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Sci Rep:鉴定治疗响应的基因特性来指导透明细胞肾细胞肿瘤的精准的肿瘤学研究

2020-02-20 AlexYang MedSci原创

透明细胞肾细胞癌(ccRCC)是一种常见抗性疾病,并且具有异常的血管生成和免疫抑制特征。患有转移性疾病的患者可根据临床特征进行治疗:低风险患者通常使用抗血管生成药物,中/高风险患者通常使用免疫治疗。然而,目前还没有可使用的生物标记来指导这些患者进行治疗的选择。最近,一个发表的临床II期试验观察到了ccRCC患者的聚类与靶向治疗响应存在联系。然而,这些组别的聚类并不清晰。因此,有研究人员对469名c

透明细胞肾细胞癌(ccRCC)是一种常见抗性疾病,并且具有异常的血管生成和免疫抑制特征。患有转移性疾病的患者可根据临床特征进行治疗:低风险患者通常使用抗血管生成药物,中/高风险患者通常使用免疫治疗。然而,目前还没有可使用的生物标记来指导这些患者进行治疗的选择。

最近,一个发表的临床II期试验观察到了ccRCC患者的聚类与靶向治疗响应存在联系。然而,这些组别的聚类并不清晰。因此,有研究人员对469名ccRCC患者进行了基因表达分析,并利用特征选择技术开发了一个相对准确的包含66个基因特征方法来改善对患者的亚群分类。更多的是,研究人员鉴定了一个新的综合的表达情况来区分迁移的基质细胞和免疫细胞。进一步的是,设计的66个基因特征在一个包含64名ccRCC患者群体中进一步得到了验证。

最后,研究人员指出,他们的发现对可依赖的生物标记的开发奠定了基础,并且能够指导治疗决定并改善ccRCC患者的治疗响应。

原始出处:

Ninadh M. D'Costa, Davide Cina, Raunak Shrestha et al. Identification of gene signature for treatment response to guide precision oncology in clear-cell renal cell carcinoma. Sci Rep. 06 Feb 2020

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