Baidu
map

转化医学

订阅

MedSci主页 / 所有栏目 / 转化医学

两家基因编辑公司强烈反击批评CRISPR导致突变的文章，称应将其撤稿

2017-06-11 MedSci MedSci原创

基因编辑CRISPR
关注

上周，《自然方法》杂志发表了一篇对CRISPR技术的批评文章，声称基因编辑工具CRISPR已经在小鼠基因组中引发了“意想不到的突变”。该文章的发表，导致两家基因编辑公司股票的暴跌：Intellia Therapeutics和Editas Medicine。近日，两家公司对该文章表示强烈不满，认为其结论完全错误，甚至就不应该公布。 Intellia公司的首席执行官呼吁将该文章撤稿，并将其从科学

上周，《自然方法》杂志发表了一篇对CRISPR技术的批评文章，声称基因编辑工具CRISPR已经在小鼠基因组中引发了“意想不到的突变”（详细见：Nat method：CRISPR基因编辑技术导致小鼠体内上百种非目标基因突变）。该文章的发表，导致两家基因编辑公司股票的暴跌：Intellia Therapeutics和Editas Medicine。近日，两家公司对该文章表示强烈不满，认为其结论完全错误，甚至就不应该公布。

Intellia公司的首席执行官呼吁将该文章撤稿，并将其从科学文献中删除。

他说：“这份出版物已经受到了媒体和公众的巨大关注，对我们造成了重大损失。鉴于该文章实验设计和结果讨论的问题，我认为《自然方法》杂志应该将其撤稿。”

《自然方法》出版方发言人则表示，他们已经收到了一些关于该文章的反馈，他们正在认真考虑，并与作者讨论相关问题。该文的作者并没有直接做出回应。

《体内CRISPR-Cas9编辑引发的不可预测基因突变》一文声称基因编辑工具在编辑小鼠基因过程中造成了广泛和不可预知的破坏，引入了数百种意外的基因突变。文章一经发表马上成为头条新闻，CRISPR概念股随后股价大跌。其中，Editas医药，Intellia Therapeutics和CRISPR治疗公司的股票市场总价值高达10亿多美元。


在Twitter等社交平台上，一些科学家很快指出了该文的部分基本错误，包括错误的基因识别、数量偏少的动物实验，最严重的是，该文将动物的正常遗传差异当作是CRISPR编辑带来的结果。Editas首席技术官与其它11位科学家联名写到，该文实验数据不能支持其结论。这些科学家中还包括来自哈佛大学教授。他们认为该文章“很有可能”被撤销，因为文章忽略了很多关键问题。

CRISPR技术被誉为“革命性的基因工程手段”，但有时它的作用会被夸大，包括声称这个技术可以会治愈所有遗传疾病，并解决世界的食物短缺问题。事实上，CRISPR的确可以剪切特定的DNA序列，从而修正或改变基因。虽然其功能强大，但如果基因组中其他位置有相同或相似的DNA序列，则可能导致更多DNA的随机改变。很多人都表示过对该技术潜在副作用的担心，其中甚至包括该技术的发明者们。

随意将CRISPR用于治疗可能是非常危险的。如果一个目标基因片段也同时处于重要的基因中，一个错误的基因切除可能是灾难性的，但许多科学家认为，找准基因片段可以消除大部分风险。

CRISPR的易用性意味着几乎任何实验室都有条件使用。中国已经开始在人类上进行实验，但这种操之过急的研究可能回让出错的可能性增大。 因此，Editas推迟了关于CRISPR用于治疗眼部疾病的研究。

然而，Intellia认为，该文章作者无视了CRISPR的很多研究成果，这些作者即不是CRISPR 的专家，也不是全基因组测序或者基因遗传学家，因此这种“意想不到的突变”的结论缺乏科学性。
与基因编辑相关的拓展阅读：

版权声明：
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料，版权均属于梅斯医学所有。非经授权，任何媒体、网站或个人不得转载，授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章，或“梅斯号”自媒体发布的文章，仅系出于传递更多信息之目的，本站仅负责审核内容合规，其内容不代表本站立场，本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系，我们将立即进行删除处理。
在此留言
评论区 (7)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=211094, encodeId=eac22110942f, content=是双面刃吧？, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4ee2039139, createdName=1361e94681m, createdTime=Thu Jun 15 12:19:49 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1276034, encodeId=013c12e6034cc, content=<a href='/topic/show?id=755d5211a0' target=_blank style='color:#2F92EE;'>#CRISPR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5211, encryptionId=755d5211a0, topicName=CRISPR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=583c133, createdName=yuandd, createdTime=Tue Jun 13 10:53:00 CST 2017, time=2017-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209823, encodeId=fc6c20982358, content=感谢分享！继续关注！, beContent=null, objectType=article, channel=null, level=null, likeNumber=145, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好！, createdTime=Mon Jun 12 12:23:40 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209769, encodeId=e057209e69c6, content=学习了，谢谢。。。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/icyLhIGqru6gIknBJqfuPhYUE4da7HxQiaMRRk8Ix0r6sfdeeibLPNib7H5IoNf4kYsecwUsmQC1eUMKsNb65twN7epPZaicdLRCu/0, createdBy=ba1a1999418, createdName=Norene, createdTime=Mon Jun 12 09:25:06 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209734, encodeId=68c0209e34d9, content=触犯到某些人的利益了, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/IibQxuGJg8Nh1KeNMs1nZJeeldYs9olQSmfLFMSmc8OR6afKD5WrY1ktGibkd2ccEG1hMLcfjsTroQ86Z9scbvicQ/132, createdBy=3d661927529, createdName=Mr.Li先生, createdTime=Mon Jun 12 08:06:58 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209596, encodeId=8ea92095960c, content=学习了谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=08bb2061153, createdName=189****7206, createdTime=Mon Jun 12 01:06:02 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209521, encodeId=cedd209521d1, content=动了商业的奶酪了, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sun Jun 11 21:00:45 CST 2017, time=2017-06-11, status=1, ipAttribution=)]
    2017-06-15 1361e94681m

    是双面刃吧？

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=211094, encodeId=eac22110942f, content=是双面刃吧？, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4ee2039139, createdName=1361e94681m, createdTime=Thu Jun 15 12:19:49 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1276034, encodeId=013c12e6034cc, content=<a href='/topic/show?id=755d5211a0' target=_blank style='color:#2F92EE;'>#CRISPR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5211, encryptionId=755d5211a0, topicName=CRISPR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=583c133, createdName=yuandd, createdTime=Tue Jun 13 10:53:00 CST 2017, time=2017-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209823, encodeId=fc6c20982358, content=感谢分享！继续关注！, beContent=null, objectType=article, channel=null, level=null, likeNumber=145, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好！, createdTime=Mon Jun 12 12:23:40 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209769, encodeId=e057209e69c6, content=学习了，谢谢。。。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/icyLhIGqru6gIknBJqfuPhYUE4da7HxQiaMRRk8Ix0r6sfdeeibLPNib7H5IoNf4kYsecwUsmQC1eUMKsNb65twN7epPZaicdLRCu/0, createdBy=ba1a1999418, createdName=Norene, createdTime=Mon Jun 12 09:25:06 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209734, encodeId=68c0209e34d9, content=触犯到某些人的利益了, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/IibQxuGJg8Nh1KeNMs1nZJeeldYs9olQSmfLFMSmc8OR6afKD5WrY1ktGibkd2ccEG1hMLcfjsTroQ86Z9scbvicQ/132, createdBy=3d661927529, createdName=Mr.Li先生, createdTime=Mon Jun 12 08:06:58 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209596, encodeId=8ea92095960c, content=学习了谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=08bb2061153, createdName=189****7206, createdTime=Mon Jun 12 01:06:02 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209521, encodeId=cedd209521d1, content=动了商业的奶酪了, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sun Jun 11 21:00:45 CST 2017, time=2017-06-11, status=1, ipAttribution=)]
    2017-06-13 yuandd

    #CRISPR#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=211094, encodeId=eac22110942f, content=是双面刃吧？, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4ee2039139, createdName=1361e94681m, createdTime=Thu Jun 15 12:19:49 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1276034, encodeId=013c12e6034cc, content=<a href='/topic/show?id=755d5211a0' target=_blank style='color:#2F92EE;'>#CRISPR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5211, encryptionId=755d5211a0, topicName=CRISPR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=583c133, createdName=yuandd, createdTime=Tue Jun 13 10:53:00 CST 2017, time=2017-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209823, encodeId=fc6c20982358, content=感谢分享！继续关注！, beContent=null, objectType=article, channel=null, level=null, likeNumber=145, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好！, createdTime=Mon Jun 12 12:23:40 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209769, encodeId=e057209e69c6, content=学习了，谢谢。。。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/icyLhIGqru6gIknBJqfuPhYUE4da7HxQiaMRRk8Ix0r6sfdeeibLPNib7H5IoNf4kYsecwUsmQC1eUMKsNb65twN7epPZaicdLRCu/0, createdBy=ba1a1999418, createdName=Norene, createdTime=Mon Jun 12 09:25:06 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209734, encodeId=68c0209e34d9, content=触犯到某些人的利益了, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/IibQxuGJg8Nh1KeNMs1nZJeeldYs9olQSmfLFMSmc8OR6afKD5WrY1ktGibkd2ccEG1hMLcfjsTroQ86Z9scbvicQ/132, createdBy=3d661927529, createdName=Mr.Li先生, createdTime=Mon Jun 12 08:06:58 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209596, encodeId=8ea92095960c, content=学习了谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=08bb2061153, createdName=189****7206, createdTime=Mon Jun 12 01:06:02 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209521, encodeId=cedd209521d1, content=动了商业的奶酪了, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sun Jun 11 21:00:45 CST 2017, time=2017-06-11, status=1, ipAttribution=)]
    2017-06-12 明天会更好！

    感谢分享！继续关注！

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=211094, encodeId=eac22110942f, content=是双面刃吧？, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4ee2039139, createdName=1361e94681m, createdTime=Thu Jun 15 12:19:49 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1276034, encodeId=013c12e6034cc, content=<a href='/topic/show?id=755d5211a0' target=_blank style='color:#2F92EE;'>#CRISPR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5211, encryptionId=755d5211a0, topicName=CRISPR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=583c133, createdName=yuandd, createdTime=Tue Jun 13 10:53:00 CST 2017, time=2017-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209823, encodeId=fc6c20982358, content=感谢分享！继续关注！, beContent=null, objectType=article, channel=null, level=null, likeNumber=145, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好！, createdTime=Mon Jun 12 12:23:40 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209769, encodeId=e057209e69c6, content=学习了，谢谢。。。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/icyLhIGqru6gIknBJqfuPhYUE4da7HxQiaMRRk8Ix0r6sfdeeibLPNib7H5IoNf4kYsecwUsmQC1eUMKsNb65twN7epPZaicdLRCu/0, createdBy=ba1a1999418, createdName=Norene, createdTime=Mon Jun 12 09:25:06 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209734, encodeId=68c0209e34d9, content=触犯到某些人的利益了, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/IibQxuGJg8Nh1KeNMs1nZJeeldYs9olQSmfLFMSmc8OR6afKD5WrY1ktGibkd2ccEG1hMLcfjsTroQ86Z9scbvicQ/132, createdBy=3d661927529, createdName=Mr.Li先生, createdTime=Mon Jun 12 08:06:58 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209596, encodeId=8ea92095960c, content=学习了谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=08bb2061153, createdName=189****7206, createdTime=Mon Jun 12 01:06:02 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209521, encodeId=cedd209521d1, content=动了商业的奶酪了, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sun Jun 11 21:00:45 CST 2017, time=2017-06-11, status=1, ipAttribution=)]
    2017-06-12 Norene

    学习了，谢谢。。。。。。

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=211094, encodeId=eac22110942f, content=是双面刃吧？, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4ee2039139, createdName=1361e94681m, createdTime=Thu Jun 15 12:19:49 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1276034, encodeId=013c12e6034cc, content=<a href='/topic/show?id=755d5211a0' target=_blank style='color:#2F92EE;'>#CRISPR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5211, encryptionId=755d5211a0, topicName=CRISPR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=583c133, createdName=yuandd, createdTime=Tue Jun 13 10:53:00 CST 2017, time=2017-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209823, encodeId=fc6c20982358, content=感谢分享！继续关注！, beContent=null, objectType=article, channel=null, level=null, likeNumber=145, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好！, createdTime=Mon Jun 12 12:23:40 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209769, encodeId=e057209e69c6, content=学习了，谢谢。。。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/icyLhIGqru6gIknBJqfuPhYUE4da7HxQiaMRRk8Ix0r6sfdeeibLPNib7H5IoNf4kYsecwUsmQC1eUMKsNb65twN7epPZaicdLRCu/0, createdBy=ba1a1999418, createdName=Norene, createdTime=Mon Jun 12 09:25:06 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209734, encodeId=68c0209e34d9, content=触犯到某些人的利益了, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/IibQxuGJg8Nh1KeNMs1nZJeeldYs9olQSmfLFMSmc8OR6afKD5WrY1ktGibkd2ccEG1hMLcfjsTroQ86Z9scbvicQ/132, createdBy=3d661927529, createdName=Mr.Li先生, createdTime=Mon Jun 12 08:06:58 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209596, encodeId=8ea92095960c, content=学习了谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=08bb2061153, createdName=189****7206, createdTime=Mon Jun 12 01:06:02 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209521, encodeId=cedd209521d1, content=动了商业的奶酪了, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sun Jun 11 21:00:45 CST 2017, time=2017-06-11, status=1, ipAttribution=)]
    2017-06-12 Mr.Li先生

    触犯到某些人的利益了

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=211094, encodeId=eac22110942f, content=是双面刃吧？, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4ee2039139, createdName=1361e94681m, createdTime=Thu Jun 15 12:19:49 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1276034, encodeId=013c12e6034cc, content=<a href='/topic/show?id=755d5211a0' target=_blank style='color:#2F92EE;'>#CRISPR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5211, encryptionId=755d5211a0, topicName=CRISPR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=583c133, createdName=yuandd, createdTime=Tue Jun 13 10:53:00 CST 2017, time=2017-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209823, encodeId=fc6c20982358, content=感谢分享！继续关注！, beContent=null, objectType=article, channel=null, level=null, likeNumber=145, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好！, createdTime=Mon Jun 12 12:23:40 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209769, encodeId=e057209e69c6, content=学习了，谢谢。。。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/icyLhIGqru6gIknBJqfuPhYUE4da7HxQiaMRRk8Ix0r6sfdeeibLPNib7H5IoNf4kYsecwUsmQC1eUMKsNb65twN7epPZaicdLRCu/0, createdBy=ba1a1999418, createdName=Norene, createdTime=Mon Jun 12 09:25:06 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209734, encodeId=68c0209e34d9, content=触犯到某些人的利益了, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/IibQxuGJg8Nh1KeNMs1nZJeeldYs9olQSmfLFMSmc8OR6afKD5WrY1ktGibkd2ccEG1hMLcfjsTroQ86Z9scbvicQ/132, createdBy=3d661927529, createdName=Mr.Li先生, createdTime=Mon Jun 12 08:06:58 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209596, encodeId=8ea92095960c, content=学习了谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=08bb2061153, createdName=189****7206, createdTime=Mon Jun 12 01:06:02 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209521, encodeId=cedd209521d1, content=动了商业的奶酪了, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sun Jun 11 21:00:45 CST 2017, time=2017-06-11, status=1, ipAttribution=)]
    2017-06-12 189****7206

    学习了谢谢分享。

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=211094, encodeId=eac22110942f, content=是双面刃吧？, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e4ee2039139, createdName=1361e94681m, createdTime=Thu Jun 15 12:19:49 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1276034, encodeId=013c12e6034cc, content=<a href='/topic/show?id=755d5211a0' target=_blank style='color:#2F92EE;'>#CRISPR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5211, encryptionId=755d5211a0, topicName=CRISPR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=583c133, createdName=yuandd, createdTime=Tue Jun 13 10:53:00 CST 2017, time=2017-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209823, encodeId=fc6c20982358, content=感谢分享！继续关注！, beContent=null, objectType=article, channel=null, level=null, likeNumber=145, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好！, createdTime=Mon Jun 12 12:23:40 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209769, encodeId=e057209e69c6, content=学习了，谢谢。。。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/icyLhIGqru6gIknBJqfuPhYUE4da7HxQiaMRRk8Ix0r6sfdeeibLPNib7H5IoNf4kYsecwUsmQC1eUMKsNb65twN7epPZaicdLRCu/0, createdBy=ba1a1999418, createdName=Norene, createdTime=Mon Jun 12 09:25:06 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209734, encodeId=68c0209e34d9, content=触犯到某些人的利益了, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/IibQxuGJg8Nh1KeNMs1nZJeeldYs9olQSmfLFMSmc8OR6afKD5WrY1ktGibkd2ccEG1hMLcfjsTroQ86Z9scbvicQ/132, createdBy=3d661927529, createdName=Mr.Li先生, createdTime=Mon Jun 12 08:06:58 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209596, encodeId=8ea92095960c, content=学习了谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=08bb2061153, createdName=189****7206, createdTime=Mon Jun 12 01:06:02 CST 2017, time=2017-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=209521, encodeId=cedd209521d1, content=动了商业的奶酪了, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sun Jun 11 21:00:45 CST 2017, time=2017-06-11, status=1, ipAttribution=)]
    2017-06-11 lovetcm

    动了商业的奶酪了

    0

相关资讯

首次在新的临床试验中进行体内人基因组编辑测试

科学家们之前已编辑过人基因组，但总是在体外的细胞中开展的。如今，作为一家生物技术公司，Sangamo 治疗公司（Sangamo Therapeutics，以下称 Sangamo）正在招募参与者参加几项临床试验：血友病 B、赫勒综合征（Hurler syndrome）或亨特综合征（Hunter syndrome）患者具有非功能性的酶，

Nature重磅：CRISPR再立功，华人科学家首次特异性靶向癌症融合基因

KillerT cells surround a cancer cell. 来源于 NIH2017年5月2日--昨天，匹兹堡大学医学院研究人员在Nature子刊《Nature Biotechnology》在线发表了一项新的研究结果，表明使用CRISPR基因组编辑技术可以有效地靶向致癌“融合基因”，减小肿瘤大小并改善了侵袭性肝癌和前列腺癌小鼠模型的生存期。Jian-HuaLuo博士Hig

李劲松教授：生殖干细胞介导的基因编辑



6月9日，由生物谷主办的2017（第四届）基因编辑与临床应用研讨会在沪隆重开幕。本次大会邀请到国内相关企业的专家和众多专家学者共同探讨基因编辑在临床应用中的重大突破，大会期间设有主题讨论环节，针对基因编辑技术实现规模化的临床应用面临的困难、基因编辑技术在肿瘤 · 2017-06-10

-->

范勇教授：CRISPR/Cas9基因编辑技术在人类胚胎水平治疗遗传病的应用

6月9日，由生物谷主办的第四届基因编辑与临床应用研讨会在沪隆重开幕。本次大会邀请到国内相关企业的专家和众多专家学者共同探讨基因编辑在临床应用中的重大突破，大会期间设有主题讨论环节，针对基因编辑技术实现规模化的临床应用面临的困难、基因编辑技术在肿瘤免疫治疗中的应用、未来会不会有更好的基因编辑技术出现, 特别是有自主知识产权的等问题进行探讨。基因编辑是近年来发展起来的可以对基因组完成精确修饰的一种技术

Advanced Biosystems：CRISPR编辑T细胞，微流控芯片助力免疫治疗

CRISPR-Cas9系统如暴风般横扫基因组学领域，正在给生物医学研究带来一场巨变。CRISPR/Cas9是最新出现的一种由gRNA导向的Cas9核酸酶对靶向基因进行编辑的技术，给揭示疾病发生机理以及靶向基因疗法治愈遗传疾病带来了希望。基于CRISPR的T细胞编辑为免疫靶向癌症、艾滋病以及先天性免疫缺陷等方向提供了新的治疗方案，然而高效的编辑和改造T细胞一直以来是该领域一个巨大挑战。近期，美国康奈

Nat method：CRISPR基因编辑技术导致小鼠体内上百种非目标基因突变

众所周知，CRISPR-Cas9 基因编辑技术凭借其快速和高精确度的特点，被科学家视为了解基因在疾病中作用的重要途径。与此同时，基因编辑技术由于可以删除或修复有缺陷的基因，所以它也为基因治疗带来了新的希望。世界上首例将 CRISPR 应用于人体的治疗案例

Baidu
map
Baidu
map
Baidu
map
Baidu
map