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Cancer Cell:癌症外染色体微小分子新功能

2014-10-29 佚名 生物谷

近日研究发现,通过癌细胞释放的外染色体、微小的病毒型颗粒可以表达导致肿瘤生长的微RNA分子。通过Dicer蛋白质的帮助他们进行了该研究,研究人员表明,Dicer也可以作为一种生物标志物对诊断和治疗乳腺癌开辟新的途径。调查结果发表在《癌症细胞》上。 “当Dicer和其他蛋白质与微RNA的存在发展相关时,来自乳腺癌患者细胞和血清的外染色体已被证明在非肿瘤细胞形成时启动肿瘤细胞生长。”Raghu

近日研究发现,通过癌细胞释放的外染色体、微小的病毒型颗粒可以表达导致肿瘤生长的微RNA分子。通过Dicer蛋白质的帮助他们进行了该研究,研究人员表明,Dicer也可以作为一种生物标志物对诊断和治疗乳腺癌开辟新的途径。调查结果发表在《癌症细胞》上。

“当Dicer和其他蛋白质与微RNA的存在发展相关时,来自乳腺癌患者细胞和血清的外染色体已被证明在非肿瘤细胞形成时启动肿瘤细胞生长。”Raghu Kalluri医学博士说,“这些发现为以外来染色体为基础的生物标记的发展提供机会并解释了癌症扩散的机制。”

外染色体是由DNA,RNA和蛋白质组成的小囊泡,它们附着在两个脂质层膜之间。这些外染色体拥有特殊功能如凝固、细胞间信号传导和细胞“垃圾管理”。“它们脱落进入到体液中形成核酸和蛋白质特异疾病的来源。越来越多的外染色体因其作为潜在疾病的指标而被研究,这将成为一种潜在的治疗方法。

所有Dicer含有更小的成分包括蛋白质,信使核糖核酸(mRNA)和小RNA。Kalluri的研究小组报告说,与乳腺癌关联的外染色体含有特定的小RNA与多重蛋白质,被称为RNA诱导的沉默复杂关联(RISC)。除了RISC,乳腺癌关联的外染色还含有Dicer和另外两个蛋白质,AGO2 TRBP,所有这些因素共同促使肿瘤生长。

“小RNA与外染色体的作用在癌症的发展过程中很大程度上是未知的。许多研究表明,推测存在外染色体中的小RNA的功能,“Kalluri说。“我们证明在癌症外染色体显著影响肿瘤的生长过程中抑制Dicer的功能,提高小RNA在外染色体中有助于癌症进展可能性。”

“这些研究反映了评估小RNA作用机制在外染色体和它们在肿瘤进展和转移时功能的需要,“Kalluri说。

原始出处

Raghu Kalluri, M.D., Ph.D. et al. Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis. Cancer Cell.2014

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    2014-11-23 宋威
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  5. [GetPortalCommentsPageByObjectIdResponse(id=1914608, encodeId=a4ca191460816, content=<a href='/topic/show?id=84d7469559b' target=_blank style='color:#2F92EE;'>#小分子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46955, encryptionId=84d7469559b, topicName=小分子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6105386, createdName=宋威, createdTime=Sun Nov 23 20:10:00 CST 2014, time=2014-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1868932, encodeId=1ab91868932fc, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Wed Aug 12 14:10:00 CST 2015, time=2015-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1780642, encodeId=f7bb1e806422b, content=<a href='/topic/show?id=517a4016ac' target=_blank style='color:#2F92EE;'>#cancer cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4016, encryptionId=517a4016ac, topicName=cancer cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=96f62500201, createdName=12498e67m28暂无昵称, createdTime=Tue May 26 23:10:00 CST 2015, time=2015-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1923887, encodeId=8550192388ecd, content=<a href='/topic/show?id=002658104e8' target=_blank style='color:#2F92EE;'>#新功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58104, encryptionId=002658104e8, topicName=新功能)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/L2dMhrxjvSWuPWKZZP1I83Rw21EWia7LVTYJibLQkb4oTibrYLwhnAXntTBWR3FruIzKfNMiaBwhYV0AKNmiaNxfialg/132, createdBy=6ea92500119, createdName=ms9608593228839890, createdTime=Fri Dec 05 06:10:00 CST 2014, time=2014-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1959178, encodeId=969f19591e88f, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Sun Feb 22 17:10:00 CST 2015, time=2015-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=12536, encodeId=d3921253661, content=这文章是机器翻译的么???, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d1e107368, createdName=boborush, createdTime=Mon Nov 17 16:05:00 CST 2014, time=2014-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1331597, encodeId=ed0f133159e00, content=<a href='/topic/show?id=d85a6181e4d' target=_blank style='color:#2F92EE;'>#染色体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61817, encryptionId=d85a6181e4d, topicName=染色体)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKnILSXam1GxPwj04ylEzibYLFA2eGl5Ev02klt80JA0xejMPqrn0mYHNNnLEgyqYTPbicXpY3tn6SA/132, createdBy=38fd2500059, createdName=新生儿张玉军, createdTime=Fri Oct 31 00:10:00 CST 2014, time=2014-10-31, status=1, ipAttribution=)]
    2015-02-22 维他命
  6. [GetPortalCommentsPageByObjectIdResponse(id=1914608, encodeId=a4ca191460816, content=<a href='/topic/show?id=84d7469559b' target=_blank style='color:#2F92EE;'>#小分子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46955, encryptionId=84d7469559b, topicName=小分子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6105386, createdName=宋威, createdTime=Sun Nov 23 20:10:00 CST 2014, time=2014-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1868932, encodeId=1ab91868932fc, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Wed Aug 12 14:10:00 CST 2015, time=2015-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1780642, encodeId=f7bb1e806422b, content=<a href='/topic/show?id=517a4016ac' target=_blank style='color:#2F92EE;'>#cancer cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4016, encryptionId=517a4016ac, topicName=cancer cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=96f62500201, createdName=12498e67m28暂无昵称, createdTime=Tue May 26 23:10:00 CST 2015, time=2015-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1923887, encodeId=8550192388ecd, content=<a href='/topic/show?id=002658104e8' target=_blank style='color:#2F92EE;'>#新功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58104, encryptionId=002658104e8, topicName=新功能)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/L2dMhrxjvSWuPWKZZP1I83Rw21EWia7LVTYJibLQkb4oTibrYLwhnAXntTBWR3FruIzKfNMiaBwhYV0AKNmiaNxfialg/132, createdBy=6ea92500119, createdName=ms9608593228839890, createdTime=Fri Dec 05 06:10:00 CST 2014, time=2014-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1959178, encodeId=969f19591e88f, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Sun Feb 22 17:10:00 CST 2015, time=2015-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=12536, encodeId=d3921253661, content=这文章是机器翻译的么???, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2d1e107368, createdName=boborush, createdTime=Mon Nov 17 16:05:00 CST 2014, time=2014-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1331597, encodeId=ed0f133159e00, content=<a href='/topic/show?id=d85a6181e4d' target=_blank style='color:#2F92EE;'>#染色体#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61817, encryptionId=d85a6181e4d, topicName=染色体)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKnILSXam1GxPwj04ylEzibYLFA2eGl5Ev02klt80JA0xejMPqrn0mYHNNnLEgyqYTPbicXpY3tn6SA/132, createdBy=38fd2500059, createdName=新生儿张玉军, createdTime=Fri Oct 31 00:10:00 CST 2014, time=2014-10-31, status=1, ipAttribution=)]
    2014-11-17 boborush

    这文章是机器翻译的么???

    0

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