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BMC Nephrol:研究发现牙周炎似乎并不会增加肾衰患者的死亡率

2017-06-18 MedSci MedSci原创

已知牙周炎与慢性病患者的心血管死亡相关。然而,目前尚不清楚牙周炎是否可预测肾衰竭患者的生存。 ORAL-D是一种匹配分析,纳入了3338名终末期肾脏疾病接受血液透析的患者,来自欧洲和南美洲,以探讨长期血液透析的患者中牙周炎与全因死亡率和心血管死亡率之间的关联。使用世界卫生组织牙周指数评估中重度牙周炎患者倾向评分,按照1:1进行匹配。 结果,在3338名成人参与者中,基线时期1355名(

已知牙周炎与慢性病患者的心血管死亡相关。然而,目前尚不清楚牙周炎是否可预测肾衰竭患者的生存。

ORAL-D是一种匹配分析,纳入了3338名终末期肾脏疾病接受血液透析的患者,来自欧洲和南美洲,以探讨长期血液透析的患者中牙周炎与全因死亡率和心血管死亡率之间的关联。使用世界卫生组织牙周指数评估中重度牙周炎患者倾向评分,按照1:1进行匹配。

结果,在3338名成人参与者中,基线时期1355名(40.6%)患有中度至重度牙周炎。采用倾向评分法产生一个牙周炎与牙周健康或轻度牙周病,中度至重度牙周炎与全因死亡风险降低(9.1 VS 13每100人年,风险比0.74,95%置信区间0.61至0.90)和心血管疾病的死亡率降低(4.3 VS 6.9每100人年,危险比为0.67,0.51,0.88)相关。当患者具有12个或更多天然牙的时候,以及考虑心血管死亡的其他原因时,这些联系没有发生实质性变化。

总而言之,该研究发现牙周炎似乎并没有增加成人肾衰患者早期死亡的风险。

原始出处:

Marinella Ruospo, Suetonia C Palmer, et al., Periodontitis and early mortality among adults treated with hemodialysis: a multinational propensity-matched cohort study. BMC Nephrol. 2017; 18: 166.Published online 2017 May 22. doi:  10.1186/s12882-017-0574-x.

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    2017-06-18 xiaotaiyang1

    看看了解一下了,谢谢哦

    0

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    2017-06-18 lovetcm

    这个研究的bias非常大,仅仅是简单的匹配很难解决实际问题

    0

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    2017-06-18 清风拂面

    谢谢分享,学习了

    0

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    2017-06-18 1ddf0692m34(暂无匿称)

    病从口入

    0

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    2017-06-18 flysky120

    学习一下知识了

    0

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