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JACC:丙磺舒在治疗高龄痛风患者中心血管发生风险更小

2018-02-27 MedSci MedSci原创

痛风患者发生心血管疾病的风险大大增高。本研究的目的旨在比较评估痛风患者接受的两者不同药物治疗(丙磺舒和别嘌呤醇)在心血管方面的安全性。本研究纳入了2008年至2013年年龄≥65岁服用丙磺舒或别嘌呤醇治疗的痛风患者,主要终点事件是心梗和卒中的复合住院治疗,次要终点事件是心梗、卒中、冠脉血运重建、心衰和死亡。最终,共纳入分析了9722名接受丙磺舒治疗的患者,29166名接受别嘌呤醇治疗的患者,平均年

痛风患者发生心血管疾病的风险大大增高。本研究的目的旨在比较评估痛风患者接受的两者不同药物治疗(丙磺舒和别嘌呤醇)在心血管方面的安全性。

本研究纳入了2008年至2013年年龄≥65岁服用丙磺舒或别嘌呤醇治疗的痛风患者,主要终点事件是心梗和卒中的复合住院治疗,次要终点事件是心梗、卒中、冠脉血运重建、心衰和死亡。最终,共纳入分析了9722名接受丙磺舒治疗的患者,29166名接受别嘌呤醇治疗的患者,平均年龄是76 ± 7岁,男性占54%。主要终点事件的发生率每100人年在丙磺舒治疗组中为2.36,在别嘌呤醇治疗组中是2.83,危险比(HR)是0.8(95% Cl: 0.69-0.93)。此外,与别嘌呤醇治疗组相比,丙磺舒可以降低心梗、卒中、心衰和死亡率。

研究结果显示,在高龄痛风患者的药物治疗中,丙磺舒在心血管安全性方面要更佳。

原始出处:

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    2018-08-07 hbwxf
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    2018-03-07 owlhealth

    不错.学习了

    0

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    2018-03-01 xlysu

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