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Clin Exp Pharmacol Physiol:淫羊藿苷能够抑制组胺诱导的鼻粘膜上皮细胞炎症细胞因子和粘蛋白的表达

2019-06-29 AlexYang MedSci原创

过敏性鼻炎(AR)是一种呼吸道疾病,并且与慢性炎症相关。淫羊藿苷是一种天然香豆素衍生物,并且报道具有抗过敏和抗炎症作用。然而,淫羊藿苷在AR中的作用还没有研究。最近,有研究人员调查了淫羊藿苷对AR的影响。研究人员利用组胺对淫羊藿苷预处理过或者没有预处理过的人类鼻上皮细胞(HNEpC)进行持续24小时的刺激,并利用qRT-PCR和ELISA定量了相关细胞因子的mRNA水平和蛋白水平。研究发现,淫羊藿

过敏性鼻炎(AR)是一种呼吸道疾病,并且与慢性炎症相关。淫羊藿苷是一种天然香豆素衍生物,并且报道具有抗过敏和抗炎症作用。然而,淫羊藿苷在AR中的作用还没有研究。

最近,有研究人员调查了淫羊藿苷对AR的影响。研究人员利用组胺对淫羊藿苷预处理过或者没有预处理过的人类鼻上皮细胞(HNEpC)进行持续24小时的刺激,并利用qRT-PCR和ELISA定量了相关细胞因子的mRNA水平和蛋白水平。研究发现,淫羊藿苷能够抑制组胺诱导的IL-6、IL-8和MUC5AC在HNEpCs中的表达和分泌。更多的是,研究人员利用蛋白免疫印迹分析,通过检测NF-κB p65、p-p65和IκBα的表达调查了淫羊藿苷对NF-κB途径的影响。淫羊藿苷处理能够抑制组胺诱导的 p-p65表达和p-IκBα降解。抑制NF-κB途径能够抑制组胺诱导的 IL-6、IL-8和MUC5AC在HNEpCs中的产生。

最后,研究人员指出,他们的发现表明了淫羊藿苷能够抑制组胺诱导的炎症细胞因子和粘蛋白在HNEpCs中的产生,且可以部分的通过抑制NF-κB途径来进行调控。

原始出处:


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    2020-04-18 jml2009
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    2020-04-05 yb6560
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  5. 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  6. 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  7. 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  8. 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time=2020-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2046591, encodeId=a2d4204659169, content=<a href='/topic/show?id=4499e795592' target=_blank style='color:#2F92EE;'>#细胞炎症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77955, encryptionId=4499e795592, topicName=细胞炎症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca20190, createdName=wushaoling, createdTime=Mon Dec 09 15:05:00 CST 2019, time=2019-12-09, status=1, ipAttribution=)]
    2020-01-13 guoyibin
  9. 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【1】EBioMedicine:IL-2响应的减少与总lgE水平提高和过敏性鼻炎的加重相关 自身免疫和过敏与调节T细胞(Tregs)数目的减少和低水平的白介素-2(IL-2)相关。最近,有研究人员调查了在童年早期,是否病原气道细菌刺激外周血单核细胞(PBMCs)而释放的IL-2与过敏结果的发展相关。研究人员从331名6月大的婴幼儿中分离了PBMCs细胞,之后在体外利用流感嗜血杆菌、卡他拉

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最近,有研究人员调查了TLR4拮抗剂在卵清蛋白(OVA)诱导的并发过敏性鼻炎和哮喘综合症(CARAS)小鼠模型中的影响情况。研究人员建立了一个OVA诱导的小鼠CARAS模型,并将TLR4拮抗剂,TAK-242进行鼻内或者腹腔内注射,并利用流式细胞仪、蛋白免疫印迹和酶联免疫反应(ELISA)对不同细胞类型数目、相关蛋白的表达和相关白介素水平进行了检测。研究发现,TAK-242处理能够下调CCL2的表

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过敏性湿疹和食物过敏经常在儿童早期发生。然而,湿疹起始与过敏原敏感有关的特应性疾病的发生的相关性的关系仍旧不清楚。最近,有研究人员跟踪调查了186名儿童,跟踪调查为期4年。研究人员将儿童分成3个小组:早发性湿疹组(小于2岁,n=55),晚发性湿疹组(不小于2岁,n=40)和不具有湿疹组(n=91)。研究发现,在具有早发性湿疹组中,食物过敏,尤其是牛奶过敏患病率与1、1.5、2、3和4岁的没有湿疹的

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