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J Clin Periodontol:小型猪用双生长因子改善下颌骨嵴鞍型缺损修复的实验研究

2017-08-30 MedSci MedSci原创

为了验证在聚合物载体中,在rhBMP2中添加少量rhVEGF,低剂量的rhBMP2可以实现与单独使用rhBMP2相当的修复效果。

为了验证在聚合物载体中,在rhBMP2中添加少量rhVEGF,低剂量的rhBMP2可以实现与单独使用rhBMP2相当的修复效果。

在18个小型猪的双侧下颌骨中创建缺损。在12只试验动物中,一侧缺损使用装有400μgrhBMP2 /50μgrhVEGF165的0.5g颗粒PDLLA / CaCO 3复合物填充,另一侧用装有800μgrhBMP2的0.5g颗粒PDLLA / CaCO 3复合物填充。 4周和13周后,对新骨形成面积(mm 2)和骨密度(面积%)进行评估。

结果:4周和13周后,装有400μgrhBMP250μgVEGF165复合物的骨缺损新生骨的面积比800μgrhBMP2的多(11.97 vs 7.97mm 2, p = 0.043;72.48 vs 62.2mm 2, p = 0.028)。填充空白载体的缺损在13周后形成较少的骨(42.75mm 2; p = 0.039和0.020)。

结论:聚合物载体的rhBMP2可以改善下颌骨嵴鞍型缺损修复。加入少量rhVEGF可增加骨形成,同时降低rhBMP2的用量。

原始出处

Markus Troltzsch, Alexander Klenke, Petra Santander, et al. Repair of large saddle defects of the mandibular ridge using dual growth factor release-An experimental pilot study in minipigs. Journal of clinical periodontology. 2017 August. doi: 10.1111/jcpe.12739

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    2017-12-08 feather89
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    2017-10-18 xlysu
  3. [GetPortalCommentsPageByObjectIdResponse(id=1726686, encodeId=59bd1e2668647, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Fri Dec 08 01:04:00 CST 2017, time=2017-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1699687, encodeId=8090169968ef3, content=<a href='/topic/show?id=dd152024130' target=_blank style='color:#2F92EE;'>#下颌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20241, encryptionId=dd152024130, topicName=下颌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c4f29973299, createdName=xlysu, createdTime=Wed Oct 18 12:04:00 CST 2017, time=2017-10-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1419626, encodeId=e84414196263e, content=<a href='/topic/show?id=e2dc2025888' target=_blank style='color:#2F92EE;'>#下颌骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20258, encryptionId=e2dc2025888, topicName=下颌骨)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d9f63514434, createdName=珙桐, createdTime=Fri Sep 01 06:04:00 CST 2017, time=2017-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1517969, encodeId=7ca7151e96921, content=<a href='/topic/show?id=aa2269613cd' target=_blank style='color:#2F92EE;'>#生长因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69613, encryptionId=aa2269613cd, topicName=生长因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3df311117154, createdName=12499e01m50暂无昵称, createdTime=Fri Sep 01 06:04:00 CST 2017, time=2017-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1555260, encodeId=e926155526066, content=<a href='/topic/show?id=f367681e434' target=_blank style='color:#2F92EE;'>#猪#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68174, encryptionId=f367681e434, topicName=猪)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9ec214601917, createdName=muzishouyi, createdTime=Fri Sep 01 06:04:00 CST 2017, time=2017-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=238723, encodeId=b7e9238e2321, content=聚合物载体的rhBMP2可以改善下颌骨嵴鞍型缺损修复.加入少量rhVEGF可增加骨形成.同时降低rhBMP2的用量., beContent=null, objectType=article, channel=null, level=null, likeNumber=122, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Wed Aug 30 16:20:24 CST 2017, time=2017-08-30, status=1, ipAttribution=)]
    2017-09-01 珙桐
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    2017-09-01 muzishouyi
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    2017-08-30 有备才能无患

    聚合物载体的rhBMP2可以改善下颌骨嵴鞍型缺损修复.加入少量rhVEGF可增加骨形成.同时降低rhBMP2的用量.

    0

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