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Nat Commun:我国急性腹泻的病原学、流行病学和临床特征研究

2021-05-04 haibei MedSci原创

最近,研究人员在Nature Communications杂志发文,报告了入选该分析的152,792名合格患者的病原学、流行病学和临床特征。

尽管人们已经在环境卫生状况和公共卫生意识方面取得了重大进展,但腹泻仍然是全世界疾病负担的主要原因之一。2016年,全世界因腹泻而发生的病例超过44亿,死亡人数超过160万。腹泻在生命损失的常见原因中排名第八,造成了大量的医疗和保健费用,对社会的经济影响很大。

有证据表明,腹泻病是导致儿科发病率和死亡率的主要因素,特别是在低收入和中等收入国家(LMICs)。2017年,全球5岁以下儿童因腹泻死亡的人数超过50万,其中88%发生在南亚和撒哈拉以南的非洲。

急性腹泻的病因在不同地区有所不同,取决于经济发展、当地气候和地理环境。更好地了解急性腹泻的流行病学、病因学和季节性,对规划和采取有针对性的预防措施以及抗菌治疗很有价值。

2009-2018年间,我国对全年龄段的急性腹泻患者进行了全国性的前瞻性监测。最近,研究人员在Nature Communications杂志发文,报告了入选该分析的152,792名合格患者的病原学、流行病学和临床特征。

 2009-2018年中国大陆各年龄段腹泻患者肠道病原体的病原谱和合并感染模式

结果显示,轮状病毒A和诺如病毒是在患者中检测到的两种主要病毒病原体,其次是腺病毒和天疱疮病毒。腹泻性大肠杆菌和非伤寒沙门氏菌是两种主要的细菌病原体,其次是志贺氏菌和副溶血性弧菌。

年龄小于5岁的患者的病毒性病原体总体阳性率较高,而细菌性病原体在18-45岁的患者中更常见。此外,连接点分析显示了特定年龄段的阳性率,以及个别病原体的阳性率如何变化。

因此,该研究结果填补了中国腹泻患者的肠道病原体分布如何变化的关键空白。这有助于在临床实践中更好地确定主要的腹泻病原体候选诊断,并更有针对性地应用预防和控制措施。

 

原始出处:

Li-Ping Wang et al. Etiological, epidemiological, and clinical features of acute diarrhea in China. Nature Communications (2021). 

 

 

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    2021-10-12 liye789132251
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    2021-11-23 liuli5079
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    2021-05-06 xugumin
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    2021-05-06 gjsgj

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