Science：找到“病从口入”新说法，这次和肠道菌群有关

2017-11-26 佚名学术经纬

“病从口入”是小时候我们经常听到的教导。吃了不干净的东西肚子会疼的！不过最新的研究发现，我们口腔中正常存在的细菌，在引发炎症性肠病(inflammatory bowel diseases， IBD)方面也有意想不到的作用。日本庆应义塾大学(Keio University)医学部的研究人员在《科学》杂志上发表的一项研究表明，口腔中存在的肺炎克雷伯氏菌(Klebsiella pneumoniae)在肠

“病从口入”是小时候我们经常听到的教导。吃了不干净的东西肚子会疼的！不过最新的研究发现，我们口腔中正常存在的细菌，在引发炎症性肠病(inflammatory bowel diseases， IBD)方面也有意想不到的作用。日本庆应义塾大学(Keio University)医学部的研究人员在《科学》杂志上发表的一项研究表明，口腔中存在的肺炎克雷伯氏菌(Klebsiella pneumoniae)在肠道扎根落户会引发免疫细胞中的TH1辅助细胞(T helper 1)过度激活，导致肠道炎症和IBD的发生。

IBD和克罗恩病(Crohn's disease， CD)通常与肠道菌群失调有关。在这些患者的肠道中，研究人员经常发现，原本应当在口腔中存在的微生物的数量会增加。但是口腔微生物在肠道中的繁衍到底是导致IBD的原因？还是IBD造成的结果？这并没有得到明确的解答。

为了研究这个问题，研究人员将健康志愿者和两位IBD患者的唾液样本移植到无菌小鼠的胃中。他们发现，一位IBD患者唾液样本在移植到小鼠身上6周之后，导致小鼠肠道中的TH1辅助细胞显着增多。TH1辅助细胞通常的功能是通过释放interferon-gamma来激活巨噬细胞，增强杀菌作用，但是它们的过度激活也可能导致自身免疫疾病的产生。同时，对小鼠粪便的分析发现在口腔中通常出现的20多种细菌在肠道中显着增加。那么到底是哪一种口腔细菌是激活TH1辅助细胞的罪魁祸首呢？

▲健康人（He）与溃疡性结肠炎患者（UC）的肠道菌群分布（图片来源：《科学》）

研究人员将从小鼠粪便中检测到的口腔细菌分离培养，然后将分离出来的单一菌种分别移植到无菌小鼠中。通过这项试验，他们发现原来肺炎克雷伯氏菌在肠道扎根落户会导致TH1辅助细胞的过度激活。

肺炎克雷伯氏菌是健康人口腔中正常出现的菌种，虽然每天我们会吞咽1.5升的唾液，同时将大量细菌吞进肚里，但是通常肺炎克雷伯氏菌不会在肠道中过度繁衍。但是当由于使用青霉素或者其它原因导致肠道菌群失调，它们对肺炎克雷伯氏菌的抑制能力下降时，肺炎克雷伯氏菌就能够在肠道中繁衍并且激活TH1辅助细胞。“所以即便对健康人来说，也应该避免长期过度使用抗生素，”文章的资深作者之一，庆应义塾大学的Hattori教授说。

既然肺炎克雷伯氏菌可能是导致或者加重IBD的原因，那么我们能不能多刷刷牙，漱漱口，通过保持口腔卫生来防止IBD的发生呢？不幸的是，肺炎克雷伯氏菌对多种抗生素都产生了抗性，目前还没有一种有效的方法专门杀死或去除这种细菌。不过Hattori教授说：“我们的研究可以帮助开发靶向肺炎克雷伯氏菌的狭谱抗菌素和裂解噬菌体(lytic bacteriophages)，或者找出增强肠道菌群抑制口腔细菌增生的办法。这些方法都有可能帮助IBD患者。”

原始出处：Koji Atarashi, Wataru Suda, Chengwei Luo, et al. Ectopic colonization of oral bacteria in the intestine drives TH1 cell induction and inflammation. Science 20 Oct 2017

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2017-12-01 半夏微凉

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2017-11-27 jichang

#SCIE#

68 0
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2017-11-27 yfjms

学习

107 0
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2017-11-26 lyh994

人体内的蝴蝶效应

110 0
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2017-11-26 1ddf0692m34(暂无匿称)

学习了.涨知识

101 0
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2017-11-26 wqkm

^_^^_^^_^^_^

112 0
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2017-11-26 chunjianf

学习了'谢谢分享

67 0
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2017-11-26 zt123

vvccvvbbvcccd

62 0
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createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRk75KAEKrLGic0S0IvH1aNynsEFQWiaNKdtzvtwj2kafCoPg2icYVbrfBCFiaS74X1uEiaaTTY1H9Xyem/0, createdBy=cec11614828, createdName=chunjianf, createdTime=Sun Nov 26 08:04:33 CST 2017, time=2017-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264411, encodeId=8b8e264411d6, content=vvccvvbbvcccd, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaEKXpC8j9TaoCpG4yIB3skibUZ0ricmVQ6KKIVpqYQxINrmlibsPZSia7GOUupzuINf8UITMib8awsjjkPw/0, createdBy=abbf1713451, createdName=zt123, createdTime=Sun Nov 26 08:01:03 CST 2017, time=2017-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=264409, encodeId=e4ef2644091e, content=优质资源.共同学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K0LqDY57Aia0TOQByoJhNt3icm4sfukp500hLH6RHOpFdV01NbECtAV7s0qKpQPibyRukQAwAmqJU3X/0, createdBy=f91f1928792, createdName=九九消寒, createdTime=Sun Nov 26 07:54:13 CST 2017, time=2017-11-26, status=1, ipAttribution=)]
2017-11-26 九九消寒

优质资源.共同学习

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