疗提供重要参考。

其中,SAMP8中羰基化蛋白中的肌肉含量是SAMR1两倍(p <0.01),黄嘌呤氧化酶的ROS产生量比SAMR1高70%(p <0.05),且在体内和体外测量胰岛素诱导的Akt磷酸化以及体外测量的肌肉葡萄糖摄取均显著较高(p <0.05)。线粒体呼吸分析显示复合物II和IV的底物的解偶联以及更高的呼吸速率,与复合物II和IV较高的最大活性(分别为+ 18%和62%,p <0.05)一致,而相比之下,复合物I的最大活性降低22%(p <0.05)。所有应变差异在6个月的NAC(N-乙酰半胱氨酸)处理后进行校正,显示高ROS产生参与这些差异。

原始出处:
Barquissau V, et al. Reactive oxygen species enhance mitochondrial function, insulin sensitivity and glucose uptake in skeletal muscle of senescence accelerated prone mice SAMP8. Free Radic Biol Med. 2017 Oct 9;113:267-279. doi: 10.1016/j.freeradbiomed.2017.10.012.

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    2018-04-09 jeanqiuqiu
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    2018-03-29 sunylz
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    2017-10-23 徐岩
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Baidu
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Baidu
map