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Int J Cardiol:急性冠状动脉综合征患者卒中的发生率和预测因素

2018-11-05 xing.T MedSci原创

由此可见,ACS后卒中的长期发生率为3.8%,AF患者为7.8%,无AF的患者为3.3%。

卒中是最令人恐惧的血管疾病之一,因为它具有高度的致残风险,并且其在急性冠状动脉综合征(ACS)后的发病率并不少见。

近日,血管领域权威杂志International Journal of Cardiology上发表了一篇研究文章,研究人员对在两家医院连续就诊的所有ACS患者进行了回顾性研究。将全因死亡率作为竞争事件的竞争风险回归用于评估卒中发病率。

研究人员纳入了8771例患者,房颤患病率为12.4%。AF患者年龄较大,心血管危险因素和既往心血管疾病患病率越高,并且肾小球滤过率较低。不到一半的AF患者在入院前接受口服抗凝治疗。院内死亡率为5.1%,AF患者的死亡率高出两倍多(10.2% vs. 4.4%; p<0.01)。在出院时观察到医学治疗的相关差异,并且在AF患者中口服抗凝剂的比例大约<50%。中位随访期间为58.7个月,313例患者至少发生一次卒中(发生率为3.8%,95%CI为3.4-4.2),AF患者高出2倍:7.8% vs. 3.3%(p<0.01)。首次卒中的中位时间为33.0(30.1)个月,AF患者与非AF患者相比时间更短(28.2±22.3 vs. 34.6±31.1; p<0.01)。调整后的竞争风险回归确定了AF、既往卒中和CHA2DS2-VASc评分=2或≥3作为卒中的独立预测因子; CHA2DS2-VASc评分=2仅与AF患者的卒中风险相关。

由此可见,ACS后卒中的长期发生率为3.8%,AF患者为7.8%,无AF的患者为3.3%。

原始出处:

AlbertoCordero,et al.Incidence and predictors of stroke in patients discharged with the diagnosis of acute coronary syndrome.International Journal of Cardiology.2018.https://doi.org/10.1016/j.ijcard.2018.10.082

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    2018-11-18 1245ff7am97暂无昵称

    房颤流行病学

    0

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    2018-11-05 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

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