Baidu
map

Alz Res Therapy:白质高信号和痴呆影像指标,关系千丝万缕

2021-11-05 Freeman MedSci原创

该结果强调了WMH的模式特异性分布模式,这些模式在后部白质中汇聚。

白质高信号(WMH),使用(FLAIR)磁共振成像(MRI)进行量化,被认为是脑血管疾病的一个标志,与年龄和心血管危险因素密切相关。WMH的存在也与较低的认知能力和临床阿尔茨海默病(AD)的风险增加有关,这表明WM损伤参与了AD的发病机制。

以前的研究表明,使用敏感PET、脑脊液(CSF)或磁共振成像(MRI)生物标志物测量,WM病理学可能与β-淀粉样蛋白(Aβ)斑块、tau缠结和神经变性的病理标志物直接相关。因此,在一些横断面研究中,WMH的更大存在和延伸与更大的Aβ沉积有关,尽管没有一致的发现,以及在通常受AD影响的脑区,葡萄糖代谢更低,灰质体积(GMV)减少。同时,tau病理与全球(全脑)或区域WMH的关系并不一致,一些作者报告了影响,而其他作者没有发现。


在现有的文献中,全局WMH描述符经常被用来量化WM病理学,并评估其与AD的大脑生物标志物的关系。这种方法掩盖了特定区域的影响。因此,最近使用了voxel-wise mapping 方法来确定与Aβ和/或tau负担有关的WM病变的分布模式。这些独立的队列研究结果为脑室周围后部区域参与Aβ沉积和区域WMH之间的关联提供了一致的支持,而这一点在Tau负担中并没有看到。同样,最近的一项研究表明,在Aβ沉积异常的个体中,WM后部的改变(由平均弥散率和WMH评估)在整个生命周期内随年龄而增加。

藉此,德国柏林大学的Malo Gaubert等人,研究了WMH的空间分布,即使用感兴趣区域(ROI)和体素水平的方法来确定,与新皮质Aβ负担、颞-顶叶代谢低下和内侧-颞GMV减少之间的联系。

共155名参与者(IMAP+队列),从正常认知到AD痴呆,获得FLAIR MRI、AV45-PET、FDG-PET和T1 MRI。从FLAIR图像中自动分割出WMH。使用已建立的AD元特征模板从处理过的图像中提取新皮质Aβ沉积(AV45-PET)、颞顶葡萄糖代谢(FDG-PET)和内侧-颞部灰质体积(GMV)的平均水平。在调整了年龄、性别、教育和收缩压的情况下,研究了AD大脑生物标志物和WMH之间的关系,按兴趣区域和体素评估。

他们发现:全局的Aβ负担和特定区域的WMH之间没有明显的联系。胼胝体中的体素WMH和阈值下更大的Aβ沉积有关。胼胝体后部以及顶叶、枕叶和额叶区域基于区域和体素的WMH与颞顶叶的葡萄糖代谢降低有关。

同样,内侧-颞侧GMV的降低与胼胝体后部的WMH以及顶叶、枕叶和额叶区域的WMH相关。

这项研究表明,局部白质损伤与AD的多模式大脑生物标志物相关。该结果强调了WMH的模式特异性分布模式,这些模式在后部白质中汇聚。这些横断面研究结果证实了区域性WMH与AD典型的Aβ沉积和神经变性的关联。

原文出处:

Gaubert M, Lange C, Garnier-Crussard A, et al. Topographic patterns of white matter hyperintensities are associated with multimodal neuroimaging biomarkers of Alzheimer’s disease. Alz Res Therapy. 2021;13(1):29. doi:10.1186/s13195-020-00759-3

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1739072, encodeId=a3461e3907267, content=<a href='/topic/show?id=6e566913df' target=_blank style='color:#2F92EE;'>#ERA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6913, encryptionId=6e566913df, topicName=ERA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e36234488643, createdName=124988c7m106暂无昵称, createdTime=Sat Jul 23 11:10:43 CST 2022, time=2022-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1950842, encodeId=03f61950842fa, content=<a href='/topic/show?id=20101021e97e' target=_blank style='color:#2F92EE;'>#高信号#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102179, encryptionId=20101021e97e, topicName=高信号)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=08e4137, createdName=meichuangyi, createdTime=Mon Mar 28 05:10:43 CST 2022, time=2022-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1765921, encodeId=d50f1e6592128, content=<a href='/topic/show?id=252ae1803a3' target=_blank style='color:#2F92EE;'>#白质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71803, encryptionId=252ae1803a3, topicName=白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Mon Mar 07 08:10:43 CST 2022, time=2022-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1417586, encodeId=6873141e5862a, content=<a href='/topic/show?id=c667e181616' target=_blank style='color:#2F92EE;'>#白质高信号#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71816, encryptionId=c667e181616, topicName=白质高信号)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=44693296090, createdName=zhangph, createdTime=Sun Nov 07 21:10:43 CST 2021, time=2021-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1246337, encodeId=ce3a124633ecd, content=老年性痴呆,未来还是希望借助神经电生理吧,也许更为有效!, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=neuro.Dr, createdTime=Sat Nov 06 09:10:43 CST 2021, time=2021-11-06, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1739072, encodeId=a3461e3907267, content=<a href='/topic/show?id=6e566913df' target=_blank style='color:#2F92EE;'>#ERA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6913, encryptionId=6e566913df, topicName=ERA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e36234488643, createdName=124988c7m106暂无昵称, createdTime=Sat Jul 23 11:10:43 CST 2022, time=2022-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1950842, encodeId=03f61950842fa, content=<a href='/topic/show?id=20101021e97e' target=_blank style='color:#2F92EE;'>#高信号#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102179, encryptionId=20101021e97e, topicName=高信号)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=08e4137, createdName=meichuangyi, createdTime=Mon Mar 28 05:10:43 CST 2022, time=2022-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1765921, encodeId=d50f1e6592128, content=<a href='/topic/show?id=252ae1803a3' target=_blank style='color:#2F92EE;'>#白质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71803, encryptionId=252ae1803a3, topicName=白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Mon Mar 07 08:10:43 CST 2022, time=2022-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1417586, encodeId=6873141e5862a, content=<a href='/topic/show?id=c667e181616' target=_blank style='color:#2F92EE;'>#白质高信号#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71816, encryptionId=c667e181616, topicName=白质高信号)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=44693296090, createdName=zhangph, createdTime=Sun Nov 07 21:10:43 CST 2021, time=2021-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1246337, encodeId=ce3a124633ecd, content=老年性痴呆,未来还是希望借助神经电生理吧,也许更为有效!, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=neuro.Dr, createdTime=Sat Nov 06 09:10:43 CST 2021, time=2021-11-06, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1739072, encodeId=a3461e3907267, content=<a href='/topic/show?id=6e566913df' target=_blank style='color:#2F92EE;'>#ERA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6913, encryptionId=6e566913df, topicName=ERA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e36234488643, createdName=124988c7m106暂无昵称, createdTime=Sat Jul 23 11:10:43 CST 2022, time=2022-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1950842, encodeId=03f61950842fa, content=<a href='/topic/show?id=20101021e97e' target=_blank style='color:#2F92EE;'>#高信号#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102179, encryptionId=20101021e97e, topicName=高信号)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=08e4137, createdName=meichuangyi, createdTime=Mon Mar 28 05:10:43 CST 2022, time=2022-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1765921, encodeId=d50f1e6592128, content=<a href='/topic/show?id=252ae1803a3' target=_blank style='color:#2F92EE;'>#白质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71803, encryptionId=252ae1803a3, topicName=白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Mon Mar 07 08:10:43 CST 2022, time=2022-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1417586, encodeId=6873141e5862a, content=<a href='/topic/show?id=c667e181616' target=_blank style='color:#2F92EE;'>#白质高信号#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71816, encryptionId=c667e181616, topicName=白质高信号)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=44693296090, createdName=zhangph, createdTime=Sun Nov 07 21:10:43 CST 2021, time=2021-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1246337, encodeId=ce3a124633ecd, content=老年性痴呆,未来还是希望借助神经电生理吧,也许更为有效!, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=neuro.Dr, createdTime=Sat Nov 06 09:10:43 CST 2021, time=2021-11-06, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1739072, encodeId=a3461e3907267, content=<a href='/topic/show?id=6e566913df' target=_blank style='color:#2F92EE;'>#ERA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6913, encryptionId=6e566913df, topicName=ERA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e36234488643, createdName=124988c7m106暂无昵称, createdTime=Sat Jul 23 11:10:43 CST 2022, time=2022-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1950842, encodeId=03f61950842fa, content=<a href='/topic/show?id=20101021e97e' target=_blank style='color:#2F92EE;'>#高信号#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102179, encryptionId=20101021e97e, topicName=高信号)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=08e4137, createdName=meichuangyi, createdTime=Mon Mar 28 05:10:43 CST 2022, time=2022-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1765921, encodeId=d50f1e6592128, content=<a href='/topic/show?id=252ae1803a3' target=_blank style='color:#2F92EE;'>#白质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71803, encryptionId=252ae1803a3, topicName=白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Mon Mar 07 08:10:43 CST 2022, time=2022-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1417586, encodeId=6873141e5862a, content=<a href='/topic/show?id=c667e181616' target=_blank style='color:#2F92EE;'>#白质高信号#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71816, encryptionId=c667e181616, topicName=白质高信号)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=44693296090, createdName=zhangph, createdTime=Sun Nov 07 21:10:43 CST 2021, time=2021-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1246337, encodeId=ce3a124633ecd, content=老年性痴呆,未来还是希望借助神经电生理吧,也许更为有效!, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=neuro.Dr, createdTime=Sat Nov 06 09:10:43 CST 2021, time=2021-11-06, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1739072, encodeId=a3461e3907267, content=<a href='/topic/show?id=6e566913df' target=_blank style='color:#2F92EE;'>#ERA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6913, encryptionId=6e566913df, topicName=ERA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e36234488643, createdName=124988c7m106暂无昵称, createdTime=Sat Jul 23 11:10:43 CST 2022, time=2022-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1950842, encodeId=03f61950842fa, content=<a href='/topic/show?id=20101021e97e' target=_blank style='color:#2F92EE;'>#高信号#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102179, encryptionId=20101021e97e, topicName=高信号)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=08e4137, createdName=meichuangyi, createdTime=Mon Mar 28 05:10:43 CST 2022, time=2022-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1765921, encodeId=d50f1e6592128, content=<a href='/topic/show?id=252ae1803a3' target=_blank style='color:#2F92EE;'>#白质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71803, encryptionId=252ae1803a3, topicName=白质)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Mon Mar 07 08:10:43 CST 2022, time=2022-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1417586, encodeId=6873141e5862a, content=<a href='/topic/show?id=c667e181616' target=_blank style='color:#2F92EE;'>#白质高信号#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71816, encryptionId=c667e181616, topicName=白质高信号)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=44693296090, createdName=zhangph, createdTime=Sun Nov 07 21:10:43 CST 2021, time=2021-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1246337, encodeId=ce3a124633ecd, content=老年性痴呆,未来还是希望借助神经电生理吧,也许更为有效!, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=neuro.Dr, createdTime=Sat Nov 06 09:10:43 CST 2021, time=2021-11-06, status=1, ipAttribution=)]
    2021-11-06 neuro.Dr

    老年性痴呆,未来还是希望借助神经电生理吧,也许更为有效!

    0

相关资讯

Alz Res Therapy:额颞叶痴呆,临床进展和治疗有何特点

FTD综合征在基线特征、进展率和治疗方面与AD不同

Alz Res Therapy:复旦大学-上海衰老研究,肾脏功能减退和痴呆息息相关

GFR-crcys可被认为是个人认知能力下降风险的标志。

Alz Res Therapy:老年痴呆患者,血液和尿液血清素更低

与对照组相比,AD患者的尿液和血清5-羟色胺浓度明显较低

Alz Res Therapy:MRI新方法,有助于区分阿尔兹海默症和额颞叶痴呆

AD、FTD和正常老年人的脑萎缩显示出不同的模式

Alz Res Therapy:大脑功能网络变化,或可提前预测认知功能减退

基于fMRI的认知衰退的新的神经特征来自dfALFF和DFC的反复和并发模式

Alz Res Therapy:遗传性痴呆,tau蛋白的区域分布,和认知减退高度关联

该研究与横断面研究所暗示的ADAD的生物变化顺序一致,并强调EC tau作为早期生物标志物的重要性

拓展阅读

WCIRDC 2024 | 对话Harold T. Pretorius教授:正电子发射断层成像(PET)技术在老年痴呆早期诊断中的创新应用

正电子发射断层成像(PET)技术作为一种非侵入性的影像学工具,在老年痴呆的早期诊断中展现出巨大的潜力。

Lancet neurology:通过淀粉样蛋白 PET 和 tau PET 评估唐氏综合症患者出现症状性阿尔茨海默病的时间线

唐氏综合症患者从 β 淀粉样蛋白呈阳性和 tau 蛋白沉积开始,到最初的认知能力下降和痴呆的时间很短。

AD:区域脑血流量反映了阿尔茨海默病连续体的神经退行性变和微血管完整性

低灌注的空间模式可能会区分 AD 和 VRF 相关对局部 CBF 的影响。

Alzheimer&Dementia:神经丝和颗粒体蛋白前体与额颞叶变性的萎缩有关

神经丝和颗粒体蛋白前体与结构成像相互作用确定为监测疾病进展和治疗的有希望的候选者。

JAMA neurology:从虚弱到痴呆有多远?美国和英国痴呆症前的虚弱轨迹

衰弱测量可用于识别高危人群,以便优先参加痴呆症预防和治疗的临床试验。

IJNS:护士主导的分阶段综合艺术认知干预对老年痴呆症患者的影响

这项由护士主导的分阶段综合艺术认知干预项目的随机对照试验中,参与该项目的阿尔茨海默病老年患者的认知能力和心理健康有所改善。

2022 欧洲共识:MCI和轻度痴呆初级阶段的诊断和治疗

意大利阿尔兹海默病专家组 · 2022-10-09

适合痴呆症患者的急救护理:老年急救护理应用研究网络范围审查和共识会议的结果

急性期后和长期护理学会(AMDA,The Society for Post-Acute and Long-Term Care Medicine) · 2022-08-01

痴呆及阿尔茨海默病进展要点简析

四川大学华西医院 · 2022-07-26

Baidu
map
Baidu
map
Baidu
map