JCEM：更年期激素治疗与心血管疾病

2021-02-03 MedSci原创 MedSci原创

尽管HT在绝经管理中仍发挥着重要作用，但不建议将其用于CVD的一级或二级预防。HT的不同制剂、剂量和给药途径对心脏代谢指标和临床CVD事件风险的影响不同。

近日，内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章，该小型系统评价旨在概述更年期激素治疗（HT）与心血管疾病（CVD）风险之间的关系，着重阐述了激素配方、剂量和给药途径的作用。

该系统评价是基于作者对更年期HT领域的知识，并对PubMed进行了检索，其使用了“更年期激素疗法”、“经皮”、“雌二醇”、“结合雌激素”、“生物同一性”、“心血管疾病”、“脂蛋白”、“葡萄糖”、“孕激素”、“低剂量”等检索词。

现有证据表明，口服抗雌激素对脂蛋白水平、血糖、胰岛素和CVD风险具有保护性作用，但是补充孕激素会减弱脂质相关的作用。减弱作用最小的孕激素剂型为微粉化的孕酮。与口服雌激素相比，经皮雌激素对凝血、炎症和脂质的影响较小，观察研究表明，与口服雌激素相比，它们引起VTE和卒中的风险更低。激素的临床效果并非一直呈剂量依赖性。

由此可见，尽管HT在绝经管理中仍发挥着重要作用，但不建议将其用于CVD的一级或二级预防。HT的不同制剂、剂量和给药途径对心脏代谢指标和临床CVD事件风险的影响不同。

原始出处：

Chrisandra L. Shufelt.et al.Menopausal Hormone Therapy and Cardiovascular Disease: The Role of Formulation, Dose, and Route of Delivery.JCEM.2021.https://doi.org/10.1210/clinem/dgab042

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2021-07-07 achengzhao

#JCE#

125 0
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2021-10-25 smallant2015

#JCEM#

76 0
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2021-03-23 病毒猎手

#激素替代治疗#

168 0
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2021-02-05 aliceclz

#激素治疗#

79 0
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2021-02-05 andy2090

#血管疾病#

74 0
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2021-02-04 carrotlyl

好文章

0 0
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2021-02-03 Aidy

尽管HT在绝经管理中仍发挥着重要作用，但不建议将其用于CVD的一级或二级预防。HT的不同制剂、剂量和给药途径对心脏代谢指标和临床CVD事件风险的影响不同

0 0
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2021-02-03 易水河

内分泌异常是个问题

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