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BJU Int:根治性膀胱切除术(RC)患者住院时间太短与再入院和出院后并发症的风险增加有关?

2017-10-30 fengxiangxin MedSci原创

本研究的目的是评估根治性膀胱切除术(RC)后早期出院的患者是否与再入院和出院后并发症的风险增加有关。

本研究的目的是评估根治性膀胱切除术(RC)后早期出院的患者是否与再入院和出院后并发症的风险增加有关。

研究者查询了国家手术质量改善计划(NSQIP)数据库,确定了从2012年至2015年接受择期RC的患者。他们将患者分为两组:早期出院组(住院时间(LOS)为4-5天)和常规出院组(LOS为6-9天)。通过使用多变量逻辑回归来评估早期出院对30天内再次入院和出院后并发症发生率的影响。最后进行灵敏度分析和亚组分析,以验证主要分析的可信度。

研究共纳入了3311例患者。未经调整的结果比较显示:早期出院和常规出院组之间的再入院率(21.6%vs 23.0%)或出院后并发症发生率(17.7%vs 19.6%)无统计学差异。多因素Logistic回归分析显示:早期出院与再入院比例增高(OR = 1.00,95%CI = 0.82-1.22,P = 1.000)或出院后并发症增多(OR = 0.95,95%CI = 0.77-1.17, P = 0.616)无关。两步敏感性分析(不包括因出院前发生不良事件,LOS为8-9天的患者)验证了主要分析的可信性。除85岁以上的亚组以外,其余亚组分析结果均显示了相似结果。

因此,研究者得出结论:RC后的早期出院与再入院或出院后并发症无关。在未来,需要具有明确的围手术期护理途径的前瞻性研究来确定能够使医院早日让患者出院,而不会影响出院后的结果的潜在组成部分。

原始出处:


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    2018-09-25 丁鹏鹏
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    2017-11-01 jeanqiuqiu
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    2017-10-30 1e0f8808m18(暂无匿称)

    学习了.谢谢分享.

    0

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Biomaterials:PLZ4-纳米卟啉可有效用于膀胱癌的治疗

膀胱癌的总体预后在过去30年并没有改善,因此,亟需找到膀胱癌新型诊断和治疗方法。本研究中,研究人员开发了一种多功能纳米卟啉平台,其中涂有膀胱癌特异性配体PLZ4。 单一程序中,PLZ4-纳米卟啉(PNP)可整合光动力学诊断、图像引导光动力学治疗、光热疗法和靶向化疗。PNPs是球形的,相对较小(直径约23nm),近红外光照射时优先发射荧光/热/活性氧。与游离DOX相比,PNPs负载多柔比星(DOX)

Oncotarget:膀胱癌侵袭的蛋白质组学分析:靶向EIF3D进行治疗干预。

此研究重点分析了膀胱癌发生侵袭的蛋白质组学变化,旨在更好地了解疾病病理生理学和对药物靶标的鉴定。研究者通过高离析液相色谱联合串联质谱对非肌层浸润性膀胱癌(NMIBC,pTa期)和肌层浸润性膀胱癌(MIBC,阶pT2 +期)患者的组织标本进行了分析。

Indian J Urol:MicroRNA-21可作为预测非肌肉侵入性膀胱癌复发的分子标记

非肌肉侵入性膀胱癌(NMIBC)的高复发率到目前为止还是一个巨大的挑战。 microRNA-21(miR-21)的超表达在膀胱肿瘤组织和正常粘膜的比较已经有所报道,并且miR-21能以与恶性肿瘤相关的磷酸酶和张力蛋白同源体基因(PTEN)为靶标。最近,有研究人员测试了是否miR-21在膀胱粘膜中的水平可以预测肿瘤复发。在一个前瞻性的群体研究中,研究人员在经尿道膀胱肿瘤切除术中从BC病人中获取了肿瘤

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