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硫酸镁的8种临床用法

2015-12-02 佚名 医学之声

①镇惊厥  10%硫酸镁10毫升深部肌肉注射或用 5%葡萄糖稀释成2%~2.5%的溶液缓慢滴注。   此时硫酸镁可抑制中枢神经系统,松弛骨骼肌,具有镇静、抗痉挛以及减低颅内压等作用。常用于治疗惊厥、子痫、尿毒症、破伤风及高血压脑病等。   但应注意直接静脉注射或大剂量肌肉注射硫酸镁很危险,一般25%硫酸镁每次最多用15毫升即可。使用时应注意观察病人呼

①镇惊厥 

10%硫酸镁10毫升深部肌肉注射或用 5%葡萄糖稀释成2%~2.5%的溶液缓慢滴注。
 
此时硫酸镁可抑制中枢神经系统,松弛骨骼肌,具有镇静、抗痉挛以及减低颅内压等作用。常用于治疗惊厥、子痫、尿毒症、破伤风及高血压脑病等。
 
但应注意直接静脉注射或大剂量肌肉注射硫酸镁很危险,一般25%硫酸镁每次最多用15毫升即可。使用时应注意观察病人呼吸和血压情况,膝反射迟钝是镁离子足量的重要标志。
 
②通大便

口服硫酸镁在肠道吸收很少,口服硫酸镁有良好的导泻功能,因此硫酸镁又叫泻盐。
 
口服硫酸镁水溶液到达肠腔后,具有一定渗透压,使肠内水分不被肠壁吸收。
 
肠内保有大量水分,能机械地刺激肠的蠕动而排便。因此硫酸镁可用于治疗便秘、肠内异常发酵;与驱虫剂并用,可使肠虫易于排出。可每次将5 ~20克硫酸镁溶于100~400毫升温开水中,清晨一次口服。
 
③排结石

硫酸镁能刺激十二指肠粘膜,反射性地引起总胆管括约肌松弛、胆囊收缩,从而促进胆囊排空,有利胆之功效。可用于治疗胆囊炎胆石症,每次 2~5克,每日3次,饭前或餐间口服。
 
④降血压

对心血管系统的作用,注射给药,过量镁离子可直接扩张周围血管平滑肌,引起交感神经节传递障碍,从而血管扩张,血压下降。
 
肌内注射一次1g,10%溶液,每次10 毫升;
 
静脉滴注,一次1-2.5g,将25%溶液 10毫升用5%葡萄糖稀释成1%浓度缓慢注射。
 
⑤救哮喘

硫酸镁通过抑制细胞对钙的摄取而使支气管平滑肌松弛,有助于危重哮喘时症状的缓解。
 
药物剂量:25~40mg/(kg·d)(最大 2g/d),分1~2次,加入10%葡萄糖溶液20ml缓慢静脉滴注(20分钟以上),酌情使用1~3天。
 
⑥治早产

镁离子能直接抑制子宫平滑肌,可治疗早产。硫酸镁静脉注射与滴注,首次4克,用25%葡萄糖20毫升溶解5分钟内缓慢注射,以后用25%硫酸镁60 毫升,加于5%葡萄糖1000毫升静脉滴注,每小时2克,直到宫缩停止后2 小时。
 
但是,连续用药不能过长,有研究表明「暴露于镁超过1星期的新生儿与暴露于镁仅3天的新生儿相比,能够观察到其有显明更多的骨异常」可能是由于胎儿血镁过多和由此产生的低血钙症所致。
 
⑦低镁症

镁具有许多与钾相类似的生理功能。由于镁缺乏的临床表现与缺钾相似,故缺镁往往易被忽视。在缺钾时经过补钾而症状仍无改善时,应首先考虑到缺镁的可能,这样才可使低镁血症得到及时纠正。因此,长期输液的病人,在补钾的同时要注意补镁。每日输液中加1克硫酸镁,可防止低镁血症的发生。
 
⑧消炎去肿

硫酸镁有消炎去肿的功效,所以50% 硫酸镁溶液热敷患处可以消肿。
 
注意:

血镁过量可引起呼吸抑制、血压骤降、心跳骤停而致死。肌腱反射消失是呼吸抑制的先兆,因此,在连续用药期间应经常检查腱反射。出现中毒时应立即进行人工呼吸,并缓慢静脉注射氯化钙或葡萄糖酸钙紧急抢救。透析疗法可迅速清除体内镁离子,加速镁离子排泄。

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    2015-12-27 hixiaoluo

    好文章,值得收藏

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=49155, encodeId=39844915524, content=好文章,值得收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sun Dec 27 09:11:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=49156, encodeId=30bb49156f8, content=好文章,值得收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sun Dec 27 09:11:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44692, encodeId=a9d244692c6, content=内服外用?, beContent=null, objectType=article, channel=null, level=null, likeNumber=147, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Fri Dec 04 06:52:00 CST 2015, time=2015-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1445725, encodeId=089d1445e257e, content=<a href='/topic/show?id=6634e3575cf' target=_blank style='color:#2F92EE;'>#硫酸镁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73575, encryptionId=6634e3575cf, topicName=硫酸镁)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a0f15173844, createdName=xxxx1051, createdTime=Fri Dec 04 05:57:00 CST 2015, time=2015-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44523, encodeId=54804452340, content=我觉得镁剂有待深入研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJXCR8W80NNgQuicJU3aIm3JtiaNAFLYSMlBuVfGkSlw5Z5VpmZK4PyiaDURLAorhvwhWVnaM1gQdJXA/132, createdBy=a01444383, createdName=lixh1719, createdTime=Thu Dec 03 11:28:00 CST 2015, time=2015-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44501, encodeId=ca82445019b, content=收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=177, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhRUzmFEmHvdIaOns4DmF3BicVffXjkOjBTiaMUIA4o7feGvE5IJ0SfSco4ib955Rx7bvWlib7j9V15xp/0, createdBy=814d1631326, createdName=cmn, createdTime=Thu Dec 03 09:42:00 CST 2015, time=2015-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44487, encodeId=e76b4448ed6, content=物美价廉的好药, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d9077449, createdName=lpapple, createdTime=Thu Dec 03 06:50:00 CST 2015, time=2015-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44476, encodeId=3b29444e63e, content=有道理, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200609/ef6a57dbe7f1489dad7446b7c5217858/d5e4fe65996c4446a029b0f5d056abb1.jpg, createdBy=6b011518214, createdName=午夜星河, createdTime=Wed Dec 02 22:19:00 CST 2015, time=2015-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44416, encodeId=031e4441620, content=药理学过, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=974f1667182, createdName=杨晨舟, createdTime=Wed Dec 02 15:46:00 CST 2015, time=2015-12-02, status=1, ipAttribution=)]
    2015-12-27 hixiaoluo

    好文章,值得收藏

    0

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    2015-12-04 老段

    内服外用?

    0

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  5. [GetPortalCommentsPageByObjectIdResponse(id=49155, encodeId=39844915524, content=好文章,值得收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sun Dec 27 09:11:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=49156, encodeId=30bb49156f8, content=好文章,值得收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sun Dec 27 09:11:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44692, encodeId=a9d244692c6, content=内服外用?, beContent=null, objectType=article, channel=null, level=null, likeNumber=147, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Fri Dec 04 06:52:00 CST 2015, time=2015-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1445725, encodeId=089d1445e257e, content=<a href='/topic/show?id=6634e3575cf' target=_blank style='color:#2F92EE;'>#硫酸镁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73575, encryptionId=6634e3575cf, topicName=硫酸镁)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a0f15173844, createdName=xxxx1051, createdTime=Fri Dec 04 05:57:00 CST 2015, time=2015-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44523, encodeId=54804452340, content=我觉得镁剂有待深入研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJXCR8W80NNgQuicJU3aIm3JtiaNAFLYSMlBuVfGkSlw5Z5VpmZK4PyiaDURLAorhvwhWVnaM1gQdJXA/132, createdBy=a01444383, createdName=lixh1719, createdTime=Thu Dec 03 11:28:00 CST 2015, time=2015-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44501, encodeId=ca82445019b, content=收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=177, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhRUzmFEmHvdIaOns4DmF3BicVffXjkOjBTiaMUIA4o7feGvE5IJ0SfSco4ib955Rx7bvWlib7j9V15xp/0, createdBy=814d1631326, createdName=cmn, createdTime=Thu Dec 03 09:42:00 CST 2015, time=2015-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44487, encodeId=e76b4448ed6, content=物美价廉的好药, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d9077449, createdName=lpapple, createdTime=Thu Dec 03 06:50:00 CST 2015, time=2015-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44476, encodeId=3b29444e63e, content=有道理, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200609/ef6a57dbe7f1489dad7446b7c5217858/d5e4fe65996c4446a029b0f5d056abb1.jpg, createdBy=6b011518214, createdName=午夜星河, createdTime=Wed Dec 02 22:19:00 CST 2015, time=2015-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44416, encodeId=031e4441620, content=药理学过, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=974f1667182, createdName=杨晨舟, createdTime=Wed Dec 02 15:46:00 CST 2015, time=2015-12-02, status=1, ipAttribution=)]
    2015-12-03 lixh1719

    我觉得镁剂有待深入研究

    0

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    2015-12-03 cmn

    收藏

    0

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    2015-12-03 lpapple

    物美价廉的好药

    0

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    2015-12-02 午夜星河

    有道理

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=49155, encodeId=39844915524, content=好文章,值得收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sun Dec 27 09:11:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=49156, encodeId=30bb49156f8, content=好文章,值得收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=137, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sun Dec 27 09:11:00 CST 2015, time=2015-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44692, encodeId=a9d244692c6, content=内服外用?, beContent=null, objectType=article, channel=null, level=null, likeNumber=147, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d331664955, createdName=老段, createdTime=Fri Dec 04 06:52:00 CST 2015, time=2015-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1445725, encodeId=089d1445e257e, content=<a href='/topic/show?id=6634e3575cf' target=_blank style='color:#2F92EE;'>#硫酸镁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73575, encryptionId=6634e3575cf, topicName=硫酸镁)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a0f15173844, createdName=xxxx1051, createdTime=Fri Dec 04 05:57:00 CST 2015, time=2015-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44523, encodeId=54804452340, content=我觉得镁剂有待深入研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJXCR8W80NNgQuicJU3aIm3JtiaNAFLYSMlBuVfGkSlw5Z5VpmZK4PyiaDURLAorhvwhWVnaM1gQdJXA/132, createdBy=a01444383, createdName=lixh1719, createdTime=Thu Dec 03 11:28:00 CST 2015, time=2015-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44501, encodeId=ca82445019b, content=收藏, beContent=null, objectType=article, channel=null, level=null, likeNumber=177, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhRUzmFEmHvdIaOns4DmF3BicVffXjkOjBTiaMUIA4o7feGvE5IJ0SfSco4ib955Rx7bvWlib7j9V15xp/0, createdBy=814d1631326, createdName=cmn, createdTime=Thu Dec 03 09:42:00 CST 2015, time=2015-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44487, encodeId=e76b4448ed6, content=物美价廉的好药, beContent=null, objectType=article, channel=null, level=null, likeNumber=134, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6d9077449, createdName=lpapple, createdTime=Thu Dec 03 06:50:00 CST 2015, time=2015-12-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44476, encodeId=3b29444e63e, content=有道理, beContent=null, objectType=article, channel=null, level=null, likeNumber=121, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200609/ef6a57dbe7f1489dad7446b7c5217858/d5e4fe65996c4446a029b0f5d056abb1.jpg, createdBy=6b011518214, createdName=午夜星河, createdTime=Wed Dec 02 22:19:00 CST 2015, time=2015-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=44416, encodeId=031e4441620, content=药理学过, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=974f1667182, createdName=杨晨舟, createdTime=Wed Dec 02 15:46:00 CST 2015, time=2015-12-02, status=1, ipAttribution=)]
    2015-12-02 杨晨舟

    药理学过

    0

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