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Nature:惊人发现,寨卡会影响男性生育力?

2016-11-02 佚名 生物通

导语:众所周知,寨卡病毒会导致新生儿小头畸形和一种严重的神经疾病。目前人们主要在研究寨卡病毒影响孕妇和胎儿的具体机制。然而Nature杂志发表的一项最新研究表明,寨卡病毒感染可能对男性也有很大危害,会严重干扰其生育能力。众所周知,寨卡病毒会导致新生儿小头畸形和一种严重的神经疾病。目前人们主要在研究寨卡病毒影响孕妇和胎儿的具体机制。然而Nature杂志发表的一项最新研究表明,寨卡病毒感染可能对男性也

导语:众所周知,寨卡病毒会导致新生儿小头畸形和一种严重的神经疾病。目前人们主要在研究寨卡病毒影响孕妇和胎儿的具体机制。然而Nature杂志发表的一项最新研究表明,寨卡病毒感染可能对男性也有很大危害,会严重干扰其生育能力。


众所周知,寨卡病毒会导致新生儿小头畸形和一种严重的神经疾病。目前人们主要在研究寨卡病毒影响孕妇和胎儿的具体机制。然而Nature杂志发表的一项最新研究表明,寨卡病毒感染可能对男性也有很大危害,会严重干扰其生育能力。

Kelle Moley教授及其同事指出,寨卡病毒能够靶标雄性生殖系统。感染寨卡三周之后,雄性小鼠会出现睾丸缩小、性激素水平降低、生育力减弱。这些小鼠令雌性小鼠受孕的机率也会大大降低。

此前有研究显示,寨卡病毒可以在男性精子中持续存在好几个月。研究人员将寨卡病毒注射到雄性小鼠体内,一周后这些病毒移动到睾丸并引发炎症。在两周后这些小鼠的睾丸显著缩小,内部结构崩溃,大量细胞死亡。三周后,小鼠睾丸缩小到了正常大小的十分之一,内部结构完全毁坏。研究人员对小鼠进行了持续六周的观察,在这段时间内小鼠睾丸并没有好转,即使血液中的病毒已经清除。

睾丸的内部结构依赖于Sertoli细胞,这些细胞负责维持血液与睾丸之间的屏障并滋养精子。研究人员发现,寨卡病毒能够感染和杀死Sertoli细胞,而Sertoli细胞不能再生。这项研究表明,受到寨卡感染之后小鼠的精子数和睾酮水平大幅下降。在感染六周后,小鼠的活动精子数下降十倍,睾酮水平也显著降低。与健康雄性小鼠相比,受感染小鼠使雌性小鼠受孕的机率要低四倍。“就我所知,只有这种病毒会造成这么严重的不育症状,”Moley说。“很少有微生物能跨越睾丸与血流之间屏障,直接感染睾丸。”

科学家们一直在与时间赛跑,希望尽快开发出安全有效的寨卡疫苗。六月份,他们终于取得了突破性进展。Nature杂志发表的一项研究表明,两种ZIKA疫苗能够为小鼠提供完全的保护,帮助小鼠对抗来自巴西的ZIKA菌株。研究人员指出,ZIKA疫苗用于人体很可能同样有效。

八月四日Science杂志发表的研究显示,候选寨卡疫苗已经成功通过了第二轮临床前研究。贝斯以色列女执事医疗中心BIDMC、华尔特•里德陆军研究院(WRAIR)以及圣保罗大学的研究人员证实,候选寨卡疫苗可以为猕猴提供完全的保护。这让研究者们对开发安全有效的寨卡疫苗非常乐观。

八月二十九日,Johns Hopkins大学、NIH和佛罗里达州立大学的研究人员通过药物筛选,找到了能够抵御寨卡病毒的两类化合物。这一重要研究成果发表在Nature Medicine杂志上,文章通讯作者是佛罗里达州立大学的唐恒立(Hengli Tang)教授,Johns Hopkins大学的宋红军(Hongjun Song)、明国丽(Guo-li Ming)教授,以及NIH的Wei Zheng。

原始出处:

Govero J1, Esakky P2, Scheaffer SM2, Fernandez E3, Drury A2, Platt DJ4, Gorman MJ3, Richner JM1, Caine EA1, Salazar V1, Moley KH2,5, Diamond MS1,3,4,6.Zika virus infection damages the testes in mice.Nature. 2016 Oct 31

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    2017-01-08 liye789132251
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    2016-11-02 1e137bdcm70(暂无匿称)

    如果试验成功,这将是个另大家欢欣鼓舞的发现

    0

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    2016-11-02 sillywu

    主要讲的是在卡病毒疫苗,而不是讲病毒危害

    0

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    2016-11-02 drmike

    這個研究是怎麼發現的~

    0

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    2016-11-02 flysky120

    谢谢,学习知识

    0

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