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异基因骨髓间充质干细胞(MSCs)抑制角膜移植的免疫排斥

2020-07-11 Allan MedSci原创

VISICORT IB期临床试验将首次测试骨髓间充质干细胞(MSCs)疗法对高危角膜移植患者的安全性和可行性。

爱尔兰国立大学的爱尔兰细胞制造中心(CCMI)和Sexton Biotechnologies今日宣布,欧盟监管机构批准了静脉注射异基因骨髓间充质干细胞(MSCs)治疗高危角膜移植患者的临床试验(VISICORT试验)。在VISICORT试验中,CCMI将使用含有nLiven PR培养补充剂的培养基制造健康的供体(同种异体)骨髓MSCs。随后将MSCs冷冻保存,然后运至德国柏林的Charité大学医院眼科进行试验。先前角膜移植失败的患者将在完全厚度的角膜移植前7天和1天接受MSCs的静脉输液。

角膜疾病是最常见的失明原因,严重时需要角膜移植来恢复视力,但免疫介导的排斥反应可能会损坏移植的角膜,这是角膜移植失败的主要原因。在过去的10年中,多项研究表明,同种异体MSCs可以抑制角膜移植的免疫排斥。VISICORT IB期临床试验将首次测试骨髓间充质干细胞(MSCs)疗法对高危角膜移植患者的安全性和可行性。

 

原始出处:

https://www.firstwordpharma.com/node/1739617

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    2020-07-14 独孤立克

    干细胞是热点,但是进入临床仍然需要时间和临床疗效验证哦

    0

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GetPortalCommentsPageByObjectIdResponse(id=1589609, encodeId=03921589609ea, content=<a href='/topic/show?id=da41909e3a6' target=_blank style='color:#2F92EE;'>#角膜移植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90973, encryptionId=da41909e3a6, topicName=角膜移植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8f3817754797, createdName=zhangj7114, createdTime=Mon Jul 13 13:28:08 CST 2020, time=2020-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1625936, encodeId=9e8d16259361f, content=<a href='/topic/show?id=7435122e3c3' target=_blank style='color:#2F92EE;'>#MSCs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12273, encryptionId=7435122e3c3, topicName=MSCs)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=18ac20929511, createdName=zhanfl, createdTime=Mon Jul 13 13:28:08 CST 2020, time=2020-07-13, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1815550, encodeId=a1f518155503c, content=<a href='/topic/show?id=ae359e231d4' target=_blank style='color:#2F92EE;'>#间充质干细#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97231, encryptionId=ae359e231d4, topicName=间充质干细)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b632500090, createdName=h.y200607_23674418, createdTime=Fri Oct 30 21:28:08 CST 2020, time=2020-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1705540, encodeId=95d01e05540a9, content=<a href='/topic/show?id=31f9102015b3' target=_blank style='color:#2F92EE;'>#骨髓间充质干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102015, encryptionId=31f9102015b3, topicName=骨髓间充质干细胞)], attachment=null, authenticateStatus=null, 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topicList=[TopicDto(id=12271, encryptionId=099d122e1cd, topicName=MSC)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83epVh4QoCj2A7xBBEjh8q7ia2BsLkylnuQ15ia2MDzvr28XR0CVvBPpFXTlB1mprG7WgBb06gvn4Eia5Q/132, createdBy=55e02571190, createdName=huanbaofeng, createdTime=Mon Jul 13 13:28:08 CST 2020, time=2020-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1576977, encodeId=9ede15e6977b6, content=<a href='/topic/show?id=201f29042ff' target=_blank style='color:#2F92EE;'>#免疫排斥#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=29042, encryptionId=201f29042ff, topicName=免疫排斥)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32b216353032, createdName=ms6829001416292975, createdTime=Mon Jul 13 13:28:08 CST 2020, time=2020-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1589609, encodeId=03921589609ea, content=<a href='/topic/show?id=da41909e3a6' target=_blank style='color:#2F92EE;'>#角膜移植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90973, encryptionId=da41909e3a6, topicName=角膜移植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8f3817754797, createdName=zhangj7114, createdTime=Mon Jul 13 13:28:08 CST 2020, time=2020-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1625936, encodeId=9e8d16259361f, content=<a href='/topic/show?id=7435122e3c3' target=_blank style='color:#2F92EE;'>#MSCs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12273, encryptionId=7435122e3c3, topicName=MSCs)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=18ac20929511, createdName=zhanfl, createdTime=Mon Jul 13 13:28:08 CST 2020, time=2020-07-13, status=1, ipAttribution=)]
    2020-07-13 snowpeakxu
  6. [GetPortalCommentsPageByObjectIdResponse(id=1815550, encodeId=a1f518155503c, content=<a href='/topic/show?id=ae359e231d4' target=_blank style='color:#2F92EE;'>#间充质干细#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97231, encryptionId=ae359e231d4, topicName=间充质干细)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4b632500090, createdName=h.y200607_23674418, createdTime=Fri Oct 30 21:28:08 CST 2020, time=2020-10-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1705540, encodeId=95d01e05540a9, content=<a href='/topic/show?id=31f9102015b3' target=_blank style='color:#2F92EE;'>#骨髓间充质干细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102015, encryptionId=31f9102015b3, topicName=骨髓间充质干细胞)], attachment=null, authenticateStatus=null, 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GetPortalCommentsPageByObjectIdResponse(id=1589609, encodeId=03921589609ea, content=<a href='/topic/show?id=da41909e3a6' target=_blank style='color:#2F92EE;'>#角膜移植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90973, encryptionId=da41909e3a6, topicName=角膜移植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8f3817754797, createdName=zhangj7114, createdTime=Mon Jul 13 13:28:08 CST 2020, time=2020-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1625936, encodeId=9e8d16259361f, content=<a href='/topic/show?id=7435122e3c3' target=_blank style='color:#2F92EE;'>#MSCs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12273, encryptionId=7435122e3c3, topicName=MSCs)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=18ac20929511, createdName=zhanfl, createdTime=Mon Jul 13 13:28:08 CST 2020, time=2020-07-13, status=1, ipAttribution=)]
    2020-07-13 huanbaofeng
  7. 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GetPortalCommentsPageByObjectIdResponse(id=1589609, encodeId=03921589609ea, content=<a href='/topic/show?id=da41909e3a6' target=_blank style='color:#2F92EE;'>#角膜移植#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90973, encryptionId=da41909e3a6, topicName=角膜移植)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8f3817754797, createdName=zhangj7114, createdTime=Mon Jul 13 13:28:08 CST 2020, time=2020-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1625936, encodeId=9e8d16259361f, content=<a href='/topic/show?id=7435122e3c3' target=_blank style='color:#2F92EE;'>#MSCs#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12273, encryptionId=7435122e3c3, topicName=MSCs)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=18ac20929511, createdName=zhanfl, createdTime=Mon Jul 13 13:28:08 CST 2020, time=2020-07-13, status=1, ipAttribution=)]
  8. 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    2020-07-13 zhanfl

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