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Eur Respir J:生命早期暴露于空气污染与儿童哮喘、过敏性鼻炎和湿疹的发生率

2019-12-08 xing.T MedSci原创

由此可见,暴露于氧化性空气污染物(O3和NO2)而不是PM2.5与儿童患哮喘和湿疹的风险增加相关。这表明改善空气质量可能有助于预防儿童期和青春期的哮喘和其他过敏性疾病。

越来越多的证据表明,空气污染可能会导致儿童哮喘和其他过敏性疾病的进展。近日,呼吸疾病领域权威杂志Eur Respir J上发表了一篇研究文章,在多伦多儿童健康评估问卷(T-CHEQ)研究的随访研究中,研究人员评估了从出生到青春期的早期空气污染暴露与哮喘、变应性鼻炎和湿疹发生率之间的关联。

研究人员随访了1286名T-CHEQ参与者,从出生到结局发现、2016年3月31日或失访,平均随访17年。使用地面观测、化学/气象模型、遥感和土地利用回归(LUR)模型,根据出生时的邮政编码以及1999年1月1日至2012年12月31日期间的NO2、O3和PM2.5浓度将参与者分组。研究结果包括医师诊断出的哮喘、过敏性鼻炎和湿疹的发生率。研究人员使用Cox比例风险回归模型估算每个四分位数的暴露和结局范围的风险比(HR),并调整潜在的混杂因素。

出生时总氧化剂(O3和NO2)暴露,对应哮喘的HRs为1.17(95%CI为1.05-1.31),湿疹为1.07(95%CI为0.99-1.15)。未发现PM2.5暴露哮喘和湿疹的风险显著增加。

由此可见,暴露于氧化性空气污染物(O3和NO2)而不是PM2.5与儿童患哮喘和湿疹的风险增加相关。这表明改善空气质量可能有助于预防儿童期和青春期的哮喘和其他过敏性疾病。 

原始出处:

Teresa To, et al.Early Life Exposure to Air Pollution and Incidence of Childhood Asthma, Allergic Rhinitis and Eczema.Eur Respir J.2019.https://erj.ersjournals.com/content/early/2019/11/13/13993003.00913-2019

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