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BJC:乳腺癌患者骨折风险研究

2016-10-07 Mechront 译 MedSci原创

骨折可能对乳腺癌的预后有影响。乳腺癌患者骨折的长期风险还没有得到深入的研究。 基于瑞典国家登记数据,我们使用泊松回归,对乳腺癌和非乳腺癌参与者数据进行了分析,比较两组人群的骨折住院治疗发生率。使用Cox回归分析调查与乳腺癌患者骨折住院治疗、随后死亡风险相关的危险因素。 数据显示,对于乳腺癌患者,5年骨折住院风险为4.8%,骨折住院后30天死亡风险为2.0%。 与普通人群相比,乳腺

骨折可能对乳腺癌的预后有影响。乳腺癌患者骨折的长期风险还没有得到深入的研究。

基于瑞典国家登记数据,我们使用泊松回归,对乳腺癌和非乳腺癌参与者数据进行了分析,比较两组人群的骨折住院治疗发生率。使用Cox回归分析调查与乳腺癌患者骨折住院治疗、随后死亡风险相关的危险因素。

数据显示,对于乳腺癌患者,5年骨折住院风险为4.8%,骨折住院后30天死亡风险为2.0%。

与普通人群相比,乳腺癌患者任何骨折住院治疗的IRR值为1.25 (95% CI: 1.23–1.28);因髋部骨折住院治疗的IRR值为1.18 (95% CI: 1.14–1.22)。

10年后这些比率仍然显着增加。

合并症(Charlson合并症指数大于或等于1)与骨折住院治疗风险相关。

服用芳香化酶抑制剂的女性与服用他莫昔芬的女性相比,风险更高(HR=1.48; 95% CI: 0.98–2.22)。

乳腺癌患者中,骨折住院治疗患者与非骨折患者相比,死亡风险更高(HR=1.83; 95% CI: 1.50–2.22)。

研究结果表明,乳腺癌患者的骨折住院的风险增加,尤其是患者还存在其他合并症时。

原始出处:


Edoardo Colzani,et al.Risk of hospitalisation and death due to bone fractures after breast cancer: a registry-based cohort study.British Journal of Cancer advance online publication 4 October 2016

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  2. [GetPortalCommentsPageByObjectIdResponse(id=2055602, encodeId=05c0205560271, content=<a href='/topic/show?id=734110089320' target=_blank style='color:#2F92EE;'>#风险研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100893, encryptionId=734110089320, topicName=风险研究)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Sun May 28 05:57:00 CST 2017, time=2017-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201370, encodeId=b0c72013e0c2, content=感谢分享一下!, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=20971999626, createdName=laymankey, createdTime=Mon May 22 23:58:54 CST 2017, time=2017-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=145319, encodeId=9f6614531930, content=好文章,受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Oct 11 20:14:18 CST 2016, time=2016-10-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=143068, encodeId=9afa1430682e, content=文章很好,继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Mon Oct 10 10:53:52 CST 2016, time=2016-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=142980, encodeId=42c41429802b, content=文章很好,继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Mon Oct 10 10:41:18 CST 2016, time=2016-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1390358, encodeId=e88813903582b, content=<a href='/topic/show?id=22c6101695c9' target=_blank style='color:#2F92EE;'>#骨折风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101695, encryptionId=22c6101695c9, topicName=骨折风险)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKnILSXam1GxPwj04ylEzibYLFA2eGl5Ev02klt80JA0xejMPqrn0mYHNNnLEgyqYTPbicXpY3tn6SA/132, createdBy=38fd2500059, createdName=新生儿张玉军, createdTime=Sun Oct 09 05:57:00 CST 2016, time=2016-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571005, encodeId=ffe415e1005ff, content=<a href='/topic/show?id=f42823e48d7' target=_blank style='color:#2F92EE;'>#乳腺癌患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23748, encryptionId=f42823e48d7, topicName=乳腺癌患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=37bc15724202, createdName=hanhaisha2013, createdTime=Sun Oct 09 05:57:00 CST 2016, time=2016-10-09, status=1, ipAttribution=)]
    2017-05-22 laymankey

    感谢分享一下!

    0

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    2016-10-11 1e10c84am36(暂无匿称)

    好文章,受益

    0

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    2016-10-10 1e10c84am36(暂无匿称)

    文章很好,继续关注

    0

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    2016-10-10 1e10c84am36(暂无匿称)

    文章很好,继续关注

    0

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