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Am J Gastroenterol:α-半乳糖苷酶治疗肠易激综合征患者低聚半乳糖敏感

2017-08-16 zhangfan MedSci原创

研究发现,口服α-半乳糖苷酶可显著缓解肠易激综合征患者低聚半乳糖敏感症状

低聚半乳糖(GOS)属于可发酵的碳水化合物(FODMAPs),可导致肠易激综合征(IBS)患者发生胃肠道症状。近日研究人员开展随机双盲研究考察α-半乳糖苷酶对于缓解FODMAPs 饮食肠胃道反应的效果。

研究招募符合罗马III诊断标准的IBS患者,患者随机接受全剂量(300单位)、半剂量(150单位)的α-半乳糖苷酶治疗或安慰剂,随后患者接受3天的低含量低聚半乳糖饮食,3天高含量低聚半乳糖饮食。每日考察患者的GOS敏感性症状,次日进行呼气氢含量分析。

共31名患者完成了研究,GOS高含量饮食可显著增加患者的GOS敏感性。研究发现,全剂量的α-半乳糖苷酶治疗可显著降低GOS高敏感性患者所有症状(症状评分减少24.5 vs 5.5)、减轻患者腹胀感(20.5 vs 6.5),但呼气氢测试组间无显著差异 (P=0.597)。

研究发现,口服α-半乳糖苷酶可显著缓解肠易激综合征患者低聚半乳糖敏感症状。

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    2018-06-22 许安
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    2017-08-18 minzju5058

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