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这也行?因样本污染而撤稿,作者重写一版再次发表

2020-12-16 王聪 “Bio生物世界”公众号

2019年10月3日,以色列希伯来大学的 Nissim Benvenisty 团队在干细胞领域顶级期刊 Cell Stem Cell 发表了题为:Cancer-Related Mutations Id

2019年10月3日,以色列希伯来大学的 Nissim Benvenisty 团队在干细胞领域顶级期刊 Cell Stem Cell 发表了题为:Cancer-Related Mutations Identified in Primed and Naive Human Pluripotent Stem Cells 的研究论文。

在这篇论文中,研究团队利用RNA-seq数据鉴定癌症相关基因中的点突变,论证了人类多能干细胞(hPSC)中与癌症相关的突变,发现幼稚态细胞(Naive Cell)比始发态细胞(Primed Cell)的突变率更高。

然而,2020年12月14日,剑桥大学 Guo Ge 等人在 Cell Stem Cell 发表题为:Cancer-Related Mutations Are Not Enriched in Naive Human Pluripotent Stem Cells 的文章,重新分析了上述论文中的RNA-seq数据,发现在幼稚态细胞(Naive Cell)中发现的许多的点突变,其实是样本受到严重污染导致的,在消除这些污染之后,幼稚态细胞(Naive Cell)与始发态细胞(Primed Cell)没有差异。

Guo Ge 等人的这一质疑得到了原论文作者团队的认可,作者团队撤回了这篇 Cell Stem Cell 论文,并为他们的错误致歉。

撤稿之后还没完,论文作者随即修正了上述错误数据,重新写成了题为:Cancer-Related Mutations Identified in Primed Human Pluripotent Stem Cells 的论文,并依然发表在了 Cell Stem Cell 杂志上。

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    2021-07-24 zhzhxiang
  2. [GetPortalCommentsPageByObjectIdResponse(id=1669466, encodeId=21c21669466be, content=<a href='/topic/show?id=9d7b620395d' target=_blank style='color:#2F92EE;'>#样本#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62039, encryptionId=9d7b620395d, topicName=样本)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f33226554040, createdName=zhzhxiang, createdTime=Sat Jul 24 04:33:46 CST 2021, time=2021-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472708, encodeId=b47214e2708fb, content=<a href='/topic/show?id=ba4a6436107' target=_blank style='color:#2F92EE;'>#污染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64361, encryptionId=ba4a6436107, topicName=污染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dfe67217539, createdName=小刀医生, createdTime=Fri Dec 18 06:33:46 CST 2020, time=2020-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=908691, encodeId=52f090869134, content=了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Wed Dec 16 21:00:26 CST 2020, time=2020-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=908637, encodeId=c09e90863e32, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Dec 16 18:23:33 CST 2020, time=2020-12-16, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1669466, encodeId=21c21669466be, content=<a href='/topic/show?id=9d7b620395d' target=_blank style='color:#2F92EE;'>#样本#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62039, encryptionId=9d7b620395d, topicName=样本)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f33226554040, createdName=zhzhxiang, createdTime=Sat Jul 24 04:33:46 CST 2021, time=2021-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472708, encodeId=b47214e2708fb, content=<a href='/topic/show?id=ba4a6436107' target=_blank style='color:#2F92EE;'>#污染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64361, encryptionId=ba4a6436107, topicName=污染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dfe67217539, createdName=小刀医生, createdTime=Fri Dec 18 06:33:46 CST 2020, time=2020-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=908691, encodeId=52f090869134, content=了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Wed Dec 16 21:00:26 CST 2020, time=2020-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=908637, encodeId=c09e90863e32, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Dec 16 18:23:33 CST 2020, time=2020-12-16, status=1, ipAttribution=)]
    2020-12-16 wxl882001

    了解

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1669466, encodeId=21c21669466be, content=<a href='/topic/show?id=9d7b620395d' target=_blank style='color:#2F92EE;'>#样本#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62039, encryptionId=9d7b620395d, topicName=样本)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f33226554040, createdName=zhzhxiang, createdTime=Sat Jul 24 04:33:46 CST 2021, time=2021-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472708, encodeId=b47214e2708fb, content=<a href='/topic/show?id=ba4a6436107' target=_blank style='color:#2F92EE;'>#污染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64361, encryptionId=ba4a6436107, topicName=污染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dfe67217539, createdName=小刀医生, createdTime=Fri Dec 18 06:33:46 CST 2020, time=2020-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=908691, encodeId=52f090869134, content=了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Wed Dec 16 21:00:26 CST 2020, time=2020-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=908637, encodeId=c09e90863e32, content=好文章!, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Dec 16 18:23:33 CST 2020, time=2020-12-16, status=1, ipAttribution=)]
    2020-12-16 jyzxjiangqin

    好文章!

    0

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