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Diabetes Care:餐后血糖升高和更长的糖尿病病程是脑萎缩的危险因素

2016-07-11 zhaoshuang 译 MedSci原创

根据最近的一项研究发现,长期患有2型糖尿病和高餐后2小时血糖水平的日本老年人与无糖尿病或老年期糖尿病的成年人相比有较低的全脑和海马体积。“在调整潜在混杂因素和排除老年痴呆患者后,这些关联仍保持不变。”直树平林(福冈日本九州大学医学科学研究生院环境医学系博士)和他的同事们报道:“因此,糖尿病是海马萎缩的一个可能的危险因素。在糖尿病的受试者中,海马体萎缩可发生在老年痴呆症的发病前。”在 始于1961

根据最近的一项研究发现,长期患有2型糖尿病和较高水平的餐后2小时血糖的日本老年人与无糖尿病或老年期糖尿病的成年人相比有较低的全脑和海马体积。

“在调整潜在混杂因素和排除老年痴呆患者后,这些关联仍保持不变。”直树平林(福冈日本九州大学医学科学研究生院环境医学系博士)和他的同事们报道:“因此,糖尿病是海马萎缩的一个可能的危险因素。在糖尿病的受试者中,海马体萎缩可发生在老年痴呆症的发病前。”

在始于1961年的Hisayama研究中,平林和同事分析了1238名(540名男性)65岁以上老年人的数据。自1985以来,每6至7年,参与者进行了认知功能和日常活动的全面筛选。这组患者在2012年进行了核磁共振脑扫描和全面健康检查。研究人员调整年龄和性别后测量了大脑总体积(TBV)、颅内容积(ICV)和海马体积(HV),检查他们的糖尿病相关指标和TBV /ICV(全脑萎缩的指标)之间的关联,HV/ICV(海马萎缩的指标)和HV/TBV(在全脑水平海马萎缩情况)。

在这项队列中,有 286(23%)受试者患有糖尿病,其中新诊断83例。与非糖尿病患者相比,研究人员发现,调整混杂因素后糖尿病患者TBV/ICV(77.6% vs. 78.2%;P<001),HV/ICV (0.513%比0.529%;P<001)和HV/TBV(0.66% vs. 0.676%;P = 002)均有较低的平均值。餐后2小时血糖水平较高(至少11.1 /L)的受试者与餐后2小时血糖水平低于7.8毫摩尔/升的受试者相比,以上三个参数均下降,同样的发现见于那些糖尿病病程较长,特别是那些有糖尿病至少 17年的患者。

“有趣的是,我们的研究结果表明,糖尿病患者HV/TBV较低,说明海马萎缩不仅仅反映了糖尿病患者全脑萎缩,而且反映了海马体萎缩也受到糖尿病的影响。”研究人员写道。“此外,在我们的研究中,持续时间较长和糖尿病中年发病与较低的HV有关,可能暗示着糖尿病暴露会加重海马萎缩。我们的研究表明糖尿病的管理和控制对减少全脑和海马萎缩及晚年以后患痴呆症的风险十分重要。”

原始出处:


Hirabayashi N, et al. Association Between Diabetes and Hippocampal Atrophy in Elderly Japanese: The Hisayama Study.Diabetes Care. 2016;doi:10.2337/dc15-2800.

Elevated 2-hour postload glucose, longer diabetes duration risk factors for brain atrophy
.Healio.July 8, 2016


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  4. 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style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Sat May 13 14:43:00 CST 2017, time=2017-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401201, encodeId=96f914012016d, content=<a href='/topic/show?id=3405850e3f4' target=_blank style='color:#2F92EE;'>#脑萎缩#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85073, encryptionId=3405850e3f4, topicName=脑萎缩)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/xdmCjlickSzn2cxg75bTZeYl2VYrTV6hibyMlic5XVFkibQbmFB7tK72afyxE4iclBhv7qd91qSk8Q6yicAcmErXRFxQ/132, createdBy=2c5d2304811, createdName=smartjoy, createdTime=Wed Jul 13 01:43:00 CST 2016, time=2016-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1488448, encodeId=09681488448ba, content=<a href='/topic/show?id=019e1011e589' target=_blank style='color:#2F92EE;'>#餐后血糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101175, encryptionId=019e1011e589, topicName=餐后血糖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=76df8418429, createdName=gjsgj, createdTime=Wed Jul 13 01:43:00 CST 2016, time=2016-07-13, status=1, ipAttribution=)]
    2016-10-11 ylzr123

    赞了,认真探究、学习。

    0

  5. 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createdBy=2c5d2304811, createdName=smartjoy, createdTime=Wed Jul 13 01:43:00 CST 2016, time=2016-07-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1488448, encodeId=09681488448ba, content=<a href='/topic/show?id=019e1011e589' target=_blank style='color:#2F92EE;'>#餐后血糖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101175, encryptionId=019e1011e589, topicName=餐后血糖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=76df8418429, createdName=gjsgj, createdTime=Wed Jul 13 01:43:00 CST 2016, time=2016-07-13, status=1, ipAttribution=)]
    2016-09-21 1e10c84am36(暂无匿称)

    文章很好,非常有益

    0

  6. 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  7. 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    2016-09-13 舒心和人

    学习了新知识,感谢分享

    0

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